Cinnamic acids and derivatives
Selleck Chemical LLC AMG-458 S2747-50mg
AMG 458 is a potent c-Met inhibitor with Ki of 1 2 nM 350-fold selectivity for c-Met than VEGFR2 in cells
Medchemexpress LLC Tyrphostin AG1433 | 168835-90-3 | 99.1% | 1 ML
Tyrphostin AG1433 is a small-molecule tyrosine kinase inhibitor selective for PDGFRβ, supplied as a 10 mM solution in DMSO (1 mL) for research use. The compound has molecular formula C16H14N2O2 and molecular weight 266.29 g·mol⁻¹.
- Supplied as a 10 mM solution in DMSO, 1 mL.
- High purity (≈99.1%) suitable for biological research.
- Molecular formula C16H14N2O2; molecular weight 266.29 g·mol⁻¹.
- Also available as solid in multiple milligram quantities for custom preparations.
- For research use only; not for human or veterinary applications.
Apexbio Technology LLC Tyrphostin A1 2826-26-8 50mg
Tyrphostin A1 (CAS 2826-26-8) is a small molecule inhibitor targeting tyrosine kinase activity specifically involved in disrupting intracellular signaling pathways in immune cells It has been shown to interfere with CD40 ligand-induced signaling resulting in suppressed interleukin-12 (IL-12) secretion by macrophages and reduced differentiation of antigen-induced T helper 1 (Th1) cells Tyrphostin A1 is widely utilized in studies investigating cell-to-cell signaling immune response modulation and the mechanisms underlying inflammatory processes particularly in the context of autoimmune disease models
Selleck Chemical LLC Curcumin analog C1
Curcumin analog C1 (Curcumin analog Compound C1) is a potent transcription factor EB (TFEB) activator with promise for the prevention or treatment of Alzheimer s disease
Selleck Chemical LLC Curcumin S1848-1g
Curcumin (Diferuloylmethane Natural Yellow 3 Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric which is a member of the ginger family (Zingiberaceae) It is an inhibitor of p300 histone acetylatransferase IC50 25 M and Histone deacetylase (HDAC) activates Nrf2 pathway and supresses the activation of NF- B Curcumin induces mitophagy autophagy apoptosis and cell cycle arrest with antitumor activity Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus hepatitis C virus HIV and so on
eMolecules 3-Isobutoxy-4-methoxyphenylboronic acid | 1629972-11-7 | MFCD12756417 | 1g
Combi-Blocks | 3-Isobutoxy-4-methoxyphenylboronic acid | 1g | 117524383 | BB-6003 | 98.000 | 1629972-11-7 | MFCD12756417 | 224.060 | C11H17BO4
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Apexbio Technology LLC Curcumin(Synonyms: Diferuloylmethane, Turmeric yellow, Natural yellow 3, CI 75300), 10mM (in 1mL DMSO), CAS: 458-37-7.
Curcumin (CAS 458-37-7) is a natural small molecule known to inhibit tyrosinase activity with an IC50 of 47 M It modulates multiple signaling pathways involved in tumorigenesis and inflammation influencing transcription factors growth factors cytokines receptors and enzymes Clinical trials at Phase I reported no observed toxicity at doses up to 12 g/day however oral bioavailability is limited ( 1% in Phase I/II studies) Additionally curcumin demonstrates potential for Alzheimer s research as evidenced by reducing beta-amyloid (A 40 A 42) production via downregulating presenilin-1 and GSK-3 in SH-SY5Y neuroblastoma cells
![Medchemexpress LLC 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile | 116313-73-6 | 98.7% | 231.16 g/mol | C10H5N3O4 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000247968.png-250.jpg)
Medchemexpress LLC 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile | 116313-73-6 | 98.7% | 231.16 g/mol | C10H5N3O4 | 10 MG
Tyrphostin AG 1288 is a small-molecule tyrosine kinase inhibitor used in research to block signaling pathways and reduce inflammatory responses, notably by inhibiting ICAM1 expression and TNFα-mediated cytotoxicity in vitro.
- Potent tyrosine kinase inhibitor.
- Inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro.
- Molecular formula C10H5N3O4; molecular weight 231.16 g/mol.
- Purity 98.7% as supplied.
- Soluble ≥125 mg/mL (≈540.75 mM) in DMSO.
- Appearance solid, light yellow to yellow.
- Recommended storage: powder -20°C up to 3 years or 4°C up to 2 years; in solution -80°C up to 6 months or -20°C up to 1 month.
Medchemexpress LLC Entacapone | 130929-57-6 | MFCD00866580 | 99.2% | 305.29 g/mol | C14H15N3O5 | 5 MG
Entacapone (Standard) is an analytical reference standard of entacapone provided for research and analytical use. Supplied in small quantitative sizes suitable for assay development, method validation, and quality control, the product includes batch documentation and a Certificate of Analysis reporting high purity. It is used as a reference material in studies involving COMT inhibition and related biochemical assays.
- Analytical standard for assay development and method validation.
- Available in small sizes, including a 5 mg vial.
- Certified purity approximately 99.2% (COA available).
- Useful for quality control and reference material applications.
- Molecular formula C14H15N3O5; molecular weight 305.29 g/mol.
Apexbio Technology LLC Tyrphostin AG 1296 146535-11-7 10mM (in 1mL DMSO)
Tyrphostin AG 1296 (CAS 146535-11-7) is a selective inhibitor of platelet-derived growth factor receptor (PDGFR) kinase via ATP-competitive binding Its inhibitory activity (IC50 0 3 0 5 M) results from inducing conformational changes in the ATP-binding domain of PDGFR blocking receptor autophosphorylation induced by ligand binding In vitro studies demonstrate inhibition of PDGF-stimulated mitogenesis (IC50 1 5 M) and cell proliferation (IC50 3 2 M) using Swiss 3T3 cells without significant effects on EGF receptor signaling at concentrations up to 100 M Tyrphostin AG 1296 serves as a research tool for investigating PDGFR-mediated signaling pathways
TARGETMOL CHEMICALS INC POLYINOSINIC-POLYCYTIDYL 25MG
Also available in 5 mg 10 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Polyinosinic-polycytidylic acid (Poly(IC)) is a synthetic double-stranded RNA (dsRNA) analog and is an immunostimulant that acts as the most potent interferon (IFN) inducer. It also is a Toll-like receptor- 3 (TLR3) agonist. purity: 98%
Med Vet International Fluoxetine Capsules (Prozac), 20mg, 100ct
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Fluoxetine is a generic form of PROZac and is an SSRI antidepressant. It affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive disorder.
Apexbio Technology LLC Entacapone 130929-57-6 100mg
Entacapone (CAS 130929-57-6) is a selective second-generation inhibitor of catechol-O-methyltransferase (COMT) It demonstrates potent inhibition of total COMT in mouse liver with reported IC50 and Ki values of 20 1 nM and 10 7 nM respectively In rat models IC50 values for soluble COMT and membrane-bound COMT are 14 3 nM and 73 3 nM Entacapone is primarily utilized in research as an adjunct to levodopa and dopa decarboxylase inhibitor regimens in Parkinson s disease studies given its ability to suppress the formation of 3-O-methyldopa thereby enhancing levodopa bioavailability and prolonging its pharmacological effect
Med Vet International Fluoxetine, 20mg, 30 Tablets
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Fluoxetine is a generic form of PROZac and is an SSRI antidepressant. It affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive disorder.
TARGETMOL CHEMICALS INC I-OME-TYRPHOSTIN AG 538 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4K(alpha) (IC50 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and exhibits preferential cytotoxicity to nutrient-deficient PANC1 cells. purity: 96%