Metalloid Salts
Medchemexpress LLC Cycloartenol | 469-38-5 | 1 MG
Cycloartenol is a phytosterol compound and a key precursor for the biosynthesis of numerous sterol compounds. It exhibits various pharmacological activities including anti-inflammatory, anti-tumor, antioxidant, antibiosis, and anti-Alzheimer's disease effects. It also plays a significant role in plant growth and development.
- Inhibits migration of glioma cells.
- Suppresses phosphorylation of p38 MAP kinase.
- Induces Sub-G1 cell cycle arrest and apoptosis in glioma U87 cells.
- Significantly alters the expression of Bax and Bcl-2.
- Acts as a precursor for sterol biosynthesis.
Medchemexpress LLC Astragaloside IV | 84687-43-4 | 784.97 | 1 ML
Astragaloside IV, an active component isolated from *Astragalus membranaceus*, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
- Suppresses ERK1/2 and JNK activation
- Downregulates matrix metalloproteases (MMP)-2 and (MMP)-9
- Inhibits NSCLC cell growth and increases chemosensitivity to cisplatin
- Inhibits viability and invasive potential of MDA-MB-231 breast cancer cells
- Prevents cognitive deficits from cerebral ischemia and reperfusion
- Decreases cytokine levels and inhibits TLR4 pathways
- Attenuates NLRP3 and cleaved-caspase-1 expression
- Reduces serum ALT/AST levels and liver apoptosis
- Increases 48-hour survival rate in mice
Apexbio Technology LLC HYPERSCRIPT IV RTASE-40000mg
HyperScript IV Reverse Transcriptase is a pivotal enzyme in molecular biology research primarily used in the synthesis of complementary DNA (cDNA) from RNA templates Originating from retroviral sources this enzyme is crucial for studies involving gene expression analysis cloning and RNA sequencing It operates through a mechanism that reverses the transcription process effectively converting single-stranded RNA into stable cDNA Its activity is measured in the nanomolar to low micromolar range demonstrating high efficiency and reliability under in vitro conditions This enzyme is extensively applied in various experimental settings including cell models animal studies and high-throughput drug screening assays Experimental concentrations typically depend on the specific research design Using this advanced reverse transcriptase researchers can achieve precise and reproducible amplification of genetic material facilitating significant advancements in biomedical research
Apexbio Technology LLC HYPERSCRIPT IV RTASE-2000mg
HyperScript IV Reverse Transcriptase is a pivotal enzyme in molecular biology research primarily used in the synthesis of complementary DNA (cDNA) from RNA templates Originating from retroviral sources this enzyme is crucial for studies involving gene expression analysis cloning and RNA sequencing It operates through a mechanism that reverses the transcription process effectively converting single-stranded RNA into stable cDNA Its activity is measured in the nanomolar to low micromolar range demonstrating high efficiency and reliability under in vitro conditions This enzyme is extensively applied in various experimental settings including cell models animal studies and high-throughput drug screening assays Experimental concentrations typically depend on the specific research design Using this advanced reverse transcriptase researchers can achieve precise and reproducible amplification of genetic material facilitating significant advancements in biomedical research
Sigma Aldrich Fine Chemicals Biosciences NOX Inhibitor IV GKT136901
An orally bioavailable non-toxic pyrazolopyridinedione based compound that acts as a potent and reversible inhibitor of NOX1- and NOX4-containing NADPH oxidase activity (Ki 160 and 165 nM respectively Amplex Red assay) and devoid of antioxidant properties. At higher concentrations affects NOX2 (Ki 1.53 uM). Blocks NOX-mediated ROS (reactive oxygen species) outburst in NOX isozyme expressing PMN cell membranes. Exhibits poor affinity towards xanthine oxidase lipoxygenases-5/12 myeloperoxidase MAO-B iNOS and eNOS several cytochrome P450 isozymes PTP1B and a panel containing representative ion-channels and kinases at 10 181M. functions as a selective scavenger of peroxynitrite over nitric oxide superoxide radical anion and hydroxyl radical.Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided re
