Coumarins and derivatives
Apexbio Technology LLC HX 531 188844-34-0 10mg
HX 531 (CAS 188844-34-0) is a small-molecule antagonist targeting the retinoid X receptor (RXR) It modulates RXR-associated signaling pathways thereby influencing both tumorigenic and metabolic biological processes HX 531 exerts its biological activity by antagonizing RXR which results in cell cycle arrest at the G0/G1 phase and modulation of leptin-dependent pathways and the p53-p21Cip1 signaling axis In rodent models HX 531 demonstrates an inhibitory activity with an IC50 value of approximately 18 nM Based on these pharmacological properties HX 531 holds research potential in the study of metabolic disorders obesity diabetes and cancer biology
Medchemexpress LLC Coumarin-C2-TCO | 2488174-16-7 | >98.0% | 455.55 | C25H33N3O5 | 10 MG
Coumarin-C2-TCO is a coumarin-derived fluorescent dye functionalized with a trans-cyclooctene (TCO) reactive handle that undergoes rapid inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine-bearing molecules for bioorthogonal labeling and conjugation.
- Fluorescent coumarin core provides a dye scaffold for imaging and detection.
- TCO reactive handle enables fast, bioorthogonal iEDDA conjugation to tetrazines.
- Suitable for labeling biomolecules and developing fluorescent probes in chemical biology workflows.
- Offered in small research quantities for synthesis and assay development.
Medchemexpress LLC 7-methoxycoumarin-3-carboxylic acid | 20300-59-8 | MFCD00452770 | ≥97.0% | 220.18 | C11H8O5 | 1 G
7-Methoxycoumarin-3-carboxylic acid is a coumarin-derived fluorescent dye used to label peptides and other biomolecules for biochemical assays and HPLC derivatization. It is supplied as a solid with high purity and is prepared as a DMSO stock for use in fluorescence-based assays; handle and store protected from light.
- Excitation and emission in the near-UV/blue range (Ex ≈345-355 nm, Em ≈405-450 nm).
- Suitable for peptide labeling and HPLC derivatization.
- High purity appropriate for analytical applications (~97.0%).
- Soluble in DMSO (≈8 mg/mL with sonication and warming).
- Store protected from light; in solution, keep frozen for extended stability.
![Medchemexpress LLC Methanesulfonamide, N-[2-chloro-5-[4-[[(1R)-1-phenylethyl]amino]-6-quinazolinyl]-3-pyridinyl]- | 2791417-66-6 | 99.9% | 453.94 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000395426.png-250.jpg)
Medchemexpress LLC Methanesulfonamide, N-[2-chloro-5-[4-[[(1R)-1-phenylethyl]amino]-6-quinazolinyl]-3-pyridinyl]- | 2791417-66-6 | 99.9% | 453.94 | 25 MG
MTX-531 is an oral drug that inhibits EGFR and PI3K, demonstrating anti-tumor effects. It also acts as a weak agonist of PPARγ, helping to alleviate hyperglycemia induced by PI3K inhibitors. This compound shows good tolerability in in vivo studies, without causing hyperglycemia, a common side effect of PI3K inhibitors.
- Inhibits EGFR with an IC50 of 14.7 nM, and PI3K with IC50 values ranging from 1.1 nM to 233 nM.
- Demonstrates anti-tumor effects, suppressing tumor proliferation and growth.
- Acts as a weak agonist of PPARγ with an IC50 of 2.5 μM, which helps to alleviate hyperglycemia.
- Indicates excellent tolerance in mice and the absence of hyperglycemia in vivo.
Apexbio Technology LLC 3-Nitrocoumarin 28448-04-6 5mg
3-Nitrocoumarin (CAS 28448-04-6) is a selective inhibitor of phospholipase C- (PLC- ) an enzyme involved in cellular signal transduction through the hydrolysis of membrane phospholipids and subsequent generation of secondary messengers By suppressing PLC- catalytic activity 3-Nitrocoumarin disrupts related intracellular signaling pathways thereby enabling investigation of PLC- -mediated mechanisms in various physiological and pathological contexts This compound is widely utilized in studies focused on elucidating the roles of PLC- in disease models and fundamental biomedical research
Medchemexpress LLC HY-111919 10mg Medchemexpress, 3-Nitrocoumarin CAS:28448-04-6 Purity:>98%
Medchemexpress, HY-111919 10mg 3-Nitrocoumarin CAS:28448-04-6 3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLC-γ) inhibitor. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical 4-HydroxycoumarIn 250g
A coumarin; inhibits vitamin K1 epoxidation and prothrombin synthesis by 18 and 67%, respectively, in cell-free assays at 6.2 mM; has been used in the synthesis of anticoagulants, as well as antithrombotic, anti-inflammatory, antibacterial, and antifungal agents
Medchemexpress LLC 7-Methylcoumarin | 2445-83-2 | MFCD00006880 | 25 G
7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. It acts as a mechanism-based inhibitor for CYP2A6, significantly decreasing ALT, AST, and serum bilirubin in rats with CCl4-induced liver damage. It also restores total protein and albumin levels in serum while preventing oxidative stress, and can decline mitotic activity of *A. sativum* promeristem.
- Coumarin derivative
- Potent hepatoprotective and antioxidant properties
- Mechanism-based inhibitor for CYP2A6
- Decreases ALT, AST, and serum bilirubin in rats with CCl4-induced liver damage
- Restores total protein and albumin levels in serum
- Prevents oxidative stress
- Can decline mitotic activity of *A. sativum* promeristem
- Purity: 99.34%
- Appearance: Solid, white to off-white