Rolitetracycline is a highly soluble, broad-spectrum antibiotic derived from tetracycline. It inhibits HIV-1 integrase, blocks Aβ fibril formation, and suppresses dengue virus proliferation. It mediates the inhibition of Aβ fibrils via a specific three-dimensional pharmacophore conformation and exhibits bacteriostatic and bactericidal activities. It acts synergistically with Penicillin G or Cephalothin and is a tool compound for studying bacterial infections (urinary tract infections, sepsis), HIV-1 and dengue virus infections, and Alzheimer's disease.
- Highly soluble, broad-spectrum antibiotic
- Inhibits HIV-1 integrase
- Blocks Aβ fibril formation
- Suppresses dengue virus proliferation
- Bacteriostatic and bactericidal
- Acts synergistically with Penicillin G or Cephalothin
- Tool compound for studying bacterial infections, HIV-1, dengue virus infections, and Alzheimer's disease