Sulfoxides
Sigma Aldrich Tetrahydrothiophene
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
![Medchemexpress LLC 2(3h)-benzothiazolone, 6-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-3-methyl | 142477-34-7 | 97.1% | 383.51 g/mol | C21H25N3O2S | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000214116.png-250.jpg)
Medchemexpress LLC 2(3h)-benzothiazolone, 6-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-3-methyl | 142477-34-7 | 97.1% | 383.51 g/mol | C21H25N3O2S | 1 MG
A selective small-molecule research ligand for the 5-HT1A serotonin receptor that also exhibits activity at adrenergic α1 and dopamine D2 receptors. Supplied as a white to off-white solid with supporting analytical documentation (COA and datasheet) for preclinical pharmacology and receptor profiling studies.
- High affinity for 5-HT1A receptor, IC50 ≈ 2 nM.
- Measured off-target activity at adrenergic α1 and dopamine D2 receptors (IC50 ≈ 10 nM and 40 nM).
- Supplied as a stable solid suitable for frozen or refrigerated storage.
- Certificate of analysis and purity data available to support assay reproducibility.
- Useful as a pharmacological tool for serotonin receptor profiling and CNS research.
Medchemexpress LLC (+)-LRH-1 modulator-1 | 00-00-0 | 99.4% | C28H36N2O2S | 10MG
(+)-LRH-1 modulator-1 is the (+)-stereoisomer of an LRH-1 modulator and functions as a potent agonist of liver receptor homolog-1 (LRH-1). It modulates inflammatory signaling in intestinal organoid models by inducing IL-10 and reducing IL-1β and TNFα. The compound is provided as a high-purity research-grade small molecule for cellular and biochemical studies of LRH-1 pathways.
- Potent LRH-1 modulator/agonist for receptor pharmacology studies.
- Induces anti-inflammatory cytokine IL-10 in organoid models.
- Reduces proinflammatory cytokines IL-1β and TNFα in assays.
- High purity suitable for cellular and biochemical experiments.
- Available in multiple small-scale quantities for research use.
Cayman Chemical Sulindac Inhibitors
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
Apexbio Technology LLC Sulforaphane(Synonyms: Broccoli sulforaphane, DL-Sulforaphane, R-Sulforaphane, 1-Isothiocyanato-4-(methylsulfinyl)butane), 25mg, CAS: 4478-93-7.
Sulforaphane (CAS 4478-93-7) is a naturally occurring isothiocyanate abundantly found in vegetables especially broccoli It acts primarily through activation of the Keap1-Nrf2 signaling pathway enhancing cellular defense against oxidative and electrophilic stress Sulforaphane has demonstrated antiproliferative activity in vitro as shown by dose-dependent cell cycle arrest at G2/M and apoptosis induction in HT29 human colon carcinoma cells Such effects involve elevated cyclin A and B1 levels increased pro-apoptotic Bax expression mitochondrial cytochrome c release and poly(ADP-ribose) polymerase cleavage These properties make sulforaphane relevant for investigating cancer chemoprevention and cellular stress responses