Asenapine maleate, also known by its synonym Org 5222 maleate, is a brain-penetrant atypical antipsychotic. It acts as an antagonist for various receptors, including serotonin, adrenoceptors, dopamine, and histamine receptors. It is investigated for its potential in treating schizophrenia and bipolar disorder.
- Acts as an antagonist of serotonin receptors.
- Exhibits antagonism towards adrenoceptors.
- Functions as a dopamine receptor antagonist.
- Blocks histamine receptors.
- Investigated for its use in schizophrenia.
- Studied for application in bipolar disorder.
- May offer superior therapeutic effects on anxiety symptoms.
- Demonstrates anxiolytic-like effects in behavioral tests in mice.