Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties, primarily used as a bactericidal antibiotic to treat tuberculosis. It inhibits DNA-dependent RNA polymerase and is effective against highly resistant mycobacteria, Gram-positive bacteria, some Gram-negative bacteria, and specific *Mycobacterium* species like *M. tuberculosis*, *M. leprae*, and *M. avium intracellulare*.
- Inhibits DNA-dependent RNA polymerase.
- Effective against highly resistant mycobacteria.
- Interferes with HSP-90 molecular chaperone.
- Enhances ubiquitination and protein degradation.
- Inactivates bacterial RNA polymerase.