Cinnamic acids and derivatives
Medchemexpress LLC Ozagrel hydrochloride | 78712-43-3 | MFCD06795644 | >98.0% | 10 MG
Ozagrel hydrochloride is the hydrochloride salt of ozagrel, a selective thromboxane A2 (TXA2) synthase inhibitor used in preclinical research to study platelet aggregation, ischemic stroke, asthma, and thromboembolic disease.
- Selective thromboxane A2 (TXA2) synthase inhibitor with reported IC50 ~11 nM.
- Reduces thromboxane A2 production, leading to anti-platelet aggregation and vasodilation.
- Hydrochloride salt supplied as a powder suitable for in vitro and in vivo research.
- Typical molecular weight 264.71 g/mol and formula C13H13ClN2O2.
- High purity commonly reported as ≥98% (verify with vendor for specific lot).
- Store powder at -20°C for long-term stability; in solution, store at -80°C.
Medchemexpress LLC Ferulic acid acyl-β-D-glucoside | 7196-71-6 | 1 ML
Ferulic acid acyl-β-D-glucoside is a metabolite of Ferulic Acid that can be isolated from flaxseed extract. It is identified as a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor and is intended for research use only.
- Metabolite of Ferulic Acid
- Can be isolated from flaxseed extract
- Inhibits fibroblast growth factor receptor 1 (FGFR1) and FGFR2
- Purity: 99.33%
- Appearance: White to off-white solid
- Soluble in water (50 mg/mL)
- Soluble in PBS (25 mg/mL)
- Initial source from plants (Rosaceae, Aruncus sylvester Kostel.)
Medchemexpress LLC p-Hydroxycinnamic acid | 7400-08-0 | 25 G
p-Hydroxycinnamic acid is a common dietary phenol known for its ability to inhibit platelet activity. It is also recognized as a ubiquitous plant metabolite possessing antioxidant and anti-inflammatory properties. This compound interferes with the arachidonic acid cascade, leading to reduced thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation.
- Inhibits platelet activity
- Reduces ADP-induced platelet aggregation
- White to off-white solid appearance
- Purity of 99.94%
- Molecular weight: 164.16
- Formula: C9H8O3
- Target: Endogenous metabolite, prostaglandin receptor
- Soluble in DMSO (>= 100 mg/mL) and ethanol (33.33 mg/mL)
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 10 MG
Tyrphostin A1 (AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It is for research use only.
- Inhibits CD40L-stimulated IL-12 production in macrophage cultures
- Decreases IL-12 p40 production in a dose-dependent manner
- Blocks CD40L-induced translocation of NF-κB to the nucleus
- Reduces activation of IL-12 p40 gene
- Leads to a decrease in the generation of myelin basic protein (MBP) specific encephalitogenic T cells in vivo therapy
- Attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice
- Weaker inhibitor of TK compared to other tyrphostins, useful for differentiating TK-mediated effects
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 50 MG
Tyrphostin A1 (AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It blocks CD40L-induced translocation of NF-κB to the nucleus and reduces the activation of the IL-12 p40 gene. In vivo therapy with A1 leads to a decrease in the generation of myelin basic protein (MBP) specific encephalitogenic T cells and attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice.
- Target: IL-12 production inhibitor
- Dose-dependent decrease of IL-12 p40, with maximal inhibition (62.5%) occurring at a dose of 10 μM
- Significantly weaker inhibitor of TK than other tyrphostins (IC50>1250 μM for epidermal growth factor receptor (EGFR) kinase)
- Useful for differentiating TK-mediated effects of tyrphostins from other non-specific effects
Medchemexpress LLC (E)-Ferulic acid | 537-98-4 | 99.9% | 194.19 | 1 ML
(E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound found in plant cell walls. It causes phosphorylation of β-catenin, leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax, and reducing the expression of the survival factor survivin. It can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation, and exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.
- Removes reactive oxygen species (ROS)
- Inhibits lipid peroxidation
- Exerts antiproliferative effects in human lung cancer cells
- Exerts antimigratory effects in human lung cancer cells
- Induces phosphorylation and proteasome degradation of β-catenin
- Increases expression of pro-apoptotic factor Bax
- Reduces expression of the survival factor survivin
- Reduces liver and kidney toxicity and oxidative stress
Medchemexpress LLC Cinnamic acid | 621-82-9 | MFCD00004369 | 148.16 | 1 G
Cinnamic acid has potential use in cancer intervention, exhibiting IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate, and lung carcinoma cells. In addition to inhibiting tumor-cell proliferation, Cinnamic acid induces morphological changes consistent with melanocyte differentiation. Treatment with Cinnamic acid also leads to a dose-dependent loss of invasive capacity in various tumor lines.
- Endogenous metabolite
- Potential use in cancer intervention
- Exhibits dose-dependent growth inhibition in various tumor cells
- Induces morphological changes consistent with melanocyte differentiation
- Causes dose-dependent loss of invasive capacity in tumor lines
- Purity: 99.98%
- Appearance: Solid
- Color: White to off-white
- Initial source: Microorganisms
- Storage: powder at -20°C for 3 years, 4°C for 2 years; in solvent at -80°C for 2 years, -20°C for 1 year