Sulfoxides
Aobchem Allyl(3 5-dimethoxyphenyl)sulfane | 97% | C11H14O2S | 250mg
Allyl(3 5-dimethoxyphenyl)sulfane | 97% | C11H14O2S | 250mg
Medchemexpress LLC 2H-Indol-2-one, 1,3-dihydro-3-hydroxy-3-(2-oxo-2-phenylethyl)-1-(2-phenylethyl)- | 421578-93-0 | 99.81% | C24H21NO3 | 1 ML
GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM). This compound is for research use only.
- Allosteric modulator
- Enhances GLP-1 binding to GLP-1R
- Via a transmembrane site
Medchemexpress LLC Sirtuin modulator 2 | 667910-69-2 | 99.2% | 349.41 | 25 MG
Sirtuin modulator 2 (Compound 132) is a sirtuin modulator exhibiting an ED50 equal to or less than 50 μM. It is intended for research use only. This compound is characterized by its molecular weight of 349.41 and appears as a light yellow to yellow solid.
- Appears as a light yellow to yellow solid.
- Has an ED50 equal to or less than 50 μM.
- Intended for research applications.
Medchemexpress LLC CB2R/FAAH modulator-3 | 2876918-67-9 | C22H31NO2 | 50 MG
CB2R/FAAH modulator-3 (compound 27) is a dual-targeting modulator that acts as a CB2R agonist and FAAH inhibitor, with Ki values of 20.1 nM for CB2R and 67.6 nM for CB1R, and an IC50 value of 3.4 μM for FAAH. At 10 μM, it reduces the production of pro-inflammatory cytokines TNFα, IFN-γ, IL-1β, and IL6 in unstimulated monocytes and macrophages. This modulator can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.
- Molecular weight: 341.49
- Formula: C22H31NO2
- CAS no.: 2876918-67-9
- Appearance: Solid
- Color: White to off-white
- Purity: 99.71%
Medchemexpress LLC YK-2168 | 2571068-74-9 | 98.05% | 315.80 | 50 MG
YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. It inhibits the phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. YK-2168 induces apoptosis in tumor cells, suppresses the expression of CDK9-regulated genes such as MYC and Mcl1, and inhibits tumor growth in CDX mice models. This product can be used for cancer research, including leukemia.
- Potently inhibits purified CDK9 enzymatic activity
- Exhibits high selectivity over CDK1 and CDK2
- Inhibits proliferation of MV4-11 leukemia cells
- Induces dose-dependent inhibition of tumor growth in CDX mice models
- Suppresses CDK9-regulated gene expression
- Upregulates cleaved caspase 3, indicating induced apoptosis
- Maintains a good safety profile in vivo with no significant body weight changes
Medchemexpress LLC NR2F6 modulator-1 | 904449-84-9 | 99.46% | 419.45 | 1 ML
NR2F6 modulator-1 is a potent nuclear receptor subfamily 2, group F, member 6 (NR2F6) modulator. It is utilized for research concerning immune modulation and the modulation of cancer stem cell activity.
- Potent nuclear receptor subfamily 2, group F, member 6 (NR2F6) modulator
- Utilized for researching immune modulation
- Utilized for modulation of cancer stem cell activity
- Appears as a solid
- Color ranges from off-white to light yellow
- Soluble in DMSO at 125 mg/mL
Medchemexpress LLC Mrgprx2 modulator-1 (example 17) | 2781839-42-5 | 99.0% | 459.39 g/mol | C20H19F6N5O | 10 MG
MRGPRX2 modulator-1 (example 17) is a small-molecule modulator of the Mas-related G-protein coupled receptor X2 (MRGPRX2) supplied for preclinical research. It is intended for studies of inflammation, pain signaling, and autoimmune disorders and is characterized by a confirmed molecular formula, molecular weight, and high HPLC purity.
- Small-molecule modulator of MRGPRX2 suitable for preclinical research.
- High purity (99.03% by HPLC) for consistent bioactivity.
- Molecular formula: C20H19F6N5O; molecular weight: 459.39 g/mol.
- Assigned CAS number 2781839-42-5 for unambiguous identification.
- Provided as a powdered research reagent; handle per SDS instructions.
TARGETMOL CHEMICALS INC CB2R/FAAH MODULATOR-3 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CB2R/FAAH modulator-3 (compound 27) is a modulator targeting at CB2R and FAAH. CB2R/FAAH modulator-3 acts as a CB2R agonist and FAAH inhibitor the Ki values are 20.1 and 67.6 nM for CB2R and CB1R respectively and the IC50 value for FAAH is 3.4 uM. CB2R/FAAH modulator-3 has research value related to cancer deleterious inflammatory cascades occurring in neurodegenerative diseases and COVID-19 infection. purity: 99%
Sigma Aldrich Fine Chemicals Biosciences 1,2-Bis(phenylsulfinyl)ethane palladium(II) acetate | 858971-43-4 | MFCD09842752 | 250MG
1,2-Bis(phenylsulfinyl)ethane palladium(II) acetate | Mol Wt: 502.9 | 858971-43-4 | MFCD09842752 | 250MG
Cayman Chemical GlycerophosphoNPalmitoyl Etha
Precursor of PEA, an endogenous CB found in brain, liver, and other mammalian tissues; PEA has potent anti-inflammatory activity in vivo
Medchemexpress LLC CXCR7 modulator 2 | 2227426-37-9 | 98.71% | 522.68 | 1 ML
CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM. It is for research use only and not sold to patients. This modulator offers protection against cardiac injury.
- Potent CXCR7-binding affinity (Ki=13 nM).
- β-arrestin activity (EC50=11 nM).
- Improved selectivity in the GPCR panel.
- Improved therapeutic index in the hERG patch-clamp assay.
- Moderate to high in vitro turnover in NADPH-supplemented mouse-liver microsomes (MLM, 93 μL/min/mg) and hepatocytes (28 μL/min per million cells).
- Good aqueous solubility.
- Rapidly absorbed with a mean maximal plasma concentration (Cmax) of 682 ng/mL at 0.25 h (Tmax).
- Reduces cardiac fibrosis in an isoproterenol-induced cardiac injury model in mice.