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Secondary amines

Organic compounds and functional groups that contain a basic nitrogen atom with a lone pair. Secondary amines have a nitrogen atom bonded to one hydrogen atom, and two carbon atoms or other functional groups.

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1

Medchemexpress LLC RP-1664 | 2980682-00-4 | 98.77% | 514.55 | 50 MG
SDP

RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. It demonstrates exquisite selectivity over related kinases, including AURKA/B and PLK1. It disrupts centriole biogenesis in cancer cells, leading to an accumulation of PLK4 and p21 protein. It shows increased sensitivity in TRIM37-high-expressing cells or tumors and exhibits anti-tumor activity in breast cancer and neuroblastoma research.

  • Selective and orally active PLK4 inhibitor.
  • IC50 of 3 nM for PLK4.
  • Exquisite selectivity over AURKA/B and PLK1.
  • Disrupts centriole biogenesis in cancer cells.
  • Leads to accumulation of PLK4 and p21 protein.
  • Increased sensitivity in TRIM37-high-expressing cells or tumors.
  • Exhibits anti-tumor activity in breast cancer and neuroblastoma research.

ENCOMPASS_PREFERRED
2

Medchemexpress LLC RP-1664 | 2980682-00-4 | 98.8% | 514.55 | 25 MG
SDP

RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. It demonstrates high selectivity over related kinases like AURKA/B and PLK1. This compound disrupts centriole biogenesis in cancer cells, leading to an accumulation of PLK4 and p21 protein. RP-1664 shows increased sensitivity in TRIM37-high-expressing cells or tumors and exhibits anti-tumor activity in breast cancer and neuroblastoma research.

  • Selective and orally active PLK4 inhibitor.
  • IC50 of 3 nM for PLK4.
  • Exhibits exquisite selectivity over related kinases such as AURKA/B and PLK1.
  • Disrupts centriole biogenesis in cancer cells.
  • Leads to accumulation of PLK4 and p21 protein.
  • Demonstrates increased sensitivity in TRIM37-high-expressing cells or tumors.
  • Exhibits anti-tumor activity in breast cancer and neuroblastoma research.
  • Appearance: Solid, White to off-white.

ENCOMPASS_PREFERRED
3

Medchemexpress LLC RP-1664 | 2980682-00-4 | 98.77% | 514.55 | 5 MG
SDP

RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. It demonstrates selectivity over related kinases like AURKA/B and PLK1. This compound disrupts centriole biogenesis in cancer cells, leading to an accumulation of PLK4 and p21 protein. RP-1664 shows increased sensitivity in TRIM37-high-expressing cells or tumors and exhibits anti-tumor activity in breast cancer and neuroblastoma research.

ENCOMPASS_PREFERRED
4

Medchemexpress LLC N-(3-aminopropyl)cyclohexylamine | 3312-60-5 | MFCD00003838 | 98.8% | 156.27 g/mol | C9H20N2 | 1 ML
SDP

N-(3-Aminopropyl)cyclohexylamine (CAS 3312-60-5) is a small-molecule spermidine synthase inhibitor supplied as a liquid or ready-to-use solution for biochemical and pharmacological research. It is used in assays probing polyamine metabolism and enzyme inhibition, and is offered in solution formats for direct use in experiments.

  • High purity (98.8%).
  • Molecular weight 156.27 g/mol.
  • Chemical formula C9H20N2.
  • Appearance: colorless to light yellow liquid.
  • Soluble in DMSO, water, and PBS; may require ultrasonic treatment.
  • Storage: 4°C protected from light; in solvent store at -80°C (6 months) or -20°C (1 month).

ENCOMPASS_PREFERRED