Phenols
Medchemexpress LLC AT-533 | 908112-37-8 | 98.4% | 410.51 | 50 MG
AT-533 is a potent inhibitor of Heat Shock Protein 90 (Hsp90) and Herpes Simplex Virus (HSV). It demonstrates anti-tumor and anti-angiogenic properties by targeting the HIF-1α/VEGF/VEGFR-2 signaling pathway, and suppresses downstream pathways including Akt/mTOR/p70S6K, Erk1/2, and FAK.
- Potent Hsp90 and HSV inhibitor.
- Suppresses tumor growth and angiogenesis.
- Inhibits key signaling pathways: Akt/mTOR/p70S6K, Erk1/2, and FAK.
- Reduces tube formation, cell migration, and invasion in HUVECs.
- Demonstrates anti-angiogenic activity in CAM models.
- Decreases inflammatory markers TNF-α, IL-1β, and IL-6.
- Shows no adverse reactions in subacute toxicology studies.
Sigma Aldrich Fine Chemicals Biosciences 1,2,4-Benzenetriol ReagentPlus(R), 99% | 533-73-3 | MFCD00002198 | 5G
1,2,4-Benzenetriol ReagentPlus(R), 99% | Purity: 99% | Mol Wt: 126.11 | 533-73-3 | MFCD00002198 | 5G
Medchemexpress LLC At-533 | 908112-37-8 | 98.4% | 410.51 g/mol | C23H30N4O3 | 10 MG
AT-533 is a small-molecule inhibitor of Hsp90 with reported antiviral activity against herpes simplex virus (HSV). It suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway and inhibits downstream signaling including Akt/mTOR/p70S6K, Erk1/2, and FAK, making it useful as a research reagent in cell biology and preclinical studies.
- Potent Hsp90 and HSV inhibitory activity.
- Blocks HIF-1α/VEGF/VEGFR-2 signaling to suppress tumor growth and angiogenesis.
- Inhibits downstream Akt/mTOR/p70S6K, Erk1/2, and FAK pathways.
- Reduces tube formation, migration, and invasion in endothelial cell assays.
- High purity suitable for research applications.
- Stable as powder under recommended cold storage.
Medchemexpress LLC AT-533 | 908112-37-8 | 98.4% | 410.51 | 100 MG
AT-533 is a potent Hsp90 and HSV inhibitor. It suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling pathway and inhibits the activation of downstream pathways such as Akt/mTOR/p70S6K, Erk1/2, and FAK. Additionally, it inhibits the tube formation, cell migration, and invasion of human umbilical vein endothelial cells (HUVECs).
- Potent Hsp90 and HSV inhibitor
- Suppresses tumor growth
- Inhibits angiogenesis by blocking HIF-1α/VEGF/VEGFR-2 signaling
- Inhibits Akt/mTOR/p70S6K, Erk1/2, and FAK pathways
- Inhibits tube formation, cell migration, and invasion of HUVECs
- Shows anti-angiogenic ability in CAM model
- Decreases TNF-α, IL-1β, and IL-6 production
- No significant toxicity in animal studies
Medchemexpress LLC Pp60 c-src (521-533) (phosphorylated) | 149299-77-4 | 98.8% | 1543.48 | 1 MG
pp60 c-src (521-533) (phosphorylated) is a peptide corresponding to the pp60c-src carboxy terminal regulatory domain. This product is phosphorylated at Tyr527 and is intended for research applications.
- Peptide corresponding to pp60c-src carboxy terminal regulatory domain
- Phosphorylated at Tyr527
- Molecular weight of 1543.48
- CAS number 149299-77-4
- Purity of 98.8%
- Appears as a white to off-white solid
- Soluble in DMSO at 100 mg/mL
eMolecules 3,4,5-Trihydroxybenzamide | 618-73-5 | MFCD00014800 | 25g
Combi-Blocks, Inc. | 3,4,5-Trihydroxybenzamide | 25g | 569295508 | QF-3553 | 95.000 | 618-73-5 | MFCD00014800 | 169.136 | C7H7NO4
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eMolecules Ambeed / Bromo-peg3-t-butyl ester / 100mg / 600847038 / A750957 / / 782475-37-0 / MFCD22574821 / 341.242 / C13H25BrO5
Ambeed / Bromo-peg3-t-butyl ester / 100mg / 600847038 / A750957 / / 782475-37-0 / MFCD22574821 / 341.242 / C13H25BrO5
Medchemexpress LLC Mavorixafor hydrochloride | 880549-30-4 | 99.6% | C21H28ClN5 | 25 MG
Mavorixafor hydrochloride is a potent, selective, and orally available CXCR4 antagonist. It exhibits an IC50 value of 13 nM against CXCR4 125I-SDF binding. This compound also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with IC50 values of 1 nM and 9 nM, respectively, making it suitable for WHIM syndrome research. It demonstrates no effect on other chemokine receptors such as CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2.
- Potent and selective CXCR4 antagonist
- Orally available for ease of administration
- Inhibits T-tropic HIV-1 replication
- Useful for WHIM syndrome studies
- Suppresses anchorage-dependent cell growth
- Impairs cell motility and inhibits migration
- Prevents Matrigel invasion and lung metastasis in in vivo models
Medchemexpress LLC Samuraciclib hydrochloride | 1805789-54-1 | MFCD31657343 | 99.9% | 430.97 g/mol | C22H31ClN6O | 100 MG
Samuraciclib hydrochloride is a potent, selective, ATP-competitive, and orally active inhibitor of cyclin-dependent kinase 7 (CDK7) used in preclinical research. It inhibits proliferation of cancer cell lines and has demonstrated anti-tumor activity in vitro, making it a tool compound for studying CDK7-related transcriptional control and apoptosis pathways.
- Potent, selective CDK7 inhibition (IC50 ~41 nM).
- Orally active compound suitable for in vitro and preclinical studies.
- Shown to inhibit cancer cell growth (GI50 0.2-0.3 μM in breast cancer lines).
- Applicable for research on transcriptional regulation and apoptosis mechanisms.
- Supplied as a stable solid with recommended refrigerated storage to maintain integrity.
Medchemexpress LLC MIP-3 beta/CCL19 Mo 10ug
MIP-3 beta/CCL19 Protein Mouse is a CC chemokine that is strongly chemotactic for CD4 T cells and CD8 T cells and acts as a ligand that binds specifically to the chemokine receptor CCR7 to mediate tissue immunity inflammatory responses and antiviral infections MIP-3 beta/CCL19 Protein Mouse is a recombinant mouse MIP-3 beta/CCL19 (G26-S108) protein expressed by E coli[1][2]
Medchemexpress LLC Ziprasidone hydrochloride monohydrate | 138982-67-9 | 98.1% | 467.41 | 5 MG
Ziprasidone (CP-88059) hydrochloride monohydrate is an orally active combined 5-HT and dopamine receptor antagonist. It shows affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM) receptors. It is for research use only.
- Orally active combined 5-HT and dopamine receptor antagonist.
- Shows affinities for Rat D2, 5-HT2A, and 5-HT1A receptors.
- Blocks wild-type hERG current in HEK-293 cells.
- In vivo studies show weight loss and increased thermogenesis.
- Involved in clinical trials for schizophrenia and bipolar disorder.
Ambeed 2 4 Bromomethyl phenyl 4 4 5 5
2-(4-(Bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 138500-85-3, 97%
Medchemexpress LLC Mardepodect hydrochloride | 2070014-78-5 | 99.9% | 10 MG
Mardepodect hydrochloride is the hydrochloride salt of mardepodect (PF-2545920), a potent and selective phosphodiesterase 10A (PDE10A) inhibitor used in neuroscience research. It is supplied as a solid hydrochloride salt with high reported purity and is used for in vitro and in vivo studies of PDE10A-related signaling and CNS pharmacology.
- Potent, selective PDE10A inhibitor (reported IC50 = 0.37 nM).
- High reported purity, suitable for research applications.
- Hydrochloride salt form for improved solubility compared with the free base.
- Known to cross the blood-brain barrier, relevant for CNS studies.
- Chemical formula C25H21ClN4O and molecular weight 428.91.
- Provided as a small solid quantity appropriate for early-stage experiments.