Anthracyclines
Apexbio Technology LLC Doxorubicin (Adriamycin) HCl 25316-40-9 10mM (in 1mL DMSO)
Doxorubicin hydrochloride an anthracycline antibiotic derivative exhibits cytotoxic activity and is widely utilized as an anticancer chemotherapeutic agent Its mechanism involves intercalating into DNA double-strands inhibiting DNA topoisomerase II activity and consequently interrupting replication processes causing DNA damage and altered chromatin structure by histone displacement In biomedical research settings doxorubicin hydrochloride is employed in vitro and in animal models to study therapeutic strategies against hematologic malignancies solid tumors and sarcomas Reported IC50 values vary with cell type and assay conditions typically ranging between approximately 0 1 M to 2 M in various tumor-derived cell models
Apexbio Technology LLC BIIE 0246 246146-55-4 1mg
BIIE 0246 (CAS 246146-55-4) is a potent and selective antagonist of the neuropeptide Y Y2 receptor (Y2R) a G protein-coupled receptor involved in presynaptic inhibition within the central and peripheral nervous systems BIIE 0246 exhibits high affinity for Y2R with an IC50 of 3 3 nM in radioligand binding assays and Ki values between 8 15 nM in HEK293 cells expressing rat Y2 receptors In hippocampal slices BIIE 0246 (100 nM) reverses NPY-induced inhibition of excitatory postsynaptic potentials In vivo administration in rats attenuates PYY(3-36)-mediated suppression of food intake and increases feeding in satiated animals supporting its use in research on appetite regulation and anxiety-related behavior
Apexbio Technology LLC Doxorubicin 23214-92-8 100mg
Doxorubicin is an anthracycline antibiotic commonly used as an anti-cancer agent targeting DNA replication machinery Its mechanism of action involves intercalation into DNA double helices and subsequent inhibition of DNA topoisomerase II impeding DNA synthesis and causing genomic instability Additionally Doxorubicin mediates chromatin remodeling by facilitating histone displacement from active chromatin contributing further to DNA damage and transcriptional dysregulation It is extensively employed in studies involving hematologic malignancies solid tumors and sarcomas frequently serving as a chemotherapeutic reference compound In biochemical assays Doxorubicin has demonstrated inhibitory effects on Topoisomerase II with an IC50 typically ranging between 1-10 M depending on assay conditions and cell lines applied
Apexbio Technology LLC Daunorubicin 20830-81-3 50mg
Daunorubicin (20830-81-3) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit this target thereby disrupting nucleic acid synthesis within tumor cells Daunorubicin exerts its biological activity primarily through stabilizing the topoisomerase II-DNA cleavage complex interfering with DNA replication and transcription In in vitro studies daunorubicin demonstrates inhibition of metabolic incorporation of nucleoside precursors into DNA and RNA with reported IC50 values for inhibition of leukemia cell growth ranging from 0 02 1 M depending on cellular context and assay conditions Based on these pharmacological properties daunorubicin holds research potential in oncology studies related to chemotherapy-induced genotoxicity and nucleic acid metabolism
Apexbio Technology LLC Daunorubicin HCl 23541-50-6 10mM (in 1mL DMSO)
Daunorubicin HCl (CAS 23541-50-6) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit topoisomerase II thereby disrupting nucleic acid synthesis and interfering with DNA replication and transcription Daunorubicin HCl exerts its biological activity primarily through stabilization of DNA-topoisomerase II complexes In in vitro studies daunorubicin exhibits cytotoxic effects with IC50 values typically ranging from 0 1 to 1 M in common leukemia cell assays Based on these pharmacological properties daunorubicin HCl holds research potential in oncology particularly for studying acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
Apexbio Technology LLC Daunorubicin HCl 23541-50-6 10mg
Daunorubicin HCl (CAS 23541-50-6) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit topoisomerase II thereby disrupting nucleic acid synthesis and interfering with DNA replication and transcription Daunorubicin HCl exerts its biological activity primarily through stabilization of DNA-topoisomerase II complexes In in vitro studies daunorubicin exhibits cytotoxic effects with IC50 values typically ranging from 0 1 to 1 M in common leukemia cell assays Based on these pharmacological properties daunorubicin HCl holds research potential in oncology particularly for studying acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)
Selleck Chemical LLC Doxorubicin-5mg
Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication, and induces apoptosis, also inhibits human DNA topoisomerase I with an IC50 of 0.8 μM.
Sigma Aldrich Fine Chemicals Biosciences Doxorubicin hydrochloride50MG
Chemical structure tetracycline
Research Products International Corp Doxorubicin HCl Powder 5 MG
Doxorubicin Hydrochloride is a potent chemotherapeutic agent. It intercalates with DNA, inhibiting nucleic acid synthesis, and also generates free radicals that cause DNA strand breaks. These actions disrupt the replication and transcription processes, leading to cell death. It also generates free radicals that can cause DNA damage and induce apoptosis (programmed cell death) in cancer cells.
Doxorubicin is widely used in cancer research as a tool to study cellular responses to DNA damage, apoptosis, and mechanisms of drug resistance.
WARNING! This product can expose you to Doxorubicin HCl, a chemical which is known to the State of California to cause developmental harm. For more information go to www.P65Warnings.ca.gov.
TARGETMOL CHEMICALS INC Doxorubicin hydrochloride
Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 uM). Doxorubicin hydrochloride exhibits cytotoxicity and antitumor activity. Doxorubicin hydrochloride reduces the phosphorylation of AMPK and its downstream target protein acetyl coenzyme A carboxylase, and induces apoptosis and autophagy. Purity 99.57%
Medchemexpress LLC Doxorubicin hydrochloride | 25316-40-9 | MFCD00077757 | 99.3% | 579.98 g/mol | C27H30ClNO11 | 10 MG
Doxorubicin hydrochloride is an anthracycline antibiotic with cytotoxic activity supplied as a high-purity analytical standard for laboratory research. It functions as a DNA intercalator and inhibits topoisomerases I and II, making it useful as a biochemical reagent and reference in cell-based assays and analytical method development.
- High purity (99.33%) suitable for analytical applications.
- Confirmed identity: CAS 25316-40-9, molecular weight 579.98 g/mol.
- Available in multiple package sizes, including 10 mg.
- Acts as a DNA intercalator and topoisomerase I/II inhibitor.
- Suitable for biochemical assays, cell-based studies, and analytical standards.
Medchemexpress LLC BIIE-0246 | 246146-55-4 | 99.1% | 896.05 g·mol⁻¹ | C49H57N11O6 | 1 ML
BIIE-0246 is a potent, selective non-peptide antagonist of the neuropeptide Y Y2 receptor (NPY2R) used in preclinical neuroscience research. It has an IC50 of approximately 15 nM (rat [125I]PYY3-36) and modulates downstream signaling pathways including p-AKT and p44/42 MAPK. The compound is supplied as a 10 mM solution in DMSO with reported high purity for research use only.
- Potent NPY Y2 receptor antagonist (IC50 ~15 nM).
- Ready-to-use 10 mM solution in DMSO for in vitro assays.
- High reported purity (99.1%).
- Molecular weight 896.05 g·mol⁻¹ and formula C49H57N11O6.
- Suitable for studies of NPY2R signaling and related pathways.
Sigma Aldrich Fine Chemicals Biosciences Apoatropine hydrochloride10MG
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity water residual solvents inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH Co. KG
Medchemexpress LLC BIIE-0246 (AR-H 053591) | 246146-55-4 | 99.1% | 896.05 g/mol | C49H57N11O6 | 100 MG
BIIE-0246 (AR-H 053591) is a potent, selective non-peptide antagonist of the neuropeptide Y Y2 receptor used as a research reagent to probe NPY2R-mediated signaling. It is provided as a solid powder for in vitro and in vivo applications, with a reported IC50 of approximately 15 nM (rat [125I]PYY3-36). Intended for research use only.
- Potent, selective NPY Y2 receptor antagonist (IC50 ≈ 15 nM).
- Supplied as a solid powder suitable for in vitro and in vivo studies.
- High purity (reported ≥99.1%).
- Available in multiple pack sizes and solution formats for convenience.
- Intended for research use only; not for human or clinical use.