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Aromatic organic compounds that consist of a phenyl functional group (−C6H5) bonded to a hydroxyl functional group (−OH). Includes compounds with more substitutions and derivatives.
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P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. It inhibits H+/K+-ATPase activity with an IC50 value of <100 nM and the hERG potassium channel with an IC50 value of 18.69 M. This agent shows no acute toxicity and inhibits histamine-induced gastric acid secretion.
Potent and orally active potassium-competitive acid blocker
Inhibits H+/K+-ATPase activity
Inhibits hERG potassium channel
Shows no acute toxicity
Inhibits histamine-induced gastric acid secretion
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