Thioureas
AdipoGen Z-Leu-Arg-Gly-Gly-AMC
Chemical. CAS 167698-68-2 free base. Formula C34H44N8O8 . C2HF3O2. MW 692.8 . 114.0. Fluorogenic tetrapeptide substrate for ubiquitin C-terminal hydrolases UCHs, e.g. UCHL3 and isopeptidase T. LRGG is the preferred substrate sequence of the human deSUMOylating enzymes SENP6 and SENP7. Excitation 380nm. Emission 460nm.
AdipoGen 1-Methyltryptamine
Chemical. CAS 7518-21-0. Formula C11H14N2. MW 174.24. Synthetic. Deacetylase inhibitor.
eMolecules 62-56-6 | Thiourea | Chem-Impex | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 5kg | 342448903
Thiourea | Chem-Impex | 62-56-6 | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 5kg | 342448903
eMolecules 62-56-6 | Thiourea | Oakwood Chemicals | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 25kg | 480131784
Thiourea | Oakwood Chemicals | 62-56-6 | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 25kg | 480131784
AdipoGen Triptolide
Chemical. CAS 38748-32-2. Formula C20H24O6. MW 360.4. Synthetic. Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II Pol II and by inhibiting the ATPase activity of XPB a subunit of the general transcription factor TFIIH. Interferes with a number of transcription factors including p53, NF-kappaB, nuclear factor of activated T cells NFAT and heat shock factor protein 1 HSF-1. Shown to inhibit aromatase activity.
AdipoGen PJ-34
Chemical. CAS 344458-15-7. Formula C17H17N3O2 . HCl. MW 295.2 . 36.5. Potent, water soluble polyADP-ribose polymerase PARP inhibitor. Inhibits peroxynitrite-induced cell necrosis. Shows significant, dose-dependent anti-inflammatory effects in a variety of local inflammation models. Provides cardioprotection by decreasing myocardial infarct size. Shows protective effects in models of stroke. Suppresses cell growth in liver cancer cells.
Biomatik Corporation DNase II, Porcine Pancreas, 12000 Kunitz U/MG. Grade Biotechnology. Storage -20C. CAS 9025-64-3
DNase II, Porcine Pancreas, 12000 Kunitz U/MG. Grade Biotechnology. Storage -20C. CAS 9025-64-3
eMolecules 6325-91-3 | 2-Mercapto-5-nitrobenzimidazole | MFCD00804727 | 25g
Combi-Blocks | 2-Mercapto-5-nitrobenzimidazole | 25g | 335354889 | QF-9095 | 95.000 | 6325-91-3 | MFCD00804727 | 195.200 | C7H5N3O2S
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AdipoGen DMNQ
Chemical. CAS 6956-96-3. Formula C12H10O4. MW 218.2. Cell permeable, non-alkylating, non-thiol, adduct-forming, redox cycling quinone. Intracellular superoxide anion formation/ROS generation inducer. Anticancer agent. Shown to induce cell proliferation, apoptosis, necrosis and necroptosis in vitro, dependent on concentration, time, temperature and cell type. Valuable tool for the generation of reactive oxygen species ROS in order to study the role of ROS in cell toxicity, apoptosis and necrosis. Useful as reference compound in characterizing the effects of oxidative stress. Can be used to eliminate any mechanistic ambiguity involving redox cycling quinoids as the source of reactive oxidant species/oxidative stress in biological studies.
AdipoGen Ixazomib MLN2238
Chemical. CAS 1072833-77-2. Formula C14H19BCl2N2O4. MW 361. Synthetic. Potent selective and reversible proteasome inhibitor all proteolytic subunits. Targets the chymotrypsin-like beta5 subunit of the constitutive 20S proteasome IC50=3.4nM. Cross-reacts and inhibits the trypsin-like beta2 subunit IC50=3.5µM and the caspase-like/peptidyl-glutamyl peptide-hydrolyzing PGPH beta1 subunit IC50=0.03µM. Anticancer compound effective in cell-based assays, in xenografts and against multiple myeloma in vivo. In vitro, induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma. Biologically active form of the prodrug MLN9708 AG-CR1-3671. Exhibits improved pharmacodynamics and antitumor activity compared to bortezomib in various B-cell lymphoma models, due to a greater tumor to blood ratio of proteasome inhibition that ultimately translates into improved tumor pharmacodynamic response and antitumor activity in several tumor xenograft models.
eMolecules 62-56-6 | Thiourea | Oakwood Chemicals | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 10kg | 480131783
Thiourea | Oakwood Chemicals | 62-56-6 | MFCD00008067 | 76.120 | CH4N2S | 99.000 | NC(N)=S | 10kg | 480131783
AdipoGen PTACH
Chemical. CAS 848354-66-5. Formula C20H26N2O2S2. MW 390.56. Synthetic. Non-hydroxamate HDAC inhibitor HDACi IC50 32, 48 and 41nM for HDAC4, HDAC1 and HDAC6, respectively. Cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor. Predicted to exhibit a similar HDAC binding mode as that of SAHA, interacting with the active-site zinc targeting group. Shown to exhibit comparable antiproliferative and apoptotic activity as SAHA against various cancer cell lines. Inhibits growth of various cancer cells in vitro EC50 = 1.1 - 9.1mM. Also reactivates latent HIV-1 gene expression.
eMolecules 614-78-8 | N-(2-Methylphenyl)thiourea | Chem-Impex | MFCD00041162 | 166.240 | C8H10N2S | 98.000 | Cc1ccccc1NC(N)=S | 1g | 254750059
N-(2-Methylphenyl)thiourea | Chem-Impex | 614-78-8 | MFCD00041162 | 166.240 | C8H10N2S | 98.000 | Cc1ccccc1NC(N)=S | 1g | 254750059
AdipoGen 7b-OH-cholesteryl-bishemisucci
Chemical. CAS 105449-93-2. Formula C35H54O8 . 2C2H7NO. MW 602.80 . 61.08. Synthetic Water-soluble derivatives of 7beta-hydroxycholesterol. Anticancer compound, inducing apoptosis in various solid tumor cell lines.
AdipoGen C646
Chemical. CAS 328968-36-1. Formula C24H19N3O6. MW 445.4. Reversible cell permeable p300/CBP histone acetyltransferase HAT inhibitor. Specific inhibition to p300 86% compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases <10%. Cell growth inhibitor in melanoma and non-small-cell-lung NSCL human cancer cell lines.