Linear 1 3-diarylpropanoids
Medchemexpress LLC Dibenzoylmethane | 120-46-7 | MFCD00003085 | 98.0% | 224.26 | 25 G
Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. It is an analog of curcumin and results in dissociation from Keap1 and nuclear translocation of Nrf2. It is for research use only and not sold to patients.
- Activates Nrf2.
- Helps prevent various cancers and oxidative damage.
- Functions as an analog of curcumin.
- Leads to dissociation of Keap1 and nuclear translocation of Nrf2.
- Available in solid form, off-white to light yellow in color.
- Suitable for in vitro and in vivo studies.
- Stable for 3 years when stored as a solid at room temperature.
Selleck Chemical LLC 4-Hydroxychalcone S4937-100mg
4 -Hydroxychalcone (P-Cinnamoylphenol) found in herbs and spices and tea is a member of the class of compounds known as retrochalcones It has diverse biological activities inhibiting TNF -induced NF- B pathway activation in a dose-dependent manner and activating BMP signaling
Apexbio Technology LLC 4-METHOXYCHALCONE 1-5000mg
4-Methoxychalcone-1 (CAS No 959-33-1) is a flavonoid derivative often studied in the field of biomedical research It originates from the chalcone family known for diverse biological activities Its mechanism of action involves the modulation of key signaling pathways potentially affecting inflammatory and oxidative stress responses In vitro it exhibits biological activity in the nanomolar to low micromolar range showcasing its potency Common applications include studies using various cancer cell lines where it is tested for antiproliferative effects It is also utilized in animal models to explore its therapeutic potential in disease contexts In drug screening it serves as a candidate for evaluating new therapeutic strategies due to its bioactive properties Experimental concentrations typically depend on the specific research design allowing for flexibility in application across different experimental setups ensuring adaptability to varied research objectives
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 5 G
4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity. This product is intended for research use only.
- Regulates adipocyte differentiation via PPARγ activation
- Modulates adipokine expression and secretion involved in insulin sensitivity
- Increases mRNA expression of adipogenic genes during differentiation
- Reduces upregulated mRNA expression of IL-6, PAI-1, and MCP-1
- Causes an increase in PPARγ expression during differentiation
- Exhibits antiproliferative activity and cytotoxicity against various human cell lines
- Targets PPARγ
- Derived from Piperaceae Piper nigrum Linn.
- Classified as flavonoids, chalcones
Medchemexpress LLC PI3K/AKT-IN-1 | 3033069-84-7 | 99.6% | C23H23N5O4S | 25 MG
PI3K/AKT-IN-1 is an effective dual inhibitor of PI3K and AKT, exhibiting anticancer activity by inhibiting the PI3K/AKT axis and inducing caspase 3-dependent apoptosis. This compound has high cytotoxic activity against leukemia K562 and breast cancer MCF-7 cell lines, and is intended for research use only.
- Demonstrates high cytotoxic activity, particularly against leukemia cell line K562 (IC50=2.62 μM) and breast cancer cell line MCF-7 (IC50=3.22 μM)
- Promotes S-phase cell cycle arrest and induces apoptosis in K562 cells
- Significantly reduces the expression of PI3K, p-PI3K, AKT, p-AKT, Cyclin D1, and NF-κB
- Found to be non-toxic and well-tolerated in animal studies, with an LD50 greater than 2000 mg/kg
- Soluble in DMSO at 50 mg/mL
- Solid, off-white to light yellow appearance
Medchemexpress LLC Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) | 4197-97-1 | 5 MG
Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound isolated from Helichrysum Trilineatum. It facilitates AMP-activated protein kinase (AMPK) activation, which improves glucose tolerance, increases muscle fatty acid oxidation (FAO), and reduces fat accumulation in the liver and skeletal muscles of high-fat diet-induced (HFD) diabetic mice. These properties make Pinocembrin chalcone a promising compound for research related to gastric ulcers and diabetes.
- Antibacterial activity: Inhibits the growth of S. aureus in vitro.
- Metabolic regulation: Significantly increases the fatty acid oxidation rate and enhances the phosphorylation of AMPKα in C2C12 myotubes.
- Anti-diabetic effects: Improves glucose tolerance and reduces fat accumulation in the liver and muscles in HFD-induced diabetic mice.
TARGETMOL CHEMICALS INC Naringenin 1G
Also available in 1 mL, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA. Purity 98.81%
Medchemexpress LLC (±)-Naringenin (Standard) | 67604-48-2 | 98.8% | 272.25 | 100 MG
(±)-Naringenin (Standard) is the analytical standard of (±)-Naringenin, intended for research and analytical applications. It is a naturally-occurring flavonoid that displays a vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
- Analytical standard grade
- Naturally-occurring flavonoid
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
- Appearance: solid, white to light yellow
- Structure classification: flavonoids, phenols
- Initial source: plants other families
- Displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.