Sulfoxides
AdipoGen GS-441524 Remdesivir Metabol
Chemical. CAS 1191237-69-0. Formula C12H13N5O4. MW 291.3. GS-441524 is the active prodrug of the broad-spectrum antiviral Remdesivir. GS-441524 is an adenosine nucleotide analog in viral RNA production. It is a nucleotide analog inhibitor of RNA-dependent RNA polymerases RdRps. The compound interferes with the action of viral RNA polymerase and evades proofreading by viral exoribonuclease ExoN, causing a decrease in viral RNA production RNA synthesis arrest, either by terminating RNA chains or causing mutations. It inhibits MERS-CoV or SARS-CoV-infected HAE cultures EC50=74nM and 69nM and murine hepatitis virus MHV EC50=30nM. In vivo, remdesivir 25 and 50 mg/kg reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection.
Medchemexpress LLC Elafibranor sulfoxide | 95.0% | 400.49 | C22H24O5S | 10 MG
Elafibranor sulfoxide is the sulfoxide metabolite of elafibranor supplied as a research-grade powder for in vitro and preclinical studies. It is intended for laboratory research use only and can be used to investigate PPAR-related pathways and metabolic disease models such as primary biliary cholangitis.
- Chemical formula C22H24O5S, molecular weight 400.49.
- Supplied as a powder; pack sizes include 10 MG.
- Purity (NMR): 95.0%.
- Target: PPAR; drug metabolite.
- Storage: powder -20°C for 3 years, 4°C for 2 years; in solvent -80°C for 6 months, -20°C for 1 month.
- Provided for research use only; not for human therapeutic use.
TARGETMOL CHEMICALS INC GPR40/FFAR1 MODULATOR 1 5MG
Also available in 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. GPR40/FFAR1 modulator 1 is a Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) agonist and allosteric modulator. purity: 99%
Medchemexpress LLC Iduronate 2-sulfatase | 50936-59-9 | >95.0% | 500 UG
Recombinant human iduronate 2-sulfatase (IDS) is a lysosomal enzyme produced in HEK293 cells and supplied lyophilized as an active, His-tagged protein for biochemical and enzymatic studies. It hydrolyzes the C2-sulfate ester of glycosaminoglycans and is provided with validated purity and activity specifications.
- Expressed in HEK293 cells.
- C-terminal 10xHis tag for purification.
- Purity >95.0% by reducing SDS-PAGE.
- Specific activity 6.123 pmoL/min/μg (PNCS substrate assay).
- Lyophilized from 0.22 μm filtered PBS, pH 7.4.
- Approximate molecular weight 75-95 kDa due to glycosylation.
- Store at -20°C; after reconstitution stable at 4°C for 1 week.
- Available in a 500 μg size.
Medchemexpress LLC Iduronate 2-sulfatase protein, human (HEK293, His) | >95.0% | 50 UG
Recombinant human iduronate 2-sulfatase (IDS) expressed in HEK293 cells and supplied as a C-terminal His-tagged lyophilized protein for research use. The enzyme catalyzes degradation of dermatan sulfate and heparan sulfate and is provided with high purity and defined activity for biochemical assays and protein characterization.
- Supplied as lyophilized powder for convenient storage and transport.
- Expressed in HEK293 for human-like post-translational modifications.
- C-terminal His tag enables affinity purification and detection.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Specific activity reported as 6.123 pmoL/min/μg for functional assays.
- Low endotoxin level (<1 EU/μg) suitable for sensitive applications.
- Stable at -20°C; reconstitute above 100 μg/mL and add carrier protein for long-term storage.
Medchemexpress LLC IL-17A modulator-2 | 2748749-47-3 | 98.4% | C33H31N5O5 | 25 MG
IL-17A modulator-2 is a chemical compound with the molecular formula C33H31N5O5, presented as a white to off-white solid. It has a molecular weight of 577.63 and demonstrates a purity of 98.44% (HPLC). This compound is ideal for research applications requiring a high-purity reagent, with specific storage recommendations to maintain its stability.
- White to off-white solid appearance
- Molecular formula: C33H31N5O5
- Molecular weight: 577.63
- Purity: 98.44% (HPLC)
- Solid form storage: 4°C, sealed, away from moisture and light
- In solvent storage: -80°C for 6 months or -20°C for 1 month, sealed, away from moisture and light
Medchemexpress LLC GPR120 modulator 1 | 1050506-75-6 | 98.1% | 389.85 g/mol | C19H16ClNO4S | 10 MG
GPR120 modulator 1 is a small-molecule research compound used to modulate G protein-coupled receptor 120 (GPR120) in studies of metabolic and inflammatory pathways. It is intended for in vitro and preclinical research use and is supplied as a purified solid with reported purity suitable for biochemical assays.
- Small-molecule modulator of GPR120 for receptor biology studies.
- High reported purity for reliable assay performance.
- Available in small pack sizes suitable for screening and characterization.
- Provided with supporting documents including datasheet and safety information.
Medchemexpress LLC Hydrazinecarbothioamide, 2-(1H-indol-3-ylmethylene)-N-(4-methylphenyl)-, (2E)- | 2097787-75-0 | 99.0% | 308.40 g/mol | C17H16N4S | 10 MG
Nur77 modulator 3 is a small-molecule research compound that binds nuclear receptor Nur77 (NR4A1) and modulates its activity. It has been reported to inhibit TGF-β1-induced α-SMA and COLA1 expression and to reduce hepatic stellate cell activation and extracellular matrix deposition. Technical identifiers include CAS 2097787-75-0, formula C17H16N4S, molecular weight 308.40 g/mol, and purity 99.01%.
- Modulates Nur77 activity in cellular and in vivo models.
- Inhibits TGF-β1-induced α-SMA and COLA1 expression.
- High purity (99.01%) suitable for biochemical and cell-based assays.
- Supplied in small quantities appropriate for assay development and pilot studies.
Medchemexpress LLC Sulforaphane | 4478-93-7 | 99.0% | 177.29 | 500 MG
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. It promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. By activating the Keap1/Nrf2/ARE pathway and further inducing HO-1 expression, Sulforaphane protects the heart. It suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission and exhibits both anticancer and anti-inflammatory properties.
- Orally active inducer of the Keap1/Nrf2/ARE pathway.
- Promotes transcription of tumor-suppressing proteins.
- Effectively inhibits HDACs activity.
- Protects the heart.
- Suppresses high glucose-induced pancreatic cancer.
- Exhibits anticancer and anti-inflammatory properties.
- Induces cell cycle arrest and apoptosis.
- Reduces ROS production and cell apoptosis.
Medchemexpress LLC Sulindac sulfide | 49627-27-2 | MFCD00078044 | 98.1% | 1 ML
Sulindac sulfide is a noncompetitive γ-secretase inhibitor, demonstrating an IC50 of 20.2 μM for γ42-secretase activity. This compound is primarily utilized in neurological disease research, targeting drug metabolites and γ-secretase.
- Noncompetitive γ-secretase inhibitor
- IC50 of 20.2 μM for γ42-secretase activity
- Targeted for drug metabolite research
- Used in neurological disease studies