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Aromatic organic compounds that consist of a phenyl functional group (−C6H5) bonded to a hydroxyl functional group (−OH). Includes compounds with more substitutions and derivatives.
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m-PEG2-acid is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. These molecules function by harnessing the intracellular ubiquitin-proteeasome system to selectively degrade target proteins.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
Consists of two distinct ligands connected by a linker
Targets an E3 ubiquitin ligase
Targets a specific protein
Harnesses the intracellular ubiquitin-proteasome system
Selectively degrades target proteins
For research use only
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Bis-NH2-PEG2 is a PEG-based linker utilized in the creation of protein degraders. These degraders are designed to harness the cell's natural waste disposal system, the ubiquitin-proteasome pathway, to selectively eliminate specific proteins. This product acts as a crucial connector in the construction of such protein-degrading molecules, linking a ligand for an E3 ubiquitin ligase with a ligand for a target protein.
Serves as a foundational component for synthesizing protein degraders.
Instrumental in promoting targeted protein degradation.
Has a purity of 99.8%.
Supplied in a liquid form.
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Casein phosphopeptide is a research-grade peptide mixture derived from casein, used as a biochemical reagent in life-science assays and characterization studies. Supplied as a white to off-white solid, it is intended for laboratory research applications and should be stored according to supplier recommendations for stability.
Derived from casein and intended for biochemical research applications.
White to off-white solid form suitable for laboratory handling.
Supplied as a 25 G package for laboratory use.
Protein content reported as 82.0% per certificate of analysis.
Identified by CAS number 691364-49-5 for substance reference.
Stable under frozen storage; follow supplier storage guidance for shelf life.
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Sotalol hydrochloride is an orally active, non-selective β-adrenergic receptor blocker and a potent antiarrhythmic agent. It is suitable for research on pediatric arrhythmias and also functions as an antiepileptic agent. This compound works by blocking β-receptors and potassium KCNH2 channels.
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Clemizole hydrochloride is a histamine H1 receptor antagonist reported to inhibit hepatitis C virus (HCV) replication by targeting the viral NS4B protein a component essential for viral RNA replication Clemizole demonstrates antiviral activity in vitro against HCV genotype 2a subgenomic replicons exhibiting an IC50 value around 8 mM When combined with HCV protease inhibitors (such as VX950 or SCH503034) clemizole displays synergistic antiviral effects In contrast additive antiviral effects occur in combination with interferon ribavirin or polymerase inhibitors Clemizole is utilized in research contexts aimed at evaluating its efficacy potential antiviral combinations metabolism pathways and pharmacokinetics relevant to its consideration as a therapeutic candidate for HCV infection
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Oxindole (Indolin-2-one) is an aromatic heterocyclic building block 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors
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