Isoflavonoids
Cayman Chemical SophorIcosIde 500mg
An isoflavone glycoside with diverse biological activities; inhibits oleic acid-induced lipid accumulation in HepG2 cells and stimulates glucose uptake in C2C12 mouse skeletal muscle myoblasts at 10 µM; inhibits compound 48/80- or histamine-induced scratching behavior in mice at 2 mg/kg; reduces serum levels of IgE in a mouse model of atopic dermatitis; increases serum levels of osteocalcin and ALP and restores mechanical bone hardness in an ovariectomized rat model of osteoporosis; decreases hepatic cholesterol and triglyceride levels, serum LDL and apolipoprotein B levels, and hepatic injury in a mouse model of fructose-induced liver injury at 80 and 160 mg/kg
Apexbio Technology LLC Daidzein 486-66-8 10mM (in 1mL DMSO)
Daidzein is an isoflavone compound derived from soybeans structurally classified as a phytoestrogen with structural similarity to endogenous estrogen It has been widely investigated for its potential in biomedical research particularly in oncology and cell biology studies Daidzein exhibits anticancer-related biological activity possibly via modulation of hormonal signaling pathways and interference with cell cycle progression as exemplified by inducing cell cycle arrest at the G1 phase in cultured mammalian cells Additionally it demonstrates antioxidant properties providing protective effects against oxidative stress-mediated cell injury such as hepatic cellular damage induced by chemical carcinogens Daidzein is thus employed in studies focused on hormone-dependent tumorigenesis cell-cycle regulation mechanisms and oxidative-stress-induced cellular responses
Medchemexpress LLC 5-Methyl-7-methoxyisoflavone | 82517-12-2 | 266.29 | 50 MG
5-Methyl-7-methoxyisoflavone is an orally active anti-oxidant with remyelinating activity. It inhibits the enzyme aromatase and acts as a non-steroidal anabolic isoflavone, demonstrating better potency in increasing muscle mass and endurance than Ipriflavone. It is also an inhibitor for NF-κB and can be used for fat loss, maintaining low cholesterol levels, and strengthening bones.
- Orally active anti-oxidant
- Inhibits aromatase enzyme
- Non-steroidal anabolic isoflavone
- Increases muscle mass and endurance
- Supports fat loss
- Helps maintain low cholesterol levels
- Strengthens bones
- Inhibits NF-κB
Apexbio Technology LLC Genistein(Synonyms: 4',5,7-Trihydroxyisoflavone, Genisteol, Prunetol, Sophoricol, Differenol A), 100mg, CAS: 446-72-0.
Genistein (CAS 446-72-0) is an isoflavonoid compound that selectively inhibits protein tyrosine kinases enzymes implicated in signaling pathways associated with oncogenic activity and cellular proliferation Genistein inhibits tyrosine kinase activity with an IC50 of approximately 8 M In NIH-3T3 cell assays genistein suppresses epidermal growth factor (EGF)-mediated mitogenesis (IC50 12 M) and insulin-mediated effects (IC50 19 M) additionally inhibiting EGF-induced activation of S6 kinase at a concentration of 6 15 M In animal models oral administration of genistein demonstrates dose-dependent inhibition of prostate adenocarcinoma development highlighting its utility in cancer biology research and potential chemopreventive applications
Apexbio Technology LLC Genistein(Synonyms: 4',5,7-Trihydroxyisoflavone, Genisteol, Prunetol, Sophoricol, Differenol A), 10mM (in 1mL DMSO), CAS: 446-72-0.
Genistein (CAS 446-72-0) is an isoflavonoid compound that selectively inhibits protein tyrosine kinases enzymes implicated in signaling pathways associated with oncogenic activity and cellular proliferation Genistein inhibits tyrosine kinase activity with an IC50 of approximately 8 M In NIH-3T3 cell assays genistein suppresses epidermal growth factor (EGF)-mediated mitogenesis (IC50 12 M) and insulin-mediated effects (IC50 19 M) additionally inhibiting EGF-induced activation of S6 kinase at a concentration of 6 15 M In animal models oral administration of genistein demonstrates dose-dependent inhibition of prostate adenocarcinoma development highlighting its utility in cancer biology research and potential chemopreventive applications
Cayman Chemical SophorIcosIde 250mg
An isoflavone glycoside with diverse biological activities; inhibits oleic acid-induced lipid accumulation in HepG2 cells and stimulates glucose uptake in C2C12 mouse skeletal muscle myoblasts at 10 µM; inhibits compound 48/80- or histamine-induced scratching behavior in mice at 2 mg/kg; reduces serum levels of IgE in a mouse model of atopic dermatitis; increases serum levels of osteocalcin and ALP and restores mechanical bone hardness in an ovariectomized rat model of osteoporosis; decreases hepatic cholesterol and triglyceride levels, serum LDL and apolipoprotein B levels, and hepatic injury in a mouse model of fructose-induced liver injury at 80 and 160 mg/kg
AdipoGen Formononetin
Chemical. CAS 485-72-3. Formula C16H12O4. MW 268.26. Formononetin is an isoflavonoid phytoestrogenic compound found in soy-based foods and is the precursor of daidzein. It acts as an agonist of the aryl hydrocarbon receptor and a selective inhibitor of ADH gamma the gamma-isoform of alcohol dehydrogenase. It displays potent antitumor, antiviral, anti-inflammatory inhibits NLRP3 inflammasome, antioxidant, neuroprotective and neuroinflammatory properties. Also shown to have vasorelaxant, antihypertensive and antihyperglycemic AMPK activator properties. Induces cell cycle arrest and apoptosis in several cancer cells in vitro and in vivo and shows anti-angiogenic FGFR2 inhibitor, anti-invasive and anti-migratory effects. Increases adipocyte thermogenesis by modulating PPARgamma activity.
AdipoGen Genistein
Chemical. CAS 446-72-0. Formula C15H10O5. MW 270.24. Genistein is an isoflavonoid phytoestrogen that has been found in soybeans and has kinase inhibitory, anticancer, pro-cancer and hepatoprotective properties. It is a cell-permeable, reversible, substrate competitive tyrosine kinase inhibitor including EGFR phosphorylation, implicated in almost all cell growth and proliferation signal cascades. Genistein inhibits proliferation and induces cell cycle arrest and apoptosis in a variety of cancer cells. It is antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis. On a molecular level it also inhibits mammalian DNA topoisomerase II and DNA methyltransferase, and binds to estrogen receptor beta. Genistein has also antidiabetic, anti-inflammatory, antimicrobial and antioxidant properties.
Medchemexpress LLC Genistein (Standard) | 446-72-0 | MFCD00016952 | 98.7% | C₁₅H₁₀O₅ | 50 MG
Genistein (Standard) is an analytical standard and soy isoflavone. It acts as a multiple tyrosine kinases inhibitor, used in chemotherapeutic research to alter apoptosis, cell cycle, angiogenesis, and inhibit metastasis. This product is intended for research and analytical applications.
- Reference standard for assay
- Used in qualitative research
- Used in quantitative research
- Used in methodological research experiments
- Compatible with HPLC, GC, and MS
TARGETMOL CHEMICALS INC ONONIN 20MG
Also available in 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Ononin (Formononetin 7-O-glucoside) can inhibit the growth of pathogen. 2. Ononin plays an important role in human nutrition as health promoting natural chemicals and are established to be the beneficial components. purity: 99%
Cayman Chemical Formononetin 10mg
An isoflavonoid phytoestrogenic compound found in soy-based foods; acts as an agonist of the aryl hydrocarbon receptor (EC50 = 0.13 µM) and has been reported to possess antitumor and antiviral activity
Cayman Chemical SophorIcosIde 100mg
An isoflavone glycoside with diverse biological activities; inhibits oleic acid-induced lipid accumulation in HepG2 cells and stimulates glucose uptake in C2C12 mouse skeletal muscle myoblasts at 10 µM; inhibits compound 48/80- or histamine-induced scratching behavior in mice at 2 mg/kg; reduces serum levels of IgE in a mouse model of atopic dermatitis; increases serum levels of osteocalcin and ALP and restores mechanical bone hardness in an ovariectomized rat model of osteoporosis; decreases hepatic cholesterol and triglyceride levels, serum LDL and apolipoprotein B levels, and hepatic injury in a mouse model of fructose-induced liver injury at 80 and 160 mg/kg
Medchemexpress LLC Formononetin | 485-72-3 | 98.79% | 268.26 | 5 MG
Formononetin (Standard) is the analytical standard of Formononetin, intended for research and analytical applications. It is a potent FGFR2 inhibitor that potently inhibits angiogenesis and tumor growth. The compound is of analytical standard grade, used as a reference standard in qualitative, quantitative, and methodological research experiments.
- Analytical standard of Formononetin
- Potent FGFR2 inhibitor with an IC50 of ~4.31 μM
- Potently inhibits angiogenesis and tumor growth
- Commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS