Thioureas
AdipoGen Budesonide
Chemical. CAS 51333-22-3. Formula C25H34O6. MW 430.5. Budesonide is a glucocorticoid and an agonist of glucocorticoid receptors EC50=45.7pM in a transactivation assay, selective for glucocorticoid over mineralocorticoid receptors. Budesonide is a synthetic anti-inflammatory agent that displays chemopreventive activity. It is used as an anti-inflammatory agent in the treatment of asthma, rhinitis and inflammatory bowel disease and is evaluated in prevention of lung cancer. It prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. It also reverses DNA hypomethylation and modulates expression of cancer related genes. Due to its potent activity, as an inhaled glucocorticoid, in reducing airway inflammation, Budesonide has potential as treatment for early COVID-19 infection.
eMolecules Oakwood Chemicals Thiourea 1kg 480131782 044741 0 000 62-56-6 MFCD00008067 76 120 CH4N2S
Oakwood Chemicals Thiourea 1kg 480131782 044741 0 000 62-56-6 MFCD00008067 76 120 CH4N2S
AdipoGen Desacetylcolchicine tartrate
Chemical. CAS 49720-72-1. Formula C20H23NO5 . C4H6O6. MW 357.4 . 150.1. Synthetic. Anticancer colchicine analog. Microtubule polymerization inhibitor. Prevents cell division.
AdipoGen L-Alanyl-L-glutamine
Chemical. CAS 39537-23-0. Formula C8H15N3O4. MW 217.22. Synthetic. L-Glutamine is an essential supplement for cell culture. The free amino acid L-glutamine is unstable and degrades to pyroglutamate. Alanyl-L-glutamine Ala-Gln and Gylcyl-L-glutamine Gly-Gln are used in cell culture media as alternative delivery forms of stabilized L-glutamine. Alanyl-glutamine is a widely used alternative supplement to L-glutamine in the production of biopharmaceuticals, cosmetics and food products. Alanyl-glutamine also acts as an antioxidant peroxide and anti-apoptosis LPS-induced factor. Ala-Gln has been used in studies on injury and sepsis, and on the effects of irradiation on leucine and protein metabolism in vivo. Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro. Shown to improve intestinal health and enhances the immune system. It is also involved in various clinical studies such as cancer treatment, radiation and chemotherapy.
Chem-Impex International, Inc. Thiourea | 62-56-6 | MFCD00008067 | 1KG
Thiourea, 62-56-6, MFCD00008067, 1KG
AdipoGen Z-Leu-Leu-Nva-CHO MG-115
Chemical. CAS 133407-86-0. Formula C25H39N3O5. MW 461.6. Potent, reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Calpain and cathepsin inhibitor. Apoptosis inducer in Rat-1 and PC12 cells via a p53-dependent pathway. Autophagy activator.
AdipoGen Alsterpaullone
Chemical. CAS 237430-03-4. Formula C16H11N3O3. MW 293.3. Potent CDK1/cyclin B IC50 = 35 nM inhibitor. Anti-tumor compound Potent inhibitor of CDK2/cyclin A, CDK2/cyclin E IC50 = 200 nM, CDK5/p25 IC50 = 40 nM, CDK5/p35 IC50 = 40 nM. GSK-3beta glycogen synthase kinase-3beta inhibitor. Apoptosis inhibitor. Apoptosis inducer. Angiogenesis inhibitor.
AdipoGen Desacetylcolchicine tartrate
Chemical. CAS 49720-72-1. Formula C20H23NO5 . C4H6O6. MW 357.4 . 150.1. Synthetic. Anticancer colchicine analog. Microtubule polymerization inhibitor. Prevents cell division.
AdipoGen L-Alanyl-L-glutamine
Chemical. CAS 39537-23-0. Formula C8H15N3O4. MW 217.22. Synthetic. L-Glutamine is an essential supplement for cell culture. The free amino acid L-glutamine is unstable and degrades to pyroglutamate. Alanyl-L-glutamine Ala-Gln and Gylcyl-L-glutamine Gly-Gln are used in cell culture media as alternative delivery forms of stabilized L-glutamine. Alanyl-glutamine is a widely used alternative supplement to L-glutamine in the production of biopharmaceuticals, cosmetics and food products. Alanyl-glutamine also acts as an antioxidant peroxide and anti-apoptosis LPS-induced factor. Ala-Gln has been used in studies on injury and sepsis, and on the effects of irradiation on leucine and protein metabolism in vivo. Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro. Shown to improve intestinal health and enhances the immune system. It is also involved in various clinical studies such as cancer treatment, radiation and chemotherapy.
AdipoGen 1 5-Isoquinolinediol
Chemical. CAS 5154-02-9. Formula C9H7NO2. MW 161.2. PARP-1 inhibitor. Neuroprotectant. Blocks nitric oxide-induced neuronal toxicity. Potent iNOS inducible nitric oxide synthase/NOS II inhibitor. Stimulates homologous recombination.
AdipoGen Efavirenz
Chemical. CAS 154598-52-4. Formula C14H9ClF3NO2. MW 315.7. Efavirenz is a non-nucleoside reverse transcriptase inhibitor NNRTI that exhibits antiviral and anticancer activities. Efavirenz binds to wild-type and mutant HIV-1 RTs Ki= 2.93nM and 3.85-56.5nM, respectively. It inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells IC95s = 1.5-1,500 nM. Efavirenz also prevents RNA plus-strand initiation with an IC50 value of 17nM. Efavirenz is an anti-HIV drug, commonly used in combination therapy for AIDS treatment. It is part of highly active antiretroviral therapy HAART for the treatment of a human immunodeficiency virus HIV type 1. In various cancer cell lines, Efavirenz inhibits cellular proliferation and increases activation of p53. CARD8 inflammasome senses HIV-1 protease activity. In HIV1-infected cells, CARD8 cannot detect the virus because the viral protease remains inactive as a subunit of unprocessed Gag-Pol polyprotein.
eMolecules Chem-Impex Thiourea 1kg 112439616 00284 0 000 62-56-6 MFCD00008067 76 120 CH4N2S
Chem-Impex Thiourea 1kg 112439616 00284 0 000 62-56-6 MFCD00008067 76 120 CH4N2S
AdipoGen 7b-OH-cholesteryl-bishemisucci
Chemical. CAS 105449-93-2. Formula C35H54O8 . 2C2H7NO. MW 602.80 . 61.08. Synthetic Water-soluble derivatives of 7beta-hydroxycholesterol. Anticancer compound, inducing apoptosis in various solid tumor cell lines.