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Organic compounds that consist of five-membered heterocyclic molecules containing a nitrogen atom and at least one other non-carbon atom as part of the ring.
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JQ-1 carboxylic acid is a potent BET bromodomain inhibitor, derived from (+)-JQ-1. It is utilized for synthesizing PROTACs that target the degradation of BRD4. This compound is an off-white to yellow solid with a molecular weight of 400.88 and the chemical formula C19H17ClN4O2S.
Potent BET bromodomain inhibitor.
Used to synthesize PROTAC, targeting BRD4 degradation.
Soluble in DMSO (100 mg/mL).
Downregulates PD-L1 expression on B16F10 cells in vitro.
Applicable in various disease areas including cancer, and signaling pathways such as epigenetics and immunology/inflammation.
Store powder at -20°C for 3 years or 4°C for 2 years.
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2-Bromothiazole is a biochemical reagent used as a biological material or organic compound for life science related research. It is intended for research purposes only. It is also utilized as an Aryl halide for N-arylation of 5- and 7-azaindoles, and copper-catalyzed cyanation provides 2-cyanothiazole.
Used as a biochemical reagent
Applicable as a biological material or organic compound in life science research
Can be used as an Aryl halide
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YTX-465 is a research reagent that inhibits stearoyl-CoA desaturase (Ole1/SCD). It inhibits Ole1 (IC50 = 0.039 μM) and SCD1 (IC50 = 30.4 μM), and is supplied as high-purity material in solid form or as a DMSO solution for biochemical and cellular studies related to lipid metabolism and neurodegenerative disease research.
High purity (99.1%).
Inhibits Ole1 and SCD1 with reported IC50 values.
Available as solids and as DMSO solution for flexible dosing.
Provided with a product data sheet and a safety data sheet.
Molecular formula C25H26N6O3 and molecular weight 458.51 for reference.
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