Filgotinib maleate (GLPG0634 maleate) is a selective, orally available JAK1 inhibitor with anti-inflammatory and antiviral activities. It can effectively inhibit the activities of JAK1, JAK2, JAK3, and TYK2. This compound also inhibits HIV-1 driven gene transcription and reduces proliferation of HIV-1 infected cells. It can be used in the study of rheumatoid arthritis and inflammatory bowel disease.
- Selective, orally available JAK1 inhibitor
- Anti-inflammatory and antiviral activities
- Inhibits activities of JAK1, JAK2, JAK3, and TYK2
- Inhibits HIV-1 driven gene transcription
- Reduces proliferation of HIV-1 infected cells
- Suitable for research in rheumatoid arthritis and inflammatory bowel disease