Linear 1 3-diarylpropanoids
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 5 G
4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity. This product is intended for research use only.
- Regulates adipocyte differentiation via PPARγ activation
- Modulates adipokine expression and secretion involved in insulin sensitivity
- Increases mRNA expression of adipogenic genes during differentiation
- Reduces upregulated mRNA expression of IL-6, PAI-1, and MCP-1
- Causes an increase in PPARγ expression during differentiation
- Exhibits antiproliferative activity and cytotoxicity against various human cell lines
- Targets PPARγ
- Derived from Piperaceae Piper nigrum Linn.
- Classified as flavonoids, chalcones
Medchemexpress LLC Naringenin | 480-41-1 | 99.3% | 272.25 | 1 G
Naringenin is the predominant flavanone found in *Citrus reticulata Blanco*. It exhibits strong anti-inflammatory and antioxidant activities, and also possesses anti-dengue virus (DENV) activity.
- Exhibits strong anti-inflammatory activity.
- Exhibits strong antioxidant activity.
- Possesses anti-dengue virus (DENV) activity.
- Inhibits HepG2 cell proliferation.
- Reduces plasma and liver triglycerides and cholesterol.
- Enhances hepatic fatty acid oxidation.
Medchemexpress LLC 6-(4-(1-aminocyclobutyl)phenyl)-5-phenylnicotinamide | 1357158-81-6 | >98.0% | 343.42 g/mol | C22H21N3O | 10 MG
AKT-IN-1 is a small-molecule allosteric inhibitor of the AKT kinase family used for pathway and cancer research. It inhibits AKT with an IC50 of 1.042 μM, has CAS 1357158-81-6, and is supplied as a research-grade solid with high purity for biochemical and cellular assays.
- Allosteric AKT inhibition with IC50 = 1.042 μM.
- High chemical purity for reproducible results.
- Suitable for PI3K/Akt/mTOR pathway studies and cancer research.
- Solid form enabling flexible solution preparation.
- Molecular weight 343.42 g/mol and formula C22H21N3O for accurate dosing.
- Intended for research use only.
Medchemexpress LLC PI3K/AKT-IN-1 | 3033069-84-7 | 99.6% | C23H23N5O4S | 25 MG
PI3K/AKT-IN-1 is an effective dual inhibitor of PI3K and AKT, exhibiting anticancer activity by inhibiting the PI3K/AKT axis and inducing caspase 3-dependent apoptosis. This compound has high cytotoxic activity against leukemia K562 and breast cancer MCF-7 cell lines, and is intended for research use only.
- Demonstrates high cytotoxic activity, particularly against leukemia cell line K562 (IC50=2.62 μM) and breast cancer cell line MCF-7 (IC50=3.22 μM)
- Promotes S-phase cell cycle arrest and induces apoptosis in K562 cells
- Significantly reduces the expression of PI3K, p-PI3K, AKT, p-AKT, Cyclin D1, and NF-κB
- Found to be non-toxic and well-tolerated in animal studies, with an LD50 greater than 2000 mg/kg
- Soluble in DMSO at 50 mg/mL
- Solid, off-white to light yellow appearance
Medchemexpress LLC Chalcone 4 hydrate 1mg | 1202866-96-3 | ≈288.73 g/mol (anhydrous basis); varies with hydration (xH2O) | C16H13ClO3·xH2O | 1 MG
Chalcone 4 hydrate (CAS 1202866-96-3) is an anti-parasite small-molecule research reagent reported to inhibit the growth of Babesia and Theileria. The compound is supplied as a hydrated solid and is intended for in vitro parasitology and chemical biology studies; handle and store under recommended conditions.
- Hydrated solid form (xH2O)
- Purity 98.0%
- Molecular formula C16H13ClO3·xH2O
- Typical molecular weight ~288.73 g/mol (anhydrous basis)
- Offered in low-quantity research sizes (e.g., 1 mg)
- Store at 4°C; in solution, store -80°C up to 6 months or -20°C up to 1 month under nitrogen
Medchemexpress LLC Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) | 4197-97-1 | 5 MG
Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound isolated from Helichrysum Trilineatum. It facilitates AMP-activated protein kinase (AMPK) activation, which improves glucose tolerance, increases muscle fatty acid oxidation (FAO), and reduces fat accumulation in the liver and skeletal muscles of high-fat diet-induced (HFD) diabetic mice. These properties make Pinocembrin chalcone a promising compound for research related to gastric ulcers and diabetes.
- Antibacterial activity: Inhibits the growth of S. aureus in vitro.
- Metabolic regulation: Significantly increases the fatty acid oxidation rate and enhances the phosphorylation of AMPKα in C2C12 myotubes.
- Anti-diabetic effects: Improves glucose tolerance and reduces fat accumulation in the liver and muscles in HFD-induced diabetic mice.
Medchemexpress LLC Naringenin | 480-41-1 | MFCD00006844 | 272.25 | 100 MG
Naringenin, a predominant flavanone found in Citrus reticulata Blanco, exhibits strong anti-inflammatory and antioxidant activities. It also demonstrates anti-dengue virus (DENV) activity. Research indicates Naringenin can inhibit proliferation of HepG2 cells by inducing G0/G1 and G2/M phase accumulation and apoptosis. It also reduces viability of A431 cells and has shown potential to reduce plasma and liver triglycerides, cholesterol, and adiposity.
- Displays strong anti-inflammatory and antioxidant activities.
- Exhibits anti-dengue virus (DENV) activity.
- Inhibits HepG2 cell proliferation.
- Induces G0/G1 and G2/M phase accumulation.
- Reduces A431 cell viability.
- Reduces plasma and liver triglycerides and cholesterol.
- Increases hepatic PPARα protein expression.
- Inhibits TNF-α-induced VSMC proliferation.
Medchemexpress LLC Trans-chalcone | 614-47-1 | MFCD00003082 | 98.8% | 208.26 g/mol | C15H12O | 500g
trans-Chalcone isolated from Aronia melanocarpa skin is a biphenolic core structure of flavonoids precursor trans-Chalcone is a potent fatty acid synthase (FAS) and -amylase inhibitor trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7 trans-Chalcone has antifungal and anticancer activity[1][2][3]
Medchemexpress LLC (±)-Naringenin (Standard) | 67604-48-2 | 98.8% | 272.25 | 100 MG
(±)-Naringenin (Standard) is the analytical standard of (±)-Naringenin, intended for research and analytical applications. It is a naturally-occurring flavonoid that displays a vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
- Analytical standard grade
- Naturally-occurring flavonoid
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
- Appearance: solid, white to light yellow
- Structure classification: flavonoids, phenols
- Initial source: plants other families
- Displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.