Carboxylic acids and derivatives
Medchemexpress LLC Sparfosic acid trisodium | 70962-66-2 | 98.0% | 321.06 | 100 MG
Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase, an enzyme that catalyzes the second step of de novo pyrimidine biosynthesis. It synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines. This product is for research use only and not intended for sale to patients.
- Potent inhibitor of aspartate transcarbamoyl transferase.
- Synergistically enhances cytotoxicity of 5-FU and IFN against human colon cancer cell lines.
- Causes apoptosis in resistant Br1 cells.
- Leads to progressive accumulation of cells in S phase and activation of an apoptotic pathway.
- Increases lifespan and is curative in mice models of B16 melanoma and Lewis lung carcinoma.
TARGETMOL CHEMICALS INC Zoledronic acid monohydrate
Also available in 10 mg, 25 mg, 50 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity. Purity ≥95%
Medchemexpress LLC (Z)-aconitic acid | 585-84-2 | MFCD00063184 | 99.3% | 174.11 g/mol | C6H6O6 | 5 MG
(Z)-aconitic acid is a small-molecule endogenous metabolite (cis-aconitic acid) reported to act as a glutamate decarboxylase inhibitor with activity that includes reduction of IκB-α phosphorylation and inhibition of inflammatory responses; supplied as a solid for research use.
- Molecular formula C6H6O6 and molecular weight 174.11 g/mol.
- High reported purity (99.28%).
- Reported activity as a glutamate decarboxylase inhibitor and modulator of IκB-α phosphorylation.
- Applicable to research on inflammatory and metabolic pathways.
- Powder stability: -20°C for long-term storage; defined solvent storage conditions available.
Selleck Chemical LLC Toremifene Citrate (NK 622) S1776-1g
Toremifene Citrate (NK 622 NSC 613680) is an oral selective estrogen receptor modulator (SERM) used in the treatment of advanced breast cancer
Apexbio Technology LLC Toremifene Citrate 89778-27-8 10mM (in 1mL DMSO)
Toremifene Citrate (CAS 89778-27-8) is a small-molecule selective estrogen receptor modulator (SERM) targeting estrogen receptors It is designed to modulate estrogen receptor signaling pathways thereby regulating estrogen-dependent cellular functions Toremifene Citrate exerts its biological activity primarily through tissue-specific antagonism or partial agonism of the estrogen receptor In in vitro studies Toremifene Citrate demonstrates receptor binding activity with an affinity of 1 M for the estrogen receptor Based on these pharmacological properties Toremifene Citrate holds research potential in investigating estrogen-dependent regulatory processes and endocrine signaling dynamics
Selleck Chemical LLC Glyoxylic acid monohydrate S3092-100mg
Glyoxylic acid monohydrate (2 2-Dihydroxyacetic acid) is an atmospherically relevant ketoacid
Medchemexpress LLC 5,8,11-Trioxa-2-azatridecanedioic acid, 1-(1,1-dimethylethyl) ester | 462100-06-7 | ≥97.0% | 307.34 | 250 MG
Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTAC. PROTACs (Proteolysis Targeting Chimeras) consist of two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase and the other is for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used as a PEG-based PROTAC linker
- Suitable for PROTAC synthesis
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC 2-methylcitric acid trisodium | 117041-96-0 | MFCD16875437 | 96.0% | 272.10 g·mol⁻1 | C7H7Na3O7 | 5 MG
2-Methylcitric acid trisodium is the trisodium salt of 2-methylcitric acid provided as a white to off-white solid for laboratory research. It is an endogenous metabolite used as a marker in methylmalonic and propionic acidemias and is employed in biochemical and mitochondrial studies, where it has been reported to inhibit ADP-stimulated mitochondrial respiration supported by glutamate.
- Trisodium salt, white to off-white solid.
- CAS number 117041-96-0.
- Purity 96.0%.
- Molecular weight 272.10 g·mol⁻1; formula C7H7Na3O7.
- Highly soluble in water (100 mg/mL; may require ultrasonication).
- Storage: sealed at 4°C; in solvent -80°C (6 months), -20°C (1 month).
- For research use only; not for human or veterinary use.