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Biochanin A (CAS number 491-80-5) is a naturally derived inhibitor of fatty acid amide hydrolase (FAAH) an enzyme responsible for metabolizing the endocannabinoid anandamide (AEA) In vitro studies show Biochanin A inhibits FAAH-mediated hydrolysis of AEA with IC50 values of 1 8 M (mouse) 1 4 M (rat) and 2 4 M (human) without affecting CB1 CB2 receptors or FAAH-2 In animal models Biochanin A attenuates formalin-induced phosphorylation of spinal extracellular signal-regulated kinase an effect reversible by CB1 receptor antagonist AM251 Biochanin A thus serves as a useful tool compound in pain regulation and endocannabinoid research
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Daidzin (Daidzoside Daidzein 7-O-glucoside Daidzein 7-glucoside) a natural organic compound in the class of phytochemicals known as isoflavones is a potent and selective inhibitor of human mitochondrial aldehyde dehydrogenase and inhibits ALDH-I selectively (Ki 20 nM) at least 500 times less effective against ALDH- the cytosolic isozyme (Ki 10 M)
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Flavone (2-Phenylchromone 2-Phenyl-4-chromone 2-Phenyl-4-benzopyron) a class of flavonoids mainly found in spices and red or purple plant foods with antioxidant anti-proliferative anti-tumor anti-microbial estrogenic acetyl cholinesterase anti-inflammatory activities and are also used in cancer cardiovascular disease neurodegenerative disorders etc
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An isoflavonoid with antioxidant activity; scavenges peroxynitrite, nitric oxide radicals, and total ROS (IC50s = 1.36, 1.13, and 6.51 µM, respectively)
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