Anthracyclines
Apexbio Technology LLC Doxorubicin (Adriamycin) HCl 25316-40-9 10mg
Doxorubicin hydrochloride an anthracycline antibiotic derivative exhibits cytotoxic activity and is widely utilized as an anticancer chemotherapeutic agent Its mechanism involves intercalating into DNA double-strands inhibiting DNA topoisomerase II activity and consequently interrupting replication processes causing DNA damage and altered chromatin structure by histone displacement In biomedical research settings doxorubicin hydrochloride is employed in vitro and in animal models to study therapeutic strategies against hematologic malignancies solid tumors and sarcomas Reported IC50 values vary with cell type and assay conditions typically ranging between approximately 0 1 M to 2 M in various tumor-derived cell models
Medchemexpress LLC Doxorubicin hydrochloride | 25316-40-9 | C₂₇H₃₀ClNO₁₁ | 5 MG
Doxorubicin hydrochloride is a cytotoxic anthracycline antibiotic and an anti-cancer chemotherapy agent. It is a potent human DNA topoisomerase I and topoisomerase II inhibitor, reducing basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. It also induces apoptosis and autophagy.
- Potent human DNA topoisomerase I and topoisomerase II inhibitor
- Reduces basal phosphorylation of AMPK
- Induces apoptosis and autophagy
- Used in infection and cancer research
Sigma Aldrich Fine Chemicals Biosciences Cathine hydrochloride5MG
hydrochloride Cathine hydrochloride5MG
Medchemexpress LLC Daunorubicin hydrochloride | 23541-50-6 | 99.7% | 500 MG
Daunorubicin hydrochloride, also known as Daunomycin, is a potent topoisomerase II inhibitor with significant anti-tumor activity. This anthracycline antibiotic functions by inhibiting DNA and RNA synthesis, leading to the suppression of cancer cell viability. It is recognized for its ability to induce apoptosis and necrosis in target cells.
- Potent anti-tumor agent
- Inhibits DNA and RNA synthesis
- Induces apoptosis and necrosis
- Anthracycline antibiotic
- Useful in research for various cancers, including leukemia and lymphomas
Sigma Aldrich Fine Chemicals Biosciences Doxorubicin hydrochloride50MG
Chemical structure tetracycline
Medchemexpress LLC Doxorubicin (hydrochloride) | 25316-40-9 | MFCD00077757 | C27H30ClNO11 | 5 G
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. It is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. It also induces apoptosis and autophagy.
- Cytotoxic anthracycline antibiotic
- Anti-cancer chemotherapy agent
- Potent human DNA topoisomerase I and topoisomerase II inhibitor (IC50s of 0.8 μM and 2.67 μM)
- Reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase
- Induces apoptosis and autophagy
Medchemexpress LLC Doxorubicin (hydrochloride) | 25316-40-9 | C27H30ClNO11 | 100 MG
Doxorubicin hydrochloride (Standard) is an analytical standard and cytotoxic anthracycline antibiotic, primarily used as an anti-cancer chemotherapy agent. It functions as a potent human DNA topoisomerase I and topoisomerase II inhibitor, reducing basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase, while also inducing apoptosis and autophagy.
- Intended for research and analytical applications
- Functions as a cytotoxic anthracycline antibiotic
- Acts as an anti-cancer chemotherapy agent
- Potent human DNA topoisomerase I and II inhibitor
- Induces apoptosis and autophagy
- Used in qualitative and quantitative research experiments
- Suitable for HPLC, GC, and MS applications
