Sulfonyls
Selleck Chemical LLC Sulfathiazole S3116-50mg
Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug
Medchemexpress LLC Benzenesulfonamide, 4-amino-N-2-thiazolyl- | 72-14-0 | 99.7% | 500 MG
Sulfathiazole is an orally active, organosulfur compound functioning as a short-acting sulfonamide antibiotic and an endocrine disruptor. It targets the steroidogenic pathway, enhancing CYP19 activity in human adrenal cells (H295R) and upregulating mRNA expression of CYP17, CYP19, and 3β-HSD. It also increases 17-estradiol (E2) production and exhibits endocrine-disrupting effects on aquatic organisms like the Japanese medaka fish. This product is a white to off-white solid with a molecular formula of C9H9N3O2S2 and a molecular weight of 255.32. It is intended for research use only.
- Purity of 99.71%
- Orally active sulfonamide antibiotic
- Targets steroidogenic pathway by enhancing CYP19 activity
- Appears as a white to off-white solid
- Recommended for long-term storage in powder form at -20°C for 3 years or 4°C for 2 years
- Recommended for storage in solution at -80°C for 6 months or -20°C for 1 month
eMolecules 2447-57-6 | 4-Amino-N-(5,6-dimethoxypyrimidin-4-yl)benzene-1-sulfonamide | Combi-Blocks | MFCD00792890 | 310.330 | C12H14N4O4S | 98.000 | COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC | 5g | 117536439
4-Amino-N-(5,6-dimethoxypyrimidin-4-yl)benzene-1-sulfonamide | Combi-Blocks | 2447-57-6 | MFCD00792890 | 310.330 | C12H14N4O4S | 98.000 | COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC | 5g | 117536439
Medchemexpress LLC Sulfadiazine | 68-35-9 | 99.9% | 1 G
Sulfadiazine is a sulfonamide antibiotic with antimalarial activity, primarily used for toxoplasmosis research. With a molecular formula of C10H10N4O2S and a molecular weight of 250.28, this compound targets bacterial and parasitic organisms, functioning within the anti-infection pathway. It is available in solid form.
- Purity is 99.89%.
- Powder is stable for 3 years at -20°C and 2 years at 4°C.
- In solvent, stable for 2 years at -80°C and 1 year at -20°C.
- In vitro solubility: soluble in DMSO (≥ 50 mg/mL) but insoluble in H₂O.
- In vivo solubility options include 10% DMSO with various diluents.
- IC₅₀ and target information for Toxoplasma is available.
Medchemexpress LLC Sulfathiazole | 72-14-0 | MFCD00005319 | 99.7% | 1 G
Sulfathiazole is an orally active endocrine disruptor that targets the steroidogenic pathway. It specifically enhances the activity of CYP19 in human adrenal cancer cells (H295R) and upregulates the mRNA expression of CYP17, CYP19, and 3β-HSD. It also increases the production of 17-estradiol (E2) and demonstrates endocrine disrupting effects on aquatic organisms like the Japanese medaka fish.
- Targets the steroidogenic pathway
- Enhances CYP19 activity in human adrenal cancer cells (H295R)
- Upregulates mRNA expression of CYP17, CYP19, and 3β-HSD
- Increases production of 17-estradiol (E2)
- Demonstrates endocrine disrupting effects on aquatic organisms
- Can inhibit copper corrosion in 0.1 M NaCl solution
- Increases plasma 17-estradiol concentrations in male Japanese medaka models
Selleck Chemical LLC 2-Aminobenzenesulfonamide S4998-25mg
2-Aminobenzenesulfonamide (Orthanilamide O-Aminobenzenesulfonamide O-Sulfanilamide Benzenesulfonamide) is an inhibitor of Carbonic Anhydrase IX (CAIX) / Carbonic Anhydrase 9 (CA9)
Apexbio Technology LLC Sulfathiazole 72-14-0 10mM (in 1mL DMSO)
Sulfathiazole (CAS 72-14-0) is a small-molecule inhibitor targeting dihydropteroate synthase (DHPS) It is designed to competitively inhibit bacterial folic acid synthesis thereby disrupting the folate pathway and impeding microbial growth Sulfathiazole exerts its biological activity primarily through inhibition of DHPS In in vitro studies sulfathiazole demonstrates bacteriostatic inhibition with IC50 values ranging from low to medium micromolar concentrations depending on specific bacterial strains and experimental conditions Based on these pharmacological properties sulfathiazole holds research potential in investigating antibacterial resistance metabolic pathways of pathogens and enzyme-substrate interactions in microbiological and biochemical research
Apexbio Technology LLC Sulfathiazole 72-14-0 10g
Sulfathiazole (CAS 72-14-0) is a small-molecule inhibitor targeting dihydropteroate synthase (DHPS) It is designed to competitively inhibit bacterial folic acid synthesis thereby disrupting the folate pathway and impeding microbial growth Sulfathiazole exerts its biological activity primarily through inhibition of DHPS In in vitro studies sulfathiazole demonstrates bacteriostatic inhibition with IC50 values ranging from low to medium micromolar concentrations depending on specific bacterial strains and experimental conditions Based on these pharmacological properties sulfathiazole holds research potential in investigating antibacterial resistance metabolic pathways of pathogens and enzyme-substrate interactions in microbiological and biochemical research
Medchemexpress LLC Sulfapyridine | 144-83-2 | MFCD00038036 | 99.9% | 1 G
Sulfapyridine is a sulfonamide antibiotic that is a major metabolite of Sulfasalazine. It acts as an antibiotic agent by inhibiting recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Beyond its antibacterial properties, Sulfapyridine also exhibits anti-inflammatory and anti-rheumatic activities.
- Inhibits IL-8, CXCL1, and MCP-1 production in synovial cells
- Active against Y. enterocolitica and Salmonella
- Significantly inhibits systemic allergic reactions in rats
- For research use only
Apexbio Technology LLC 2-Aminobenzenesulfonamide
2-Aminobenzenesulfonamide (CAS No 3306-62-5) is a research compound often utilized in biomedical studies due to its potential interactions with various biological pathways Originating from benzenesulfonamide derivatives it shows activity primarily in altering enzyme function and protein interactions In vitro its efficacy is observed within the nanomolar to low micromolar range making it valuable in examining cellular responses and potential therapeutic effects Common applications include drug screening and mechanistic studies using various cell models and sometimes extended to animal studies for further pharmacokinetic investigations Experimental concentrations typically depend on the specific research design and objectives allowing flexibility in exploratory research settings