Sulfoxides
Medchemexpress LLC YK-2168 | 2571068-74-9 | 98.1% | 315.80 | 25 MG
YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. It inhibits phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. This compound induces apoptosis in tumor cells, suppresses the expression of CDK9-regulated genes, and inhibits tumor growth in CDX mice models. It is suitable for cancer research, including leukemia.
- Potent and selective CDK9 inhibitor (IC50 = 5.9 nM)
- Inhibits phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain
- Induces apoptosis in tumor cells
- Suppresses expression of CDK9-regulated genes (e.g., MYC and Mcl1)
- Inhibits tumor growth in CDX mice models
- High selectivity over CDK1 and CDK2
- Does not inhibit hERG channel activity at concentrations up to 30 μM
- Demonstrates a good safety profile in animal models
Medchemexpress LLC Benzenepropanoic acid, 4-[[4-(2-chlorophenyl)-2-thiazolyl]methoxy]-2-methyl- | 1050506-87-0 | 97.1% | C20H18ClNO3S | 1 ML
GPR120 modulator 2 is a chemical compound with a molecular formula of C20H18ClNO3S and a molecular weight of 387.88. This compound is a white to off-white solid and has a purity of 97.11% as determined by HPLC, with its mass spectrometry consistent with its structure.
- Molecular formula: C20H18ClNO3S
- Molecular weight: 387.88
- Appearance: White to off-white solid
- Purity (HPLC): 97.11%
- Mass spectrometry consistent with structure
Medchemexpress LLC GPR120 modulator 1 | 1050506-75-6 | 98.06% | C19H16ClNO4S | 50 MG
GPR120 modulator 1 is a G protein-coupled receptor 120 (GPR120) modulator, extracted from patent US8394841B2, compound example F1. It is intended for research use only and can be used for the study of diseases associated with abnormal or deregulated GPR120, such as diabetes.
- G protein-coupled receptor 120 (GPR120) modulator
- Extracted from patent US8394841B2, compound example F1
- Useful for research of diseases associated with abnormal or deregulated GPR120, such as diabetes
- For research use only
Medchemexpress LLC GPR120 modulator 2 | 1050506-87-0 | 97.1% | 387.88 | C20H18ClNO3S | 10 MG
GPR120 modulator 2 is a small-molecule research compound that modulates the free fatty acid receptor GPR120 and is intended for in vitro pharmacology and metabolic signaling studies.
- Targets the free fatty acid receptor GPR120.
- Molecular formula C20H18ClNO3S and molecular weight 387.88.
- CAS number 1050506-87-0 for unambiguous identification.
- High purity (97.1%) suitable for research applications.
- Available in small pack sizes, including 10 mg.
- Storage: powder at -20°C for long-term stability, 4°C short term; in solvent store at -80°C.
Medchemexpress LLC GLP-1R modulator C16 | 875005-43-9 | 98.7% | C21H26ClFN2O3 | 100 MG
GLP-1R modulator C16 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site with an EC50 of 8.43 ± 3.82 μM. It has a molecular weight of 408.89, appears as a solid with a white to off-white color, and is for research use only.
- Enhances GLP-1 binding to GLP-1R
- Allosteric modulator
- Molecular weight of 408.89
- Appears as a solid
- White to off-white color
- For research use only
Medchemexpress LLC GLP-1R modulator L7-028 | 2648317-95-5 | MFCD34602898 | 99.5% | 392.49 | C24H28N2O3 | 5 MG
GLP-1R modulator L7-028 is a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R). It enhances GLP-1 binding at a transmembrane site (reported EC50 11.01 ± 2.73 μM) and is supplied for research use only as a solid with high analytical purity for in vitro studies of GLP-1R signaling.
- Enhances GLP-1 binding via a transmembrane allosteric site.
- Reported EC50 11.01 ± 2.73 μM for GLP-1R modulation.
- High analytical purity suitable for research (≈99.5%).
- Available in small pack sizes for laboratory use.
- Molecular formula C24H28N2O3 and molecular weight 392.49.
Medchemexpress LLC 3',4'-Tetramethylene-α-pyrrolidinobutiophenone hydrochloride | 2749504-65-0 | 99.9% | 307.86 | 5 MG
This product is a laboratory chemical, 3',4'-Tetramethylene-α-pyrrolidinobutiophenone hydrochloride, intended for research use only and suitable for the manufacture of substances. It should be handled by suitably qualified and experienced scientists in appropriately equipped and authorized facilities. The substance is stable under recommended storage conditions but is incompatible with strong acids/alkalis and strong oxidizing/reducing agents. It is not classified as a hazardous substance or mixture.
- Identified for laboratory use and substance manufacturing.
- Stable under recommended storage conditions.
- High purity of 99.9%.
- Molecular formula C18H26CINO.
- Powder storage: -20°C for 3 years, 4°C for 2 years.
- In solvent storage: -80°C for 6 months, -20°C for 1 month.
- Not a hazardous substance or mixture.
Medchemexpress LLC IL-17 modulator 3 | 2467731-88-8 | 99.5% | 579.73 | 1 MG
IL-17 modulator 3 is an IL-17 modulator, as described in US20200247785A1. It can be used for research related to inflammation, cancer, and autoimmune diseases. This compound is intended for research use only and is not sold to patients. It appears as a solid, with a color ranging from light yellow to yellow.
- Functions as an IL-17 modulator
- Useful for research related to inflammation, cancer, and autoimmune diseases
- Intended for research use only
- Appears as a solid
- Color ranges from light yellow to yellow
Medchemexpress LLC Elafibranor sulfoxide | 95.0% | 400.49 | 25 MG
Elafibranor (GFT505) sulfoxide is a sulfoxide metabolite of Elafibranor (HY-16737). Elafibranor is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively. Elafibranor can be used for the study of primary biliary cholangitis.
- Purity: 95.0%
- Molecular weight: 400.49
- Formula: C22H24O5S
- Appearance: Solid
- Color: Light yellow to yellow
- Solubility (in vitro): 100 mg/mL (DMSO)
- Storage (powder): -20°C 3 years, 4°C 2 years
- Storage (in solvent): -80°C 6 months, -20°C 1 month
- Research use only
Medchemexpress LLC 1-Butanesulfonic acid, sodium salt | 2386-54-1 | MFCD00007540 | 98.0% | 160.17 g/mol | C4H9NaO3S | 1 G
Sodium butane-1-sulfonate (sodium 1-butanesulfonate) is an anionic sulfonate salt supplied as a white to off-white solid. It is used primarily as an ion-pairing reagent or mobile-phase additive in chromatographic separations, for example to improve separation of arsenic and selenium species. Typical purity is 98.0% and it is available in small laboratory pack sizes.
- Anionic sulfonate suitable for ion-pairing in HPLC.
- Improves separation of arsenic and selenium species.
- White to off-white solid with stated purity of 98.0%.
- Molecular weight 160.17 g/mol; formula C4H9NaO3S.
- Supplied in small laboratory pack sizes for analytical use.
Medchemexpress LLC Sodium decane-1-sulfonate | 13419-61-9 | 244.33 | 25 G
Sodium decane-1-sulfonate is an anionic surfactant primarily used for the analysis of organic small molecule compounds. It is commonly employed in HPLC and ion-pair liquid chromatography applications.
- Used for analysis of organic small molecule compounds
- Utilized in HPLC applications
- Utilized in ion-pair liquid chromatography
- Appearance: solid
Cayman Chemical Sulindac Inhibitors
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg