Linear 1 3-diarylpropanoids
Medchemexpress LLC Naringin Dihydrochalcone | 18916-17-1 | 99.2% | 582.55 | 5 G
Naringin Dihydrochalcone is an artificial sweetener synthesized from naringin, a flavanone glycoside naturally found in citrus fruits like tomatoes and grapefruits. It demonstrates various biological properties, including antioxidant, anti-inflammatory, and antiapoptotic effects, and is known to suppress the NF-κB signaling pathway.
- Artificial sweetener.
- Derived from naringin, a flavanone glycoside.
- Exhibits antioxidant, anti-inflammatory, and antiapoptotic activities.
- Suppresses NF-κB signaling pathway.
- Inhibits high glucose-induced proliferation and oxidative stress in HBZY-1 cells.
- Induces autophagic cell death in AGS cancer cells.
- Protects PC12 cells from neurotoxicity and enhances antioxidant defense.
- Alleviates renal injury, collagen deposition, and fibrosis in diabetic rats.
- Improves learning, memory, and insulin signaling in high-fat diet-induced obese mice.
Medchemexpress LLC (E)-naringenin chalcone | 25515-46-2 | MFCD00016762 | 98.9% | 272.26 g/mol | C15H12O5 | 10 MG
(E)-Naringenin chalcone is a flavonoid-derived chalcone supplied for research use. It is described as an orally active anti-allergic agent with reported antioxidant, anti-inflammatory, and anticancer activities. The compound is provided as a light yellow solid with high purity and is intended for laboratory studies and small-molecule assays.
- Orally active anti-allergic agent and antioxidant.
- Reported anti-inflammatory and anticancer activity for research studies.
- Light yellow solid appearance suitable for handling in laboratory assays.
- High purity (~98.9%) for reproducible experimental results.
- Molecular weight 272.26 g/mol; formula C15H12O5.
- Store sealed away from moisture and light; recommended cold storage conditions for solutions.
Medchemexpress LLC Trans-chalcone | 614-47-1 | 98.8% | 208.26 g·mol⁻¹ | C15H12O | 50g
trans-Chalcone isolated from Aronia melanocarpa skin is a biphenolic core structure of flavonoids precursor trans-Chalcone is a potent fatty acid synthase (FAS) and -amylase inhibitor trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7 trans-Chalcone has antifungal and anticancer activity[1][2][3]
Medchemexpress LLC 4'-Hydroxychalcone | 2657-25-2 | 1 ML
4'-Hydroxychalcone is a chalcone isolated from licorice root with hepatoprotective activity. It inhibits TNFa-induced NF-κB activation via proteasome inhibition. It also induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria.
- Isolated from licorice root
- Exhibits hepatoprotective activity
- Inhibits TNFa-induced NF-κB activation through proteasome inhibition
- Induces rapid potassium release from mitochondrial vesicles
- Causes deterioration of respiratory control and oxidative phosphorylation
- Affects cancer cell viability
Medchemexpress LLC Trans-chalcone | 614-47-1 | MFCD00003082 | 98.8% | 208.26 | C15H12O | 25g
trans-Chalcone isolated from Aronia melanocarpa skin is a biphenolic core structure of flavonoids precursor trans-Chalcone is a potent fatty acid synthase (FAS) and -amylase inhibitor trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7 trans-Chalcone has antifungal and anticancer activity[1][2][3]
Apexbio Technology LLC Naringenin 480-41-1 100mg
Naringenin (CAS 480-41-1) is a small-molecule inhibitor designed to modulate inflammatory and antiviral pathways thereby regulating cellular inflammatory responses and viral replication Naringenin exerts its biological activity primarily through inhibition of the NF- B pathway resulting in reduced inflammatory cytokine production Additionally it demonstrates antioxidative properties by scavenging reactive oxygen species (ROS) In in vitro studies naringenin exhibits inhibition of dengue virus replication with reported IC50 values ranging from approximately 52 64 M to 143 M depending on experimental conditions and viral strains Based on these pharmacological properties naringenin holds research potential in inflammation oxidative stress-related cellular models and dengue virus infection studies
Medchemexpress LLC Chalcone | 94-41-7 | 100.0% | 50 MG
Chalcone is the parent α,β-unsaturated ketone scaffold used widely as a small-molecule research chemical and synthetic building block. Provided as a high-purity solid, it is used in medicinal chemistry, biochemical assays, and the synthesis of chalcone derivatives. Typical identifiers: CAS 94-41-7; formula C15H12O; molecular weight 208.25 g/mol.
- High purity suitable for research use.
- Useful building block for synthesis of bioactive derivatives.
- Compatible with DMSO; available as solution for screening.
- Supplied with certificate of analysis and safety data for quality and safety.
- Available in small-scale quantities for discovery research.
Medchemexpress LLC Phospho-AKT Thr308 100uL | 100uL
Phospho-AKT(Thr308) Antibody (YA5837) (YA5837) is a Rabbit-derived and non-conjugated IgG monoclonal antibody targeting to Phospho-AKT(Thr308)
Medchemexpress LLC Trans-chalcone | 614-47-1 | MFCD00003082 | 98.8% | 208.26 | C15H12O | 1mL
trans-Chalcone isolated from Aronia melanocarpa skin is a biphenolic core structure of flavonoids precursor trans-Chalcone is a potent fatty acid synthase (FAS) and -amylase inhibitor trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7 trans-Chalcone has antifungal and anticancer activity[1][2][3]
Medchemexpress LLC (±)-Naringenin | 67604-48-2 | 99.8% | 272.26 | 50 G
(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. It promotes vasodilation in endothelial cells by activating BKCa channels in muscle cells and exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research.
- Regulates acute and chronic inflammation responses
- Exhibits antioxidant effects
- Provides neuroprotective benefits
- Offers liver-protective properties
- Shows anti-cancer effects
- Promotes vasodilation in endothelial cells
- Inhibits Toll-like receptor 4/NF-κB signaling
Medchemexpress LLC Naringenin chalcone | 73692-50-9 | MFCD00016762 | 100 MG
Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. It induces apoptosis and inhibits the production of MCP-1 and NO. This compound exhibits anticancer activity against glioblastoma and possesses anti-inflammatory and anti-allergic properties. Intended for research use only.
- Induces apoptosis in glioblastoma cells.
- Inhibits production of MCP-1, TNF-α, and NO in macrophages.
- Increases adiponectin mRNA levels and protein secretion in adipocytes.
- Reduces eosinophilic airway inflammation and airway hyperresponsiveness.
- Suppresses Th2 cytokine production and reduces mucus overproduction.
- Reduces tumor volume and weight in glioblastoma xenograft models.
- Increases plasma adiponectin levels in diabetic mice.
- Inhibits anaphylactic response to IgE-mediated passive cutaneous anaphylaxis.
Medchemexpress LLC Chalcone dibromide | 611-91-6 | 95.0% | 368.06 g/mol | C15H12Br2O | 100 MG
Chalcone dibromide is a dibrominated chalcone derivative supplied as a white to off-white solid for research use. It serves as a versatile synthetic building block and bioactive compound in medicinal chemistry and organic synthesis, commonly used to prepare heterocycles and to evaluate biological activity.
- Dibrominated chalcone useful as a synthetic intermediate.
- Solid, white to off-white appearance for easy handling.
- Reported purity of 95.0% for research applications.
- Available in multiple pack formats including 100 mg and DMSO solutions.
- Structural identifiers provided (SMILES) to support characterization.
Medchemexpress LLC Pinocembrin chalcone | 4197-97-1 | 1 MG
Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound derived from *Helichrysum Trilineatum*. It facilitates AMP-activated protein kinase (AMPK) activation, improves glucose tolerance, increases muscle fatty acid oxidation (FAO), and reduces fat accumulation in the liver and skeletal muscles of high-fat diet-induced (HFD) diabetic mice. It is suitable for research on gastric ulcers and diabetes.
- Antibacterial properties
- Activates AMP-activated protein kinase (AMPK)
- Improves glucose tolerance
- Increases muscle fatty acid oxidation
- Reduces fat accumulation in liver and skeletal muscles
- Supports research on gastric ulcers and diabetes
Medchemexpress LLC AKT-IN-23 | 1226801-23-5 | 517.52 | 5 MG
AKT-IN-23 is an AKT inhibitor that can be used in cancer research. This product is designed for research use only and has not been fully validated for medical applications.
- Can be used in cancer research
- Inhibitor of AKT