Organic disulfides
Medchemexpress LLC Zelebrudomide (NX-2127) | 2416131-46-7 | C39H45N9O5 | 100 MG
Zelebrudomide (NX-2127) is an orally active PROTAC degrader that targets Bruton's Tyrosine Kinase (BTK). It inhibits the proliferation of BTKC481S mutant TMD8 cells more effectively than Ibrutinib. Zelebrudomide also catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with respective values of 25 nM and 54 nM. Additionally, it stimulates T cell activation and increases IL-2 production in primary human T Cells.
- Orally active PROTAC degrader targets Bruton's Tyrosine Kinase (BTK).
- Inhibits proliferation of BTKC481S mutant TMD8 cells more effectively than Ibrutinib.
- Catalyzes degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with respective values of 25 nM and 54 nM.
- Stimulates T cell activation and increases IL-2 production in primary human T Cells.
- Demonstrates potent degradation of BTK in vivo.
- Results in superior tumor growth inhibition in both WT TMD8 and C481S mutant xenograft models in mice.
Medchemexpress LLC NX-2127 | 2416131-46-7 | C39H45N9O5 | 200 MG
Zelebrudomide (NX-2127) is an orally active PROTAC degrader targeting Bruton's Tyrosine Kinase (Btk). It effectively inhibits proliferation of BTKC481S mutant TMD8 cells and catalyzes degradation of Ikaros (IKZF1) and Aiolos (IKZF3). It also stimulates T cell activation and increases IL-2 production.
- Orally active PROTAC degrader.
- Targets Bruton's tyrosine kinase (Btk).
- Inhibits BTKC481S mutant TMD8 cell proliferation (EC50 <30 nM).
- Catalyzes Ikaros (IKZF1) and Aiolos (IKZF3) degradation.
- Stimulates T cell activation; increases IL-2 production.
- Potent BTK degradation in cynomolgus monkeys in vivo.
- Superior tumor growth inhibition in WT TMD8 and C481S mutant xenograft models.
- Appearance: solid, light yellow to yellow.
- Purity: 99.72%.
Medchemexpress LLC Hydroxyethyl disulfide | 1892-29-1 | MFCD00002906 | 98.8% | 154.25 g/mol | C4H10O2S2 | 25 G
Hydroxyethyl disulfide is a small-molecule disulfide reagent used in biochemical research and enzymology. It has been reported to block the inhibitory effect of showdomycin on methotrexate-resistant thymidylate synthase. Prior to use, consult the safety data sheet and certificate of analysis for handling and quality information.
- High purity suitable for research use.
- Single CAS-registered chemical for unambiguous identification.
- Simple molecular composition with formula C4H10O2S2.
- Available in multiple sizes, including a 25 g package.
- Safety and quality documentation (SDS, COA, datasheet) available.
Medchemexpress LLC N N-Dicyclohexyl-2-b 10g
N N-Dicyclohexyl-2-benzothiazolesulfenamide is a compound with reproductive and developmental toxicity that can affect body weight gain reproductive organ weight and multiple reproductive and developmental indicators in rats
eMolecules Mal-PEG11-Lipoamide | 100MG | Purity: 95%
Broadpharm | Mal-PEG11-Lipoamide | 100MG | MFCD24673693
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Medchemexpress LLC Diphenyl disulfide | 882-33-7 | MFCD00003065 | 100.0% | 218.35 g/mol | C12H10S2 | 1mL
Diphenyl disulfide is an endogenous metabolite Diphenyl disulfide is a pharmaceutical intermediate Diphenyl disulfide can be coupled with aryl iodide to synthesize asymmetric aryl sulfide[1][2]
![eMolecules Broadpharm / DSPE-SPDP / 50mg / 649282048 / BP-26161 / / 144735-79-5 / [null] / 945.350 / C49H89N2O9PS2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502480332.JPG-250.jpg)
eMolecules Broadpharm / DSPE-SPDP / 50mg / 649282048 / BP-26161 / / 144735-79-5 / [null] / 945.350 / C49H89N2O9PS2
Broadpharm / DSPE-SPDP / 50mg / 649282048 / BP-26161 / / 144735-79-5 / [null] / 945.350 / C49H89N2O9PS2
Medchemexpress LLC Dipropyl disulfide | 629-19-6 | MFCD00009378 | 99.3% | 150.31 g/mol | C6H14S2 | 5 G
Dipropyl disulfide (CAS 629-19-6) is an organic dialkyl disulfide used as a research reagent and analytical standard. It is metabolized to dipropyl thiosulfinate by microsomal enzymes and is used in metabolism and analytical studies. Certificate of analysis and safety data sheet are provided for quality and safety documentation.
- Chemical formula C6H14S2 and molecular weight 150.31 g/mol.
- High purity of 99.3%.
- Available in multiple pack sizes, including 5 g.
- COA and SDS documentation available for each lot.
- Suitable for research and analytical applications.
Medchemexpress LLC HY-N0492 500mg Medchemexpress, α-Lipoic Acid CAS:1077-28-7 Purity:>98%
Medchemexpress, HY-N0492 500mg α-Lipoic Acid CAS:1077-28-7 α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Chemscene ChemScene | 2,2′-Dipyridyl disulfide | 25G | CS-W008788 | 0.98 | 82979| MFCD00006287 | 220.32
ChemScene | 2,2′-Dipyridyl disulfide | 25G | CS-W008788 | 0.98 | 82979| MFCD00006287 | 220.32
Chemscene ChemScene | SPDP | 250MG | CS-5649 | 0.98 | 68181-17-9| MFCD00009636 | 312.37
ChemScene | SPDP | 250MG | CS-5649 | 0.98 | 68181-17-9| MFCD00009636 | 312.37
Medchemexpress LLC HY-D0844 100mg Medchemexpress, Glutathione oxidized CAS:27025-41-8 Purity:>98%
Medchemexpress, HY-D0844 100mg Glutathione oxidized CAS:27025-41-8 Glutathione oxidized is produced by the oxidation of glutathione which is a major intracellular antioxidant and detoxifying agent. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
