Sulfoxides
Medchemexpress LLC Sonidegib metabolite 50mg | 1221722-10-6 | 296.24 g·mol⁻¹ | C15H11F3O3 | 50 MG
Sonidegib metabolite M48 (2-methyl-3-[4-(trifluoromethoxy)phenyl]benzoic acid) is the primary circulating metabolite of sonidegib, supplied as a research-grade reference standard for pharmacokinetic, metabolic, and analytical studies.
- For research use only; not for human or clinical use.
- High purity: 98.0%.
- White to off-white solid, stable under recommended storage.
- Comprehensive analytical data available (COA, HNMR, LC-MS).
- Recommended storage: room temperature (solid) for up to 3 years; in solvent: -80°C for 2 years, -20°C for 1 year.
- Suitable as a reference standard for PK and metabolism studies.
Medchemexpress LLC IRAK4 modulator-2 | 1356013-27-8 | 99.9% | 399.87 | 5 MG
IRAK4 modulator-2 | 1356013-27-8 | 99.9% | 399.87 | 5 MG
Medchemexpress LLC GLP-1R modulator L7-028 | 2648317-95-5 | 99.47% | C24H28N2O3 | 100 MG
GLP-1R modulator L7-028 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site (EC50 11.01 ± 2.73 μM). It is intended for research use only.
- Available as a solid, white to off-white in color.
- Soluble in DMSO at 100 mg/mL.
- Shipped at room temperature in continental US.
Medchemexpress LLC Fast garnet GBC sulfate salt | 101-89-3 | MFCD00011883 | 90.0% | 334.35 g/mol | C14H14N4O4S | 50 MG
Fast garnet GBC sulfate salt, 90% is an azo diazonium dye used as a chromogenic substrate for alkaline phosphatase in histochemical staining and related enzymatic assays. It is supplied as a sulfate salt with high dye content suitable for laboratory staining protocols.
- Chromogenic substrate for alkaline phosphatase staining
- High dye content, formulated at 90.0% purity
- Suitable for histochemistry and enzyme activity assays
- Available in small laboratory-scale quantities
- Solid form with molecular formula C14H14N4O4S
Sigma Aldrich Fine Chemicals Biosciences Succinylcholine Chloride P1G
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Medchemexpress LLC MRGPRX4 modulator-1 (compound 31-2) | 2492596-61-7 | 98.1% | 359.73 g·mol⁻¹ | C16H13ClF3NO3 | 5 MG
MRGPRX4 modulator-1 is a small-molecule antagonist of the Mas-related G-protein coupled receptor X4 (MRGPRX4) intended for in vitro and preclinical research into itch, pain, and immune-related pathways. The compound is supplied as a solid and as a DMSO solution and is characterized by potency suitable for biochemical and cellular assays.
- Antagonist activity with IC50 <100 nM for MRGPRX4.
- Molecular formula C16H13ClF3NO3 and molecular weight 359.73 g·mol⁻¹.
- High purity around 98% as reported in documentation.
- Available as solid milligram quantities and as a 10 mM solution in DMSO.
- Appearance white to light yellow solid.
- Storage: powder at -20°C (long term) or 4°C (short term); in solvent at -80°C or -20°C for shorter periods.
- Intended for biochemical and cellular research into itch, pain, and immune pathways.
Medchemexpress LLC GLP-1R modulator C5 | 421578-93-0 | 99.8% | C24H21NO3 | 10MG
GLP-1R modulator C5 is a small-molecule allosteric modulator that enhances GLP-1 binding to the GLP-1 receptor via a transmembrane site. It is intended for research use and is characterized by an EC50 of 1.59 ± 0.53 μM, molecular formula C24H21NO3, and molecular weight 371.43 g·mol⁻1.
- Allosteric enhancer of GLP-1 binding to GLP-1R.
- Measured EC50 of 1.59 ± 0.53 μM.
- Available as solid (5-100 mg) and 10 mM solution in DMSO.
- High purity (99.81% by LCMS).
- Supplied with certificate of analysis for analytical verification.
Medchemexpress LLC IL-17 modulator 4 | 2446803-65-0 | >99.0% | C27H34N6O2 | 1 ML
IL-17 modulator 4 is a proagent of IL-17 modulator 1, active against IL-17A mediated diseases. This orally active modulator shows promise for the research of conditions including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome. It inhibits IL-17A-mediated signaling pathways by stabilizing the IL-17A dimer and preventing its binding to the IL-17RA receptor.
- Modulates IL-17A protein-protein interaction
- Stabilizes IL-17A dimer conformation
- Prevents IL-17A from binding to IL-17RA receptor
- Inhibits IL-17A-mediated signaling pathways
- Exhibits good pharmacokinetic properties in rat models
- Oral bioavailability of 100% in rat models
Medchemexpress LLC Cytochrome P450 17A1 Antibody (YA478) | 57 kDa | 10 UL
This Cytochrome P450 17A1 Antibody (YA478) is supplied as a liquid and is suitable for various laboratory applications. It is stable under recommended storage conditions and intended for research use only.
- Host: Rabbit
- Reactivity: Human, mouse, rat
- Clonality number: YA478
- SwissProt ID: P05093
- Gene ID: 1586
- Appearance: Liquid
- Concentration: 1.0 mg/mL
- Conjugation: Non-conjugated
- Application: WB, ICC/IF, IHC-P, FC
- Dilution ratio: WB: 1:500; ICC/IF: 1:50-1:200; IHC-P: 1:50-1:200; FC: 1:50-1:100
- Formulation: Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
- Storage: Stored at -20°C for 1 year. Avoid repeated freeze/thaw cycles.
- Shipping: Shipping with blue ice.
- Molecular weight: 57 kDa
TARGETMOL CHEMICALS INC NOT Receptor Modulator 1 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes.NOT Receptor Modulator 1 (2-(3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol) is a modulator of nuclear receptor NOT. Purity 97.01%
Medchemexpress LLC Cytochrome P450 1B1 antibody (YA1836) | 10 UL
Cytochrome P450 1B1 antibody (YA1836) is a rabbit-derived, non-conjugated IgG monoclonal antibody targeting Cytochrome P450 1B1. It is intended for research use only.
- Rabbit host
- Recombinant, monoclonal
- Species reactivity: Human, mouse, rat
- Immunogen: A synthesized peptide derived from human CYP1B1 aa400-543
- Isotype: IgG
- Appearance: Liquid
- Formulation: Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
- Storage & stability: Stored at -20°C for 1 year. Avoid repeated freeze/thaw cycles
- Shipping: Shipping with blue ice
- Applications & dilution ratios: WB (Western Blot): 1:500-1:1000, IHC-P (Immunohistochemistry-Paraffin): 1:50-1:100, FC (Flow Cytometry): 1:50-1:100
- Sensitivity: Endogenous
- Conjugation: Non-conjugated
- Modification: Unmodified
Medchemexpress LLC Cytochrome P450 24A1 Antibody (YA2121) | 50 UL
Cytochrome P450 24A1 Antibody (YA2121) is a rabbit-derived, non-conjugated IgG monoclonal antibody specifically targeting Cytochrome P450 24A1. This antibody is intended for research use only. Cytochrome P450 24A1 is a monooxygenase crucial for vitamin D catabolism and calcium homeostasis, inactivating calcidiol and calcitriol via C24- and C23-oxidation pathways.
- Host: Rabbit
- Clonality: Monoclonal
- Conjugation: Non-conjugated
- Isotype: IgG
- Appearance: Liquid
- Purity: Affinity chromatography
- Application: Western blot (WB)
- Dilution ratio: 1:500-1:1000
- Species reactivity: Human
- Molecular weight: 59 kDa (predicted and observed)
- Subcellular localization: Mitochondrion
- Research field: Cardiovascular
Medchemexpress LLC KAT modulator-1 | 1314006-43-3 | C20H36O2 | 50 MG
KAT modulator-1 is a laboratory chemical identified for research use only. It has a molecular formula of C20H36O2 and a molecular weight of 308.50. This substance appears as a solid and is considered stable under recommended storage conditions, though it has not been fully validated for medical applications.
- Not classified as a hazardous substance
- Stable under recommended storage conditions
- Store in a tightly sealed container in a cool, well-ventilated area
- Avoid direct sunlight and ignition sources
- Recommended powder storage: -20°C for 3 years, 4°C for 2 years
- Recommended in-solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Sulforaphane | 4478-93-7 | 99.75% | 177.29 | 200 MG
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. It promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. It protects the heart through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission and exhibits both anticancer and anti-inflammatory properties.
- Targets: HDAC, Keap1-Nrf2, Apoptosis, Bcl-2 family, Caspase, Reactive oxygen species (ROS)
- Research areas: Inflammation/Immunology, Cancer