Flavonoids
Medchemexpress LLC 4'-Methoxyflavone | 4143-74-2 | 99.63% | 252.26 | 25 MG
4'-Methoxyflavone is a flavonoid with antioxidant properties and anti-proliferative activity against cancer cells. It can inhibit cycle-dependent kinases, leading to cell cycle arrest, and regulate cell signaling pathways to influence cell proliferation and apoptosis. This compound can be used in cancer chemoprevention research.
- Flavonoid with antioxidant properties
- Anti-proliferative activity against cancer cells
- Inhibits cycle-dependent kinases
- Leads to cell cycle arrest
- Regulates cell signaling pathways to influence cell proliferation and apoptosis
- Used in cancer chemoprevention research
Medchemexpress LLC AMG 487 | 473719-41-4 | C32H28F3N5O4 | 100 MG
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3). It inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
- Targets CXCR3
- Involved in GPCR/G Protein and immunology/inflammation pathways
- Inhibits CXCR3-mediated cell migration
- Inhibits calcium mobilization
- Leads to fewer lung metastases
- Reduces tumor volume
Medchemexpress LLC (-)-Catechin | 18829-70-4 | 290.27 | 100 MG
(-)-Catechin is a form of catechin that inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. It promotes the differentiation of human bone marrow mesenchymal stem cells (hBM-MSC) into adipose cells, leading to increased fat cell differentiation and higher levels of PPARγ. This compound is intended for research use only.
- Inhibits cyclooxygenase-1 (COX-1).
- Promotes hBM-MSC adipose cell differentiation.
- Increases fat cell differentiation.
- Elevates PPARγ levels.
Medchemexpress LLC (-)-Catechin | 18829-70-4 | 290.27 | 1 ML
(-)-Catechin is a structural isomer of Catechin. It inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. Additionally, (-)-Catechin promotes the differentiation of hBM-MSC adipose cells, leading to increased fat cell differentiation and PPARγ levels. It is intended for research use only.
- Inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
- Promotes adipocyte differentiation in human bone marrow mesenchymal stem cells (hBM-MSC).
- Increases fat cell differentiation.
- Increases PPARγ level.
Medchemexpress LLC Luteolin-7-rutinoside | 20633-84-5 | 5 MG
Luteolin-7-rutinoside possesses both anti-arthritic and antifungal activities, which can lead to a combination therapy for treating fungal arthritis caused by *C. albicans* infection. It is intended for research use only and not for sale to patients.
- Possesses anti-arthritic activity.
- Possesses antifungal activity.
- Reduces proliferation of T cells in a dose-dependent manner.
- Shifts Th1-Th2 balance away from Th1 towards Th2-type responses.
- Inhibits nitric oxide (NO) production from macrophages.
Medchemexpress LLC Catechin | 154-23-4 | 290.27 | 100 MG
Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
- Mechanism of action: inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM and exhibits >95% inhibitory activity at 70 μg/mL against COX-1.
- Cellular effects: induces apoptosis in MCF-7 cells in a dose- and time-dependent manner, leading to increased expression levels of Caspase-3, -8, -9, and p53.
- In vivo effects: prevents time-induced episodic memory deficits in animals in a dose-dependent manner (most effective at 200 mg/kg, p.o.) and prevents the rise in MPO level.
Apexbio Technology LLC AST 487 630124-46-8 10mg
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Apexbio Technology LLC AST 487 630124-46-8 5mg
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Apexbio Technology LLC AST 487 630124-46-8 50mg
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Apexbio Technology LLC AST 487 630124-46-8 10mM (in 1mL DMSO)
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Medchemexpress LLC Myricetin | 529-44-2 | C15H10O8 | 100 MG
Myricetin is a common plant-derived flavonoid known for a wide range of activities, including strong antioxidant, anticancer, antidiabetic, and anti-inflammatory properties. It is intended for research use only.
- Exhibits scavenging activity towards radicals and ions
- Prevents cancer cell death via apoptosis by regulating PI3K/Akt and MAPK signaling pathways
- Displays antiphotoaging effects by quenching causative free radicals in the skin
- Suppresses UVB-induced COX-2 expression
- Inhibits viability of SKOV3 ovarian cancer cells in a dose-dependent manner
- Induces DNA DSBs and ER stress, leading to apoptosis
- Inhibits human Hsp70 by over 80%
Sigma Aldrich Fine Chemicals Biosciences Luteolin 98 TLC powder50MG
Luteolin (3AE 4AE 5AE 7AE-tetrahydroxyflavone) a polyphenolic compound belongs to flavones subclass of flavonoids. Luteolin is commonly found in plants like celery green peppers and chamomile tea. Luteolin is one of the major flavonoids present in the flower extract of Hieracium pannosum Boiss aerial part of Dracocephalum kotschyi and contributes to the antioxidant potential of the plant. Luteolin possesses antioxidant anti-inflammatory properties and exerts anti-tumor potential primarily through apoptosis. Luteolin exerts its apoptotic activity through downregulation of protein kinase B (Akt) pathway leading to caspase mediated apoptosis. Luteolin also resensitizes cancer cells to therapeutics. Luteolin regulates the inflammatory genes and reduces nitric oxide and inflammatory cytokine production. The anti-inflammatory property of luteolin implicates it as a potential therapeutic agent for the neurodegenerative disease like Alzheimer disease. In plants luteolin induces nodu
Medchemexpress LLC Myricetin | 529-44-2 | C15H10O8 | 25 MG
Myricetin is a plant-derived flavonoid with strong antioxidant, anticancer, antidiabetic, and anti-inflammatory properties. It exhibits scavenging activity against radicals and ions, prevents cancer cell death via apoptosis through PI3K/Akt and MAPK signaling, and shows antiphotoaging effects by quenching free radicals in the skin. It also inhibits ovarian cancer cell viability and human Hsp70.
- Strong antioxidant, anticancer, antidiabetic, and anti-inflammatory activities
- Scavenges various radicals and ions
- Prevents cancer cell death via apoptosis
- Exhibits antiphotoaging effects in skin
- Suppresses UVB-induced COX-2 expression
- Inhibits UVB-induced initiation of activator protein-1 and NF-κβ
- Inhibits Fyn kinase activity
- Inhibits viability of SKOV3 ovarian cancer cells
- Induces DNA DSBs and ER stress leading to apoptosis
- Inhibits human Hsp70