Cinnamic acids and derivatives
![Medchemexpress LLC 2-propenamide, N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-, (2E)- | 456-12-2 | MFCD00048045 | 99.8% | 297.35 | C18H19NO3 | 10 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000209224.png-250.jpg)
Medchemexpress LLC 2-propenamide, N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-, (2E)- | 456-12-2 | MFCD00048045 | 99.8% | 297.35 | C18H19NO3 | 10 G
Aegeline is a high-purity natural alkaloid reference standard intended for analytical and pharmacological research. It is supplied as a solid and is also available as a DMSO solution for analytical use and method development.
- Purity 99.81%
- Cas number 456-12-2
- Molecular formula C18H19NO3
- Molecular weight 297.35 g/mol
- Physical form Solid and DMSO solution
- Typical applications Analytical standards, method development, and pharmacological research
- Available package sizes 500 mg, 1 g, 5 g, 10 g, and 50 g (quote)
- Product documents Data sheet and certificate of analysis available as PDF
![eMolecules N-(1-[4-(dimethylamino)phenyl]-3-{2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylidene]hydrazinyl}-3-oxoprop-1-en-2-yl)benzamide | ChemDiv SC |584.414 | C26H25IN4O4COc1cc(\C=N\NC(=O)C(\NC(=O)c2ccccc2)=C/c2ccc(cc2)N(C)C)cc(I)c1O | 2mg | 828451810](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC3733135.jpg-250.jpg)
eMolecules N-(1-[4-(dimethylamino)phenyl]-3-{2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylidene]hydrazinyl}-3-oxoprop-1-en-2-yl)benzamide | ChemDiv SC |584.414 | C26H25IN4O4COc1cc(\C=N\NC(=O)C(\NC(=O)c2ccccc2)=C/c2ccc(cc2)N(C)C)cc(I)c1O | 2mg | 828451810
N-(1-[4-(dimethylamino)phenyl]-3-{2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylidene]hydrazinyl}-3-oxoprop-1-en-2-yl)benzamide | ChemDiv SC |584.414 | C26H25IN4O4COc1cc(\C=N\NC(=O)C(\NC(=O)c2ccccc2)=C/c2ccc(cc2)N(C)C)cc(I)c1O | 2mg | 828451810
eMolecules 2699937-04-5 | Medchem Express | MRL-494 (hydrochloride) | 5mg | 552386588 | HY-128773A | 659.13 | C26H36ClFN16O2
Medchem Express | Apramycin (sulfate) | 100mg | 446273816 | HY-B1329 | 65710-07-8 | 637.660 | C21H43N5O15S
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Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 10 MG
Tyrphostin A1 (AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It is for research use only.
- Inhibits CD40L-stimulated IL-12 production in macrophage cultures
- Decreases IL-12 p40 production in a dose-dependent manner
- Blocks CD40L-induced translocation of NF-κB to the nucleus
- Reduces activation of IL-12 p40 gene
- Leads to a decrease in the generation of myelin basic protein (MBP) specific encephalitogenic T cells in vivo therapy
- Attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice
- Weaker inhibitor of TK compared to other tyrphostins, useful for differentiating TK-mediated effects
Apexbio Technology LLC Entacapone 130929-57-6 10mg
Entacapone (CAS 130929-57-6) is a selective second-generation inhibitor of catechol-O-methyltransferase (COMT) It demonstrates potent inhibition of total COMT in mouse liver with reported IC50 and Ki values of 20 1 nM and 10 7 nM respectively In rat models IC50 values for soluble COMT and membrane-bound COMT are 14 3 nM and 73 3 nM Entacapone is primarily utilized in research as an adjunct to levodopa and dopa decarboxylase inhibitor regimens in Parkinson s disease studies given its ability to suppress the formation of 3-O-methyldopa thereby enhancing levodopa bioavailability and prolonging its pharmacological effect
Sigma Aldrich Fine Chemicals Biosciences Curcumin from Curcuma long50G
Curcumin from Curcuma long50G
Cayman Chemical Curcumin, Purity: ≥90%, CAS: 458-37-7, 100 g
A yellow pigment with diverse biological activities; inhibits NO production (IC50 = 6 μM) and reduces iNOS activity in LPS-stimulated RAW 264.7 cells; inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells; decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis; prevents ovalbumin-induced accumulation of 3-NT in mouse heart; reduces TPA-induced tumor formation in mouse skin (1-10 μmol); reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-NQO in rats
Medchemexpress LLC Entacapone | 130929-57-6 | 99.97% | C14H15N3O5 | 50 MG
Entacapone is a potent, reversible, peripherally acting, and orally active catechol-O-methyltransferase (COMT) inhibitor. It is selective for COMT over other catecholamine metabolizing enzymes and can be used for Parkinson's disease research. Entacapone also inhibits FTO demethylation, making it relevant for metabolic disorders research.
- Inhibits COMT with IC50 values in the nanomolar range
- Demonstrates agonist activity at GPR35 in HT-29 and U2OS cells
- Enhances m6A on mRNA in Hep-G2 cells
- Decreases body weight and fat mass in obese mouse models
- Reduces total cholesterol, low-density lipoprotein cholesterol, and triglycerides
Sigma Aldrich Fine Chemicals Biosciences Curcumin from Curcuma longa (Turmeric), powder | 458-37-7 | MFCD00008365 | 10g
Curcumin from Curcuma longa (Turmeric), powder | Purity: 65% | 368.38 | 458-37-7 | MFCD00008365 | 10g
Cayman Chemical Curcumin, Purity: ≥90%, CAS: 458-37-7, 5 g
A yellow pigment with diverse biological activities; inhibits NO production (IC50 = 6 μM) and reduces iNOS activity in LPS-stimulated RAW 264.7 cells; inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells; decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis; prevents ovalbumin-induced accumulation of 3-NT in mouse heart; reduces TPA-induced tumor formation in mouse skin (1-10 μmol); reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-NQO in rats
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 50 MG
Tyrphostin A1 (AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It blocks CD40L-induced translocation of NF-κB to the nucleus and reduces the activation of the IL-12 p40 gene. In vivo therapy with A1 leads to a decrease in the generation of myelin basic protein (MBP) specific encephalitogenic T cells and attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice.
- Target: IL-12 production inhibitor
- Dose-dependent decrease of IL-12 p40, with maximal inhibition (62.5%) occurring at a dose of 10 μM
- Significantly weaker inhibitor of TK than other tyrphostins (IC50>1250 μM for epidermal growth factor receptor (EGFR) kinase)
- Useful for differentiating TK-mediated effects of tyrphostins from other non-specific effects