Alcohols and polyols
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- (462)
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- (1)
- (1)
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Filtered Search Results
Medchemexpress LLC Zenidolol hydrochloride | 72795-01-8 | 99.7% | 313.86 | 100 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Zenidolol hydrochloride (ICI-118551) is a highly selective β2 adrenergic receptor antagonist, demonstrating potent inhibition with Kis of 0.7, 49.5, and 611 nM for β2, β1, and β3 receptors, respectively. It is for research use only.
- Highly selective β2 adrenergic receptor antagonist
- Inhibits cAMP accumulation with an IC50 of 1.7 μM in IMCD cells
- Induces prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO (at 10 μM)
- Has significant effects on beat duration in failing human heart, reducing time-to-peak contraction and time-to-90% relaxation compared with basal contraction
- Negative inotropic effect is not cAMP-related
- Overexpression of β2AR in rabbit myocytes enhances negative inotropic effects
- Reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure when injected into the jugular vein of mice (at 0.2 mg/kg)
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Pociredir (hydrochloride) | 2490676-19-0 | 99.9% | 439.87 | 25 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Pociredir (FTX-6058) hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). It can induce HbF protein expression in cell and murine models and is used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia.
- Inhibits PRC2 via binding to EED
- Induces robust HbF protein expression in cell and murine models
- Used for research of select hemoglobinopathies
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Pholedrine (hydrochloride) | 877-86-1 | 99.6% | 25 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Pholedrine hydrochloride is the hydrochloride salt of pholedrine, an adrenergic cardiovascular agent used in research for its hypertensive and mydriatic effects. Supplied as a solid powder with high purity, it is intended for laboratory research applications.
- CAS number 877-86-1
- Chemical formula C10H16ClNO
- Molecular weight 201.69 g·mol⁻¹
- Purity 99.6%
- Appearance solid powder
- Storage 4°C sealed; in solution -80°C (6 months) or -20°C (1 month)
- Intended use research reagent for adrenergic and cardiovascular studies
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Pholedrine (hydrochloride) | 877-86-1 | 99.6% | 50 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Pholedrine hydrochloride is the hydrochloride salt of pholedrine, a sympathomimetic amine that acts on adrenergic receptors and is used in cardiovascular and receptor signaling research. It is supplied for laboratory research use with accompanying safety documentation and a certificate of analysis.
- Hydrochloride salt form for improved stability and solubility.
- High purity: 99.6% (LCMS, per COA).
- Molecular formula C10H16ClNO; molecular weight 201.69 g/mol.
- Used in adrenergic receptor and cardiovascular pharmacology studies.
- Available as a 50 MG research pack.
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Medchemexpress LLC Molindone hydrochlo | 50MG
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Molindone hydrochlo | 50MG
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Medchemexpress LLC DC-BPi-11 (hydrochloride) | 2758411-61-7 | 97.0% | C20H24ClN5O2S | 25 MG
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DC-BPi-11 hydrochloride is an inhibitor of bromodomain PHD finger transcription factor (BPTF) with an IC50 value of 698 nM. It shows remarkable inhibition against leukemia cell proliferation.
- Inhibitor of bromodomain PHD finger transcription factor (BPTF)
- Shows remarkable inhibition against leukemia cell proliferation
- Decreases downstream oncogene expression
- Dose-dependently decreases c-Myc protein level
- Induces cell apoptosis by arresting the cell cycle at G1 phase
- Minimal effects on normal cells
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Medchemexpress LLC DC-BPi-11 (hydrochloride) | 97.0% | C20H24ClN5O2S | 100 MG
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DC-BPi-11 hydrochloride is an inhibitor of bromodomain PHD finger transcription factor (BPTF), showing an IC50 value of 698 nM. It demonstrates significant inhibition against leukemia cell proliferation in human leukemia MV-4-11 cells with an EC50 value of 120 nM, while having minimal effects on normal cells, suggesting a favorable safety profile.
- Inhibits bromodomain PHD finger transcription factor (BPTF)
- Significantly inhibits leukemia cell proliferation
- Decreases downstream oncogene expression
- Dose-dependently decreases c-Myc protein level
- Minimal effects on normal cells
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Medchemexpress LLC SGK1-IN-3 hydrochloride | 96.65% | C23H21Cl3N6O3S | 50 MG
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SGK1-IN-3 hydrochloride (compound 3a) is a potent SGK1 inhibitor with an IC50 of <1 μM, and it has the potential for the research of osteoarthritis. This product is for research use only and not for sale to patients.
- Potent SGK1 inhibitor
- Potential for osteoarthritis research
- Purity of 96.65%
- Solid appearance with light yellow to yellow color
- Molecular weight of 567.88
- Soluble in DMSO at 125 mg/mL
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Medchemexpress LLC Pumosetrag Hydrochloride | 194093-42-0 | 99.8% | 339.84 | 50 MG
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Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
- Orally available 5-HT3 partial agonist.
- Developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
- Displays regional and species specificities.
- Activity is inhibited by ondansetron, confirming action on 5-HT(3) receptors.
- Delays liquid gastric emptying, stimulates fasting antroduodenal migrating motor complex activity, and accelerates small intestinal transit.
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Medchemexpress LLC BMT-090605 hydrochloride | 2231664-45-0 | 98.8% | 400.90 g/mol | C21H25ClN4O2 | 25 MG
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BMT-090605 hydrochloride is the hydrochloride salt of a potent kinase inhibitor selective for adaptor protein-2 associated kinase 1 (AAK1). It is supplied for preclinical research use, including studies of neuropathic pain, and shows activity versus related kinases in addition to AAK1.
- Potent AAK1 inhibitor (IC50 0.6 nM).
- Activity against BIKE and GAK (IC50 45 nM and 60 nM).
- High purity (98.8%).
- Molecular weight 400.90 g/mol; formula C21H25ClN4O2.
- Available as a solid in multiple sizes, including 25 mg.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or clinical use.
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Medchemexpress LLC SRI-37330 hydrochloride | 2322245-49-6 | 99.7% | C16H20ClF3N4O2S | 1 ML
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SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. It reduces hepatic glucose production, reverses hepatic steatosis, and inhibits glucagon secretion and function, making it a promising compound for type 2 diabetes research.
- Inhibits thioredoxin-interacting protein (TXNIP)
- Reduces hepatic glucose production
- Reverses hepatic steatosis
- Potential for type 2 diabetes research
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Medchemexpress LLC VU0357017 hydrochloride | 1135242-13-5 | 98.6% | 369.89 | 50 MG
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VU0357017 hydrochloride is a potent, selective, and brain-penetrant allosteric agonist of the M1 muscarinic acetylcholine receptor, exhibiting an EC50 of 477 nM. This compound demonstrates high selectivity for M1, showing no activity at M2-M5 receptors at concentrations up to 30 μM. It is being investigated for its potential use in the research of Alzheimer's disease and schizophrenia.
- Potent and selective allosteric agonist of M1 muscarinic acetylcholine receptor.
- Brain-penetrant.
- Highly selective for M1, with no activity at M2-M5 receptors at tested concentrations.
- Induces calcium release and ERK phosphorylation in CHO cells.
- Reverses scopolamine-induced cognitive deficits in animal models.
- Potential for research in Alzheimer's disease and schizophrenia.
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Medchemexpress LLC CCG258208 hydrochloride | 98.1% | 488.94 | 25 MG
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CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective inhibitor of GRK2 (G protein-coupled receptor kinase 2) with an IC50 of 30 nM. It demonstrates significant selectivity, being 230-fold more selective over GRK5 (IC50=7.09 μM) and over 2500-fold more selective over GRK1 (IC50=87.3 μM), PKA, and ROCK1. This compound is utilized in heart failure research.
- Potent and selective GRK2 inhibitor (IC50=30 nM).
- High selectivity over GRK5 (230-fold).
- Even higher selectivity over GRK1, PKA, and ROCK1 (more than 2500-fold).
- Applicable in heart failure research.
- Shows significant improvement in βAR-stimulated contractility in mouse cardiomyocytes at concentrations as low as 0.1 μM.
- Exhibits a superior half-life *in vivo*.
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Medchemexpress LLC Enerisant hydrochloride | 1152749-07-9 | 95.0% | 10 MG
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Enerisant hydrochloride is the hydrochloride salt of a potent, selective histamine H3 receptor antagonist/inverse agonist supplied as a research reagent for preclinical and in vitro studies. It is provided as a solid for laboratory use and is not intended for human or veterinary applications.
- Potent histamine H3 receptor antagonist/inverse agonist.
- Hydrochloride salt form for improved stability and solubility.
- CAS number 1152749-07-9 and molecular formula C22H31ClN4O3.
- Molecular weight 434.96 g·mol-1.
- Typical purity 95.0%.
- Packaged as a 10 mg solid; store frozen per supplier guidance.
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Medchemexpress LLC Ap-III-a4 hydrochloride | 2070014-95-6 | 99.9% | 631.18 g/mol | C31H44ClFN8O3 | 10 MG
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AP-III-a4 hydrochloride is a small-molecule, nonsubstrate analogue inhibitor of enolase supplied as the hydrochloride salt for research use. It is reported to bind and inhibit enolase (IC50 0.576 μM) and has been used in studies of cancer cell viability, migration, invasion, apoptosis, and glucose metabolism.
- Nonsubstrate analogue enolase inhibitor (IC50 0.576 μM).
- Used in cancer and diabetes research, including HCT116 cell assays.
- Shown to inhibit cell migration and invasion and to induce apoptosis.
- Increases glucose uptake and inhibits PEPCK expression in cell studies.
- Supplied as a hydrochloride solid suitable for laboratory assays, commonly available in small quantities such as 10 MG.
- Analytical documentation typically available (HPLC, LCMS, certificate of analysis).
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