Carboxylic acids and derivatives
Apexbio Technology LLC GlyH-101 328541-79-3 50mg
GlyH-101 (CAS 328541-79-3) is a cell-permeable glycinyl hydrazone derivative that acts as a selective inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel exhibiting a Ki of 1 4 M By blocking CFTR-mediated chloride transport GlyH-101 serves as a valuable tool for investigating CFTR function in epithelial physiology and pathophysiology as well as for studying mechanisms underlying cystic fibrosis and related disorders involving chloride ion dysregulation
Apexbio Technology LLC AS 101 106566-58-9 50mg
AS 101 (CAS 106566-58-9) chemically known as ammonium trichloro(dioxoethylene-O O -)tellurate is a non-toxic immunomodulatory small molecule that acts primarily by inhibiting interleukin-10 (IL-10) signaling In cell-based studies AS 101 reduces IL-10 production and suppresses mesangial cell proliferation in a dose-dependent manner It has been shown to decrease tyrosine phosphorylation and nuclear translocation of STAT3 correlating with inhibition of IL-10 activity AS 101 stimulates IL-2 secretion and enhances immune cell function in both human and murine models In animal studies systemic administration confers bone marrow-sparing effects during chemotherapy mitigates alopecia enhances survival in sepsis models and modulates cytokine production These properties support its utility in investigating immune regulation and potential therapeutic interventions targeting cytokine-mediated pathologies
Medchemexpress LLC AVN-101 hydrochlorid 25mg | 1061354-48-0 | 340.89 | C21H25ClN2 | 25 MG
AVN-101 hydrochloride is the hydrochloride salt of a brain-penetrant small molecule antagonist of serotonin (5-HT) receptors, supplied for preclinical and in-vitro research. It is provided as a solid with reported high purity for analytical and biological assays.
- Potent antagonist of 5-HT receptor subtypes (5-HT7, 5-HT6, 5-HT2A, 5-HT2C).
- High purity: 99.59%.
- Molecular formula C21H25ClN2; molecular weight 340.89.
- Available in small research pack sizes, including 25 MG.
- Provided as hydrochloride salt to improve solubility for assay preparation.
- For research use only; not for human or veterinary use.
![Medchemexpress LLC Tetradecanoic acid, 2,3-bis[(1-oxododecyl)oxy]propyl ester | 60175-30-6 | MFCD00063570 | 98.0% | 667.05 g/mol | C41H78O6 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000288249.png-250.jpg)
Medchemexpress LLC Tetradecanoic acid, 2,3-bis[(1-oxododecyl)oxy]propyl ester | 60175-30-6 | MFCD00063570 | 98.0% | 667.05 g/mol | C41H78O6 | 10 MG
1,2-Dilauroyl-3-myristoyl-rac-glycerol is a medium-chain triacylglycerol used as a research reagent and an intermediate for synthesizing functional edible oils and related lipid derivatives. It is typically supplied in small, research-scale quantities for laboratory studies.
- Medium-chain triacylglycerol suitable for lipid synthesis and formulation.
- High purity (98.0%) suitable for research applications.
- Chemical formula C41H78O6; molecular weight 667.05 g/mol.
- Appearance: white to off-white oil.
- Provided in small research-scale quantities (e.g., 10 mg).
Medchemexpress LLC Lauroyl-L-carnitine (chloride) | 6919-91-1 | 98.1% | 50 MG
Lauroyl-L-carnitine chloride is an orally active metabolite that exhibits anti-inflammatory effects and improves systemic and local phenotypes in TNBS mice. It significantly reverses the decrease in its target gene IL-10 and alleviates Crohn's-like colitis.
- Orally active metabolite
- Reverses decrease in target gene IL-10
- Exhibits anti-inflammatory effects
- Improves systemic and local phenotypes in TNBS mice
- Alleviates Crohn's-like colitis
Medchemexpress LLC Lauroyl-L-carnitine (chloride) | 6919-91-1 | MFCD00274131 | 98.1% | 379.96 g·mol⁻¹ | C19H38ClNO4 | 5 MG
Lauroyl-L-carnitine chloride is an acylcarnitine-derived absorption enhancer used in research to increase the oral bioavailability of peptide compounds. It is provided as a high-purity solid for laboratory use and can be prepared as solutions for experimental assays following recommended storage conditions.
- Orally active absorption enhancer for peptide compounds.
- Improves oral bioavailability of peptide therapeutics in preclinical studies.
- Supplied as a high-purity solid suitable for solution preparation.
- Available in small research pack sizes and larger quantities on request.
- Stable when stored sealed at 4°C; in solution store at -80°C (6 months) or -20°C (1 month).
- Molecular formula C19H38ClNO4; molecular weight 379.96 g·mol⁻¹.
![Medchemexpress LLC 7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide | 1012054-59-9 | MFCD15528940 | >98.0% | 434.49 g/mol | C24H26N4O4 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000247159.png-250.jpg)
Medchemexpress LLC 7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-N-hydroxyheptanamide | 1012054-59-9 | MFCD15528940 | >98.0% | 434.49 g/mol | C24H26N4O4 | 100 MG
CUDC-101 is a small-molecule research compound that concurrently inhibits histone deacetylases (HDACs) and receptor tyrosine kinases EGFR and HER2. It is used in preclinical cancer research to study combined epigenetic and kinase-targeted therapies.
- Potent inhibition of HDAC, EGFR, and HER2 with IC50s of 4.4 nM, 2.4 nM, and 15.7 nM.
- Contains a hydroxamic acid moiety associated with HDAC activity.
- High purity (>98.0%) suitable for research applications.
- Soluble in DMSO at 25 mg/mL (approximately 57.54 mM; may require ultrasonic agitation).
- Molecular formula C24H26N4O4 and molecular weight 434.49 g/mol.
Medchemexpress LLC Lauroyl-L-carnitine-d3 hydrochloride | 1297271-52-3 | C₁₉H₃₅D₃ClNO₄ | 2.5 MG
Lauroyl-L-carnitine-d3 (hydrochloride) is a deuterium labeled compound. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled compound
- Used as tracers for quantitation during drug development
- Potential to affect pharmacokinetic and metabolic profiles of drugs
- For research use only
Medchemexpress LLC ULK-101 100mg | 2443816-45-1 | 100 MG
ULK-101 is a potent and selective ULK1 inhibitor used in research to suppress autophagy and sensitize cancer cells to nutrient stress. It demonstrates high potency against ULK1 with reduced activity against ULK2.
- Selective ULK1 inhibition with IC50 ≈ 1.6 nM.
- Reduced activity against ULK2 (IC50 ≈ 30 nM).
- High chemical purity reported at 99.91%.
- Molecular formula C22H16F4N4OS and molecular weight 460.45.
- Supplied as a powder; common pack size 100 mg.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (2 years) or -20°C (1 year).