Aminobenzoic acids and derivatives
Medchemexpress LLC Pritelivir mesylate | 1428333-96-3 | 99.5% | 498.60 g·mol⁻¹ | C19H22N4O6S3 | 10 MG
Pritelivir mesylate is the mesylate salt of pritelivir, a small-molecule inhibitor of the herpes simplex virus helicase-primase complex. It demonstrates potent antiviral activity in vitro against HSV-1 and HSV-2 (reported IC50 ≈ 0.02 μM) and is intended for research use in antiviral and virology studies.
- Inhibits the viral helicase-primase complex, reducing HSV replication.
- Potent in vitro activity with low-nanomolar IC50.
- High reported purity suitable for biochemical and cell-based assays.
- Supplied as a mesylate salt for improved stability and solubility handling.
- Available in small research quantities for preclinical experimentation.
Medchemexpress LLC Naquotinib mesylate | 1448237-05-5 | MFCD30496702 | 98.2% | 658.81 | C31H46N8O6S | 10 MG
Naquotinib mesylate is the mesylate salt of naquotinib, an orally available, irreversible, mutant-selective epidermal growth factor receptor (EGFR) inhibitor used in preclinical research. It preferentially inhibits common activating and resistance EGFR mutants while showing reduced potency against wild-type EGFR, making it useful for studies of mutant-selective signaling and resistance mechanisms.
- Mutant-selective irreversible EGFR inhibitor
- Potent against L858R, exon 19 deletion, and T790M mutants (IC50 8-33 nM)
- Lower potency toward wild-type EGFR (IC50 ~230 nM)
- Provided as a mesylate salt suitable for research applications
- Molecular formula C31H46N8O6S; molecular weight 658.81
- Reported research-grade purity approximately 98%
Medchemexpress LLC Naquotinib mesylate | 1448237-05-5 | 98.1% | 658.81 | 25 MG
Naquotinib mesylate (ASP8273 mesylate) is an orally available, mutant-selective, and irreversible EGFR inhibitor that demonstrates inhibitory concentrations (IC50s) ranging from 8 to 33 nM against EGFR mutants and 230 nM for wild-type EGFR. It effectively inhibits the growth of various EGFR-dependent non-small cell lung cancer cell lines, including those with exon 19 deletion and T790M resistance mutations. The compound selectively targets the phosphorylation of EGFR and its downstream signaling pathways, such as ERK and Akt, at concentrations as low as 10 nM in sensitive cell lines. Additionally, oral administration of this compound induces dose-dependent tumor regression in several xenograft models.
- Orally available
- Mutant-selective EGFR inhibitor
- Irreversible EGFR inhibitor
- Inhibits phosphorylation of EGFR and downstream signal pathway, ERK and Akt
- Induces tumor shrinkage in EGFR mutated tumor models
Medchemexpress LLC ERGi-USU-6 mesylate | 2756327-67-8 | 95.0% | 338.38 | 10 MM 1 ML
ERGi-USU-6 mesylate is an inhibitor of ERG and RIOK2, demonstrating anticancer activity against ERG-positive prostate cancer. It inhibits the growth of ERG positive VCaP cells with an IC50 value of 0.089 μM.
- Inhibits ERG and RIOK2 (IC50 values: 0.17 and 0.13 μM in VCaP cells).
- Exhibits anticancer activity against ERG-positive prostate cancer.
- Inhibits the growth of ERG positive VCaP cells (IC50 value: 0.089 μM).
Apexbio Technology LLC Dabrafenib Mesylate (GSK-2118436) 1195768-06-9 10mM (in 1mL DMSO)
Dabrafenib Mesylate (GSK-2118436 CAS 1195768-06-9) is a potent orally active inhibitor that specifically targets the mutant BRAF kinase variant V600E BRAF functions as a serine/threonine kinase essential in the MAPK/ERK signaling cascade frequently mutated in various human cancers Dabrafenib selectively inhibits BRAF V600E (IC50 0 8 nM) with lower activity against wild-type B-Raf and c-Raf By binding and disrupting BRAF V600E activity dabrafenib attenuates downstream MAPK/ERK activation leading to reduced cellular proliferation and tumorigenicity This agent is useful for investigating oncogenic pathways and was FDA-approved for metastatic melanoma with BRAF V600E mutation
![eMolecules 169869-90-3 | Exatecan (mesylate) | ChemScene | MFCD04113012 | 531.560 | C25H26FN3O7S | 98.000 | CS(O)(=O)=O.CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](N)c(c3Cn1c2=O)c45 | 100mg | 536818695](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000130509.jpg-250.jpg)
eMolecules 169869-90-3 | Exatecan (mesylate) | ChemScene | MFCD04113012 | 531.560 | C25H26FN3O7S | 98.000 | CS(O)(=O)=O.CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](N)c(c3Cn1c2=O)c45 | 100mg | 536818695
Exatecan (mesylate) | ChemScene | 169869-90-3 | MFCD04113012 | 531.560 | C25H26FN3O7S | 98.000 | CS(O)(=O)=O.CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](N)c(c3Cn1c2=O)c45 | 100mg | 536818695
Medchemexpress LLC PBT434 methanesulfonate | 2387898-69-1 | 99.9% | 1 MG
PBT434 mesylate (PBT434 methanesulfonate, ATH434) is a brain-penetrant, orally active small molecule inhibitor of α-synuclein aggregation with iron-chelating activity, supplied for research use in studies of synucleinopathies and neurodegeneration.
- Inhibits α-synuclein aggregation and reduces iron-mediated aggregation.
- Acts as an iron chelator and modulates iron trafficking.
- Brain-penetrant and orally active, suitable for in vivo studies.
- High purity appropriate for biochemical and cellular assays.
- Solid, white to off-white appearance; store sealed at 4°C.
![eMolecules 169869-90-3 | Exatecan (mesylate) | ChemScene | MFCD04113012 | 531.560 | C25H26FN3O7S | 98.000 | CS(O)(=O)=O.CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](N)c(c3Cn1c2=O)c45 | 250mg | 536818696](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000128313.jpg-250.jpg)
eMolecules 169869-90-3 | Exatecan (mesylate) | ChemScene | MFCD04113012 | 531.560 | C25H26FN3O7S | 98.000 | CS(O)(=O)=O.CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](N)c(c3Cn1c2=O)c45 | 250mg | 536818696
Exatecan (mesylate) | ChemScene | 169869-90-3 | MFCD04113012 | 531.560 | C25H26FN3O7S | 98.000 | CS(O)(=O)=O.CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](N)c(c3Cn1c2=O)c45 | 250mg | 536818696
Apexbio Technology LLC Saquinavir mesylate 149845-06-7 10mg
Saquinavir mesylate is a reversible inhibitor of HIV protease a retroviral aspartic protease required for viral maturation and replication It targets the active site of HIV-1 and HIV-2 proteases preventing enzymatic cleavage of polyprotein precursors thereby suppressing formation of mature viral particles Saquinavir inhibits HIV-1 protease with a reported Ki value of approximately 0 12 nM In cultured human neuronal cells it also reduces -amyloid (A 40) levels and inhibits -secretase (BACE1) activity at 50 M concentration it reduces neuronal A production by approximately 90% Saquinavir is commonly employed in HIV/AIDS research and has potential in Alzheimer s disease models for studying the modulation of amyloid peptide synthesis pathways
Medchemexpress LLC Pamufetinib mesylate | 1688673-09-7 | 99.2% | 614.66 g/mol | C28H27FN4O7S2 | 50MG
Pamufetinib mesylate is a research-grade small-molecule multi-kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR) and hepatocyte growth factor receptor (c-Met/HGFR). It exhibits potent activity in biochemical assays, with reported IC50 values near 30 nM for VEGFR2 and 32 nM for MET, and is intended for in vitro and preclinical research use only.
- High purity suitable for research (reported 99.17%).
- Potent VEGFR and c-Met inhibition (IC50 ~30-32 nM).
- Available as solid and DMSO solution formats for assay flexibility.
- Characterized molecular weight and formula for analytical work.
- Supplied in multiple pack sizes to support diverse study scales.
Chemscene m-Dibromobenzene | 25g | CS-W008980 | 98% | 108-36-1 | MFCD00000078 | 235 91 | C6H4Br2
Chemscene | m-Dibromobenzene | 25g | CS-W008980 | 98% | 108-36-1 | MFCD00000078 | 235 91 | C6H4Br2
Chemscene 1 4-Dibromo-2 5-dimethylbenzene | 500g | CS-W007702 | 98% | 1074-24-4 | MFCD00000091 | 263 96 | C8H8Br2
Chemscene | 1 4-Dibromo-2 5-dimethylbenzene | 500g | CS-W007702 | 98% | 1074-24-4 | MFCD00000091 | 263 96 | C8H8Br2
Chemscene 2-(Piperazin-1-yl)benzonitrile | 5g | CS-W016848 | 98% | 111373-03-6 | MFCD00040793 | 187 25 | C11H13N3
Chemscene | 2-(Piperazin-1-yl)benzonitrile | 5g | CS-W016848 | 98% | 111373-03-6 | MFCD00040793 | 187 25 | C11H13N3
Chemscene (R)-3-(Boc-amino)pyrrolidine | 5g | CS-W002421 | 98% | 122536-77-0 | MFCD00143191 | 186 25 | C9H18N2O2
Chemscene | (R)-3-(Boc-amino)pyrrolidine | 5g | CS-W002421 | 98% | 122536-77-0 | MFCD00143191 | 186 25 | C9H18N2O2