Carboxylic acids and derivatives
Medchemexpress LLC Neratinib maleate | 915942-22-2 | 99.7% | 673.11 | 50 MG
Neratinib maleate (HKI-272 maleate) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor. It is intended for research use only.
- Inhibits HER2 and EGFR with IC50s of 59 nM and 92 nM, respectively.
- Demonstrates antiproliferative effects in cell lines with high HER-2 levels.
- Arrests cell cycle at G1-S phase in BT474 cells.
- Inhibits MAPK and Akt phosphorylation, and induces p27.
- Exhibits anticancer activities against HER-2 or EGFR expressing cancer cells in vivo.
- Reduces tumor growth in xenograft models.
Apexbio Technology LLC Rosiglitazone maleate(Synonyms: Avandia, BRL 49653, BRL49653C, Rosiglitazone maleate salt, BRL49653, RGZ, Rosiglizole maleate), 200mg, CAS: 155141-29-0.
Rosiglitazone maleate (CAS 155141-29-0) is the maleate salt formulation of rosiglitazone a thiazolidinedione compound targeting the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR ) By selective activation of PPAR rosiglitazone increases insulin sensitivity of peripheral tissues facilitating glucose uptake and reduction of blood glucose levels Due to its insulin-sensitizing activity rosiglitazone maleate serves as an important research tool in diabetes and metabolic syndrome investigations However recent clinical studies also report associations with adverse cardiovascular events fluid retention and anemia underscoring considerations for risk-benefit evaluation in ongoing research
Medchemexpress LLC Indacaterol maleate | 753498-25-8 | MFCD20526769 | 99.8% | 508.56 g/mol | C28H32N2O7 | 5 MG
Indacaterol maleate is the maleate salt of indacaterol, an ultra-long-acting β2-adrenergic receptor agonist. Supplied as an analytical standard, this solid reference material is intended for research use in assay development, method validation, and quality control testing.
- High purity (99.8%).
- Suitable for assay development and method validation.
- Confirmed identity by LC-MS consistent with structure.
- Stable solid form for accurate weighing and storage.
- Includes CAS 753498-25-8 and molecular weight 508.56 g/mol.
eMolecules 77758-51-1 | Methyl 5-hexynoate | Combi-Blocks | MFCD00671366 | 126.155 | C7H10O2 | 95.000 | COC(=O)CCCC#C | 1g | 415500572
Methyl 5-hexynoate | Combi-Blocks | 77758-51-1 | MFCD00671366 | 126.155 | C7H10O2 | 95.000 | COC(=O)CCCC#C | 1g | 415500572
eMolecules 7283-69-4 | Diisobutyl fumarate | Combi-Blocks, Inc. | MFCD00152430 | 228.288 | C12H20O4 | 98.000 | CC(C)COC(=O)\C=C\C(=O)OCC(C)C | 25g | 603134297
Diisobutyl fumarate | Combi-Blocks, Inc. | 7283-69-4 | MFCD00152430 | 228.288 | C12H20O4 | 98.000 | CC(C)COC(=O)\C=C\C(=O)OCC(C)C | 25g | 603134297
Apexbio Technology LLC NB-598 Maleate 155294-62-5 50mg
NB-598 Maleate is a small-molecule inhibitor targeting squalene epoxidase (SE) an essential enzyme in cholesterol biosynthesis It is designed to inhibit SE thereby disrupting the oxygenation of squalene and affecting downstream synthesis of cholesterol intermediates particularly within farnesol-dependent pathways leading to triglyceride biosynthesis NB-598 Maleate exerts its biological activity primarily through inhibition of squalene epoxidase In mouse pancreatic islet models NB-598 Maleate reduces insulin secretion under both basal and glucose-stimulated conditions Additionally this compound inhibits calcium voltage-dependent (CaV) ion channels in cellular assays Based on these pharmacological properties NB-598 Maleate holds research potential in studying cholesterol biosynthesis pathways lipid metabolism insulin regulation and the physiological role of CaV channels
eMolecules 217300-17-9 | Ambeed | (Triisopropylsiloxy)methyl chloride | 100mg | 589771798 | A991979 | MFCD05865265 | 222.83 | C10H23ClOSi
ChemScene | Imidazo[12-a]pyrimidin-7-amine | 25mg | 801475938 | CS-0094347 | 462651-80-5 | MFCD09909665 | 134.142 | C6H6N4
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Medchemexpress LLC Setiptiline maleate | 85650-57-3 | 99.9% | 377.43 | 50 MG
Setiptiline maleate is a serotonin receptor antagonist and a tetracyclic antidepressant (TeCA) that acts as a noradrenergic and specific serotonergic antidepressant (NaSSA).
- Functions as a norepinephrine reuptake inhibitor.
- Acts as an α2-adrenergic receptor antagonist.
- Serves as a serotonin receptor antagonist, targeting 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes.
- Acts as an H1 receptor inverse agonist/antihistamine.
TARGETMOL CHEMICALS INC ACEPROMAZINE MALEATE 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ACEPROMAZINE MALEATE is a dopamine receptor antagonistpurity: 99%
Apexbio Technology LLC Rosiglitazone maleate(Synonyms: Avandia, BRL 49653, BRL49653C, Rosiglitazone maleate salt, BRL49653, RGZ, Rosiglizole maleate), 10mM (in 1mL DMSO), CAS: 155141-29-0.
Rosiglitazone maleate (CAS 155141-29-0) is the maleate salt formulation of rosiglitazone a thiazolidinedione compound targeting the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR ) By selective activation of PPAR rosiglitazone increases insulin sensitivity of peripheral tissues facilitating glucose uptake and reduction of blood glucose levels Due to its insulin-sensitizing activity rosiglitazone maleate serves as an important research tool in diabetes and metabolic syndrome investigations However recent clinical studies also report associations with adverse cardiovascular events fluid retention and anemia underscoring considerations for risk-benefit evaluation in ongoing research
Medchemexpress LLC Way-100635 maleate | 1092679-51-0 | MFCD01321056 | 99.6% | 538.64 g/mol | C29H38N4O6 | 100 MG
WAY-100635 maleate is the maleate salt of WAY-100635, a potent and selective 5-HT1A receptor antagonist used for pharmacology and receptor-binding research. It is provided as a high-purity analytical standard suitable for in vitro and in vivo studies.
- Potent 5-HT1A receptor antagonist (IC50 = 0.91 nM; Ki = 0.39 nM).
- High purity: 99.6% (HPLC).
- Molecular weight 538.64 g/mol.
- Molecular formula C29H38N4O6.
- Supplied as a 100 mg vial for research use.
Medchemexpress LLC Diethyl maleate | 141-05-9 | MFCD00009191 | 98.1% | 172.18 | C8H12O4 | 1g
Diethyl maleate (DEM) is an orally available effective glutathione (GSH) depletor that crosses the blood-brain barrier Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0 1-0 5 mM Diethyl maleate selectively depletes GSH in liver lung and brain tissues exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter XO- Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3]
Cayman Chemical Ethynodiol Diacetate, Purity: ≥98%, CAS: 297-76-7, 5 g
A synthetic progestogen; prevents the development of osteoporosis in ovariectomized rats at 9 µg/animal per day; inhibits copulatory ovulation in rabbits
Cayman Chemical Fluorescein diacetate, Purity: ≥98%, CAS: 596-09-8, 5 g
A cell-permeable fluorogenic cell viability probe; cleaved by intracellular esterases to produce fluorescein which displays excitation/emission maxima of 490/520 nm, respectively