Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and CNS-penetrant Rho Kinase (ROCK) inhibitor with a ROCK2 IC50 of 3 nM, making it suitable for Huntington's research. It increases AKT phosphorylation and decreases MYPT1 phosphorylation both in vitro and in vivo. This product is intended for research use only.
- Orally active, selective, and CNS-penetrant ROCK inhibitor
- Targeted inhibition of ROCK2 with an IC50 of 3 nM
- Increases AKT phosphorylation and decreases MYPT1 phosphorylation in A7r5 and PANC1 cells
- Demonstrates dose- and time-dependent ROCK1 and ROCK2 target engagement in vivo
- Shows excellent tolerability in mouse models
- Decreases mean arterial, systolic, and diastolic blood pressure and heart rate in CD1 mice