Cinnamic acids and derivatives
TARGETMOL CHEMICALS INC Tipifarnib S enantiomer 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50 0.6 nM). Purity 99.05%
![Medchemexpress LLC Propanedinitrile, 2-[(3,4-dihydroxy-5-nitrophenyl)methylene]- | 116313-73-6 | 98.7% | 231.16 g·mol⁻¹ | C10H5N3O4 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000245870.png-250.jpg)
Medchemexpress LLC Propanedinitrile, 2-[(3,4-dihydroxy-5-nitrophenyl)methylene]- | 116313-73-6 | 98.7% | 231.16 g·mol⁻¹ | C10H5N3O4 | 50 MG
Tyrphostin AG 1288 is a research-grade small-molecule tyrosine kinase inhibitor reported to inhibit ICAM1 expression and TNFα-mediated cytotoxicity in vitro. The compound is supplied with analytical characterization and recommended storage conditions to support reliable laboratory use.
- Potent tyrosine kinase inhibitor in biochemical and cellular assays.
- Inhibits ICAM1 expression in cell-based studies.
- Reduces TNFα-mediated cytotoxicity in vitro.
- High purity suitable for research applications (≈98.7%).
- Available in multiple small pack sizes for laboratory workflows.
- Stable when stored under recommended conditions for powder and solutions.
AdipoGen Curcumin
Chemical. CAS 458-37-7. Formula C21H20O6. MW 368.38. Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, neuroprotective, cardioprotective, antidiabetic, antiviral, antibacterial, antifungal, chemopreventive and antitumor activities. It interferes with multiple cell signaling pathways, including cell cycle cyclin D1 and cyclin E, apoptosis activation of caspases and down-regulation of anti-apoptotic gene products, proliferation HER-2, EGFR and AP-1, survival PI3K/AKT pathway, invasion MMP-9 and adhesion molecules, angiogenesis VEGF, metastasis CXCR-4, tumorigenesis and development Shh, Gli, metabolism PPARgamma, Nrf2, epigenetics HDACs, HATs, DNA methyltransferase I and microRNAs and inflammation NLRP3, TLR4, NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX.
![Medchemexpress LLC Propanedinitrile, 2-[(3,4-dihydroxy-5-nitrophenyl)methylene] | 116313-73-6 | MFCD00236451 | 98.7% | 231.16 g/mol | C10H5N3O4 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000248008.png-250.jpg)
Medchemexpress LLC Propanedinitrile, 2-[(3,4-dihydroxy-5-nitrophenyl)methylene] | 116313-73-6 | MFCD00236451 | 98.7% | 231.16 g/mol | C10H5N3O4 | 5 MG
Tyrphostin AG 1288 is a small-molecule tyrosine kinase inhibitor used in research to modulate signaling pathways. Supplied as a light yellow solid, it inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro and is characterized by formula C10H5N3O4, molecular weight 231.16 g/mol, and typical purity of approximately 98.7%.
- Potent tyrosine kinase inhibition in cellular assays.
- Inhibits ICAM1 expression and TNFα-mediated cytotoxicity.
- High purity suitable for biochemical and cellular studies.
- Available in small milligram-scale packages for laboratory use.
- Solid form with defined appearance for straightforward handling.
Apexbio Technology LLC Tyrphostin AG 1296 146535-11-7 25mg
Tyrphostin AG 1296 (CAS 146535-11-7) is a selective inhibitor of platelet-derived growth factor receptor (PDGFR) kinase via ATP-competitive binding Its inhibitory activity (IC50 0 3 0 5 M) results from inducing conformational changes in the ATP-binding domain of PDGFR blocking receptor autophosphorylation induced by ligand binding In vitro studies demonstrate inhibition of PDGF-stimulated mitogenesis (IC50 1 5 M) and cell proliferation (IC50 3 2 M) using Swiss 3T3 cells without significant effects on EGF receptor signaling at concentrations up to 100 M Tyrphostin AG 1296 serves as a research tool for investigating PDGFR-mediated signaling pathways
Medchemexpress LLC 1,6-heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)- | 458-37-7 | MFCD00008365 | 97.3% | 368.38 g·mol^-1 | C21H20O6 | 10 MG
Curcumin (diferuloylmethane) is a natural phenolic research reagent that functions as a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase. It modulates NF-κB and MAPK pathways, stabilizes Nrf2 through Keap1 cysteine modification, and exhibits anti-inflammatory, antioxidant, antiproliferative, and antiangiogenic activities. Supplied as a characterized powder with recommended storage conditions and a COA.
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.58% | 339.39 | 50 MG
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. It inhibits lipid droplet formation, increases autophagy, and inhibits apoptosis. Furthermore, Curcumin 5-8 improves insulin resistance and insulin sensitivity.
- Potent and orally active naturally active curcumin (CUR) analog.
- Inhibits lipid droplet formation.
- Increases autophagy.
- Inhibits apoptosis.
- Improves insulin resistance and insulin sensitivity.
Medchemexpress LLC Tyrphostin AG1296 | 146535-11-7 | 99.69% | 266.29 | 5 MG
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR) with an IC50 of 0.8 μM. It inhibits the signaling of human PDGF α- and β-receptors, the related stem cell factor receptor (c-Kit), and FLT3.
- Potent and selective inhibitor of PDGFR with an IC50 of 0.8 μM.
- Inhibits signaling of human PDGF α- and β-receptors.
- Inhibits the related stem cell factor receptor (c-Kit).
- Potent inhibitor of FLT3 in the micromolar range.
- Suppresses viability of PLX4032-resistant melanoma cells.
- Induces apoptosis of A375R cells.
- Inhibits PDGFR phosphorylation.
- Inhibits migration of A375R cells.
- Suppresses tumor growth in mice models.
- Inhibits atherosclerotic plaque progression and enhances plaque stability.
Medchemexpress LLC (3Z)-2-amino-4-(4-hydroxyphenyl)buta-1,3-diene-1,1,3-tricarbonitrile | 144978-82-5 | 98.6% | 236.23 g/mol | C13H8N4O | 5 MG
Tyrphostin AG 112 is a small-molecule inhibitor of epidermal growth factor receptor (EGFR) phosphorylation used in biochemical and cellular research. The compound is supplied as a solid with high purity and is compatible with DMSO-based solutions for in vitro testing and with co-solvent formulations for in vivo studies.
- Molecular formula: C13H8N4O.
- Molecular weight: 236.23 g/mol.
- Purity: 98.6%.
- Appearance: solid.
- Solubility: DMSO soluble (125 mg/mL); in vivo co-solvent formulations give clear solutions.
- Available pack sizes: 5 mg, 10 mg, 25 mg, larger sizes by quote.
Medchemexpress LLC 4-Hydroxybenzylidenemalononitrile | 3785-90-8 | MFCD00020189 | 98.0% | 170.17 g/mol | C10H6N2O | 25 MG
Tyrphostin 8 (4-hydroxybenzylidenemalononitrile, CAS 3785-90-8) is a small-molecule tyrosine kinase inhibitor reported to target EGFR, with additional activity against GTPases and the serine/threonine phosphatase calcineurin. Provided for research use in solid and DMSO solution formats, it has molecular formula C10H6N2O, molecular weight 170.17 g/mol, and listed purity 98.0%.
- Reported EGFR inhibitor (IC50 = 560 μM).
- Inhibits calcineurin phosphatase activity (IC50 = 21 μM).
- Also reported to inhibit GTPase activity.
- Supplied as solid and as 10 mM solution in DMSO for assay flexibility.
- Listed purity 98.0% suitable for biochemical research.
- Chemical formula C10H6N2O; molecular weight 170.17 g/mol.
Medchemexpress LLC (2E,4E)-hexa-2,4-dien-1-ol | 17102-64-6 | MFCD00002925 | 98.8% | 98.14 g/mol | C6H10O | 1 G
(2E,4E)-Hexa-2,4-dien-1-ol is a small organic compound containing a conjugated diene and a primary alcohol. It is used as a biochemical assay reagent and reference standard in chemical research and flavor/aroma studies. Supplied for research use only.
- High purity (98.81%).
- Molecular formula C6H10O; molecular weight 98.14 g/mol.
- DMSO soluble (200 mg/mL); ultrasonic recommended.
- Appearance: colorless to light yellow; solid below ~28°C, liquid above ~33°C.
- Long-term storage stability: pure form -20°C for up to 3 years.
- COA and SDS available for quality and safety information.
TARGETMOL CHEMICALS INC BISDEMETHOXYCURCUMIN 50MG
Also available in 5 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis interacting with 1(alpha) 25-dihydroxy vitamin D3 to stimulate amyloid-(beta) clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300 suppressing the Wnt/(beta)-catenin pathway and inhibits LPS induction of iNOS expression [3]. purity: 99%
Selleck Chemical LLC Bisdemethoxycurcumin (BDMC) S3938-25mg
Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin and possesses several biological activities such as anti-inflammation and anti-cancer activities