Anilides
Medchemexpress LLC Hydroxyphenyl Fluorescein (HPF) | 359010-69-8 | 99.9% | 424.40 | 1 MG
Hydroxyphenyl Fluorescein (HPF) is a stable Reactive Oxygen Species (ROS) fluorescent probe dye. It exhibits stronger specificity and stability compared to H2DCFDA. Hydroxyphenyl Fluorescein generates strong green fluorescence through a hydroxyl radical reaction with intracellular peroxynitroso. It can be utilized for fluorescence microscopy, high-throughput imagers, luciferase microplate readers, or flow cytometry. The excitation/emission wavelengths are 490/515 nm.
- Stable ROS fluorescent probe dye.
- Stronger specificity and stability than H2DCFDA.
- Produces strong green fluorescence via hydroxyl radical reaction with intracellular peroxynitroso.
- Applicable for fluorescence microscopy, high-throughput imager, luciferase microplate reader, or flow cytometry.
- Ex/Em=490/515 nm.
Medchemexpress LLC NAP-2/CXCL7 recombinant protein, mouse (His-tagged) | 121337-30-2 | >95.0% | 10 UG
Recombinant NAP-2/CXCL7 mouse protein, His-tagged, supplied lyophilized for research use. It is a 74-amino-acid chemokine (K40-Y113) produced in Escherichia coli and intended for in vitro studies of neutrophil chemotaxis and activation. Store frozen and reconstitute according to supplier instructions.
- Recombinant His-tagged mouse chemokine (74 amino acids).
- Produced in Escherichia coli expression system.
- Supplied lyophilized, 10 μg per vial.
- Purity greater than 95% by reducing SDS-PAGE.
- Predicted molecular mass ~10.4 kDa.
- Formulated with stabilizers for lyophilization.
- Suitable for in vitro chemotaxis and neutrophil activation assays.
- Store at -20°C; aliquot and freeze at -20°C or -80°C for long term.
Cayman Chemical LeflunomIde 500mg
A prodrug form of A-771726; inhibits de novo pyrimidine synthesis to regulate T lymphocyte progression through the cell cycle; inhibits proliferation and activation of T cells at 25 and 100 µM, respectively, for naïve and memory CD4+ T cells; reduces and prevents inflammation in a proteoglycan-induced mouse model of rheumatoid arthritis at 35 mg/kg per day
Medchemexpress LLC 1-Naphthalenamine, N,N-dimethyl- | 86-56-6 | 99.9% | 5 G
N,N-Dimethyl-1-naphthylamine is an aromatic amine and a dye that can be utilized in the nitrate reduction test.
- Aromatic amine.
- Functions as a dye.
- Can be used in nitrate reduction tests.
Grainger Disp Dspr Nap 3 1/2 in x6 3/4 in PK10000
The Grainger 16W476 is a heavy duty, high-visibility safety vest made by Ergodyne. It features 100% polyester fabric with 2" silver reflective tape to keep workers visible in low light conditions. The vest has a zipper front closure, V-neck design, and adjustable side straps for a secure fit. It meets ANSI/ISEA 107-2015 Class 2 standards for high visibility apparel. The 16W476 vest comes in sizes ranging from medium to 5XL.
Apexbio Technology LLC S-Nitroso-N-acetyl-DL-penicillamine 67776-06-1 50mg
S-Nitroso-N-acetyl-DL-penicillamine (SNAP CAS 67776-06-1) is a low-molecular-weight nitric oxide (NO) donor that facilitates the sustained release of NO in biological systems By elevating NO levels SNAP stimulates soluble guanylate cyclase activity resulting in increased cyclic guanosine monophosphate (cGMP) production and subsequent modulation of downstream signaling pathways These actions contribute to vascular smooth muscle relaxation and vasodilation SNAP is widely employed in experimental studies to investigate NO-mediated mechanisms including inhibition of platelet aggregation and regulation of inflammatory responses and serves as a valuable reagent for probing NO signaling in cultured cells
Apexbio Technology LLC Leflunomide 75706-12-6 10mM (in 1mL DMSO)
Leflunomide (CAS 75706-12-6) is a small-molecule agonist targeting the aryl hydrocarbon receptor (AHR) pathway It is designed to modulate AHR signaling thereby enhancing regulatory T cell (Treg) numbers altering inflammatory cytokine profiles and influencing immune responses Leflunomide exerts its biological activity primarily through metabolic conversion to its active metabolite Teriflunomide (A771726) which mediates immunosuppressive effects It enhances IL-10 production and suppresses IL-17 and IL-23 secretion In cell-based studies leflunomide demonstrates anti-proliferative efficacy in human medullary thyroid carcinoma cells (MTC-TT) with IC50 values ranging from approximately 30 to 50 M depending on specific assay conditions Based on these pharmacological properties leflunomide holds research potential in ischemia-reperfusion renal injury sepsis-induced intestinal oxidative stress and tumor proliferation inhibition models
Medchemexpress LLC Leflunomide | 75706-12-6 | 99.8% | C12H9F3N2O2 | 1 ML
Leflunomide is a pyrimidine synthesis inhibitor that acts by inhibiting dihydroorotate dehydrogenase (DHODH), functioning as a disease-modifying antirheumatic agent. It is an immunomodulatory drug that prevents the expansion of activated and autoimmune lymphocytes by interfering with cell cycle progression due to inadequate rUMP production and by utilizing mechanisms involving p53. This product is for research use only.
- Inhibits dihydroorotate dehydrogenase (DHODH)
- Functions as a disease-modifying antirheumatic agent
- Inhibits proliferation of mononuclear and T-cells
- Inhibits several protein tyrosine kinases
- Prevents expansion of activated and autoimmune lymphocytes
![Medchemexpress LLC N-[2-methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidin-1-yl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide | 1211866-85-1 | MFCD22123242 | 99.7% | 516.52 g/mol | C25H27F3N6O3 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000239943.png-250.jpg)
Medchemexpress LLC N-[2-methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidin-1-yl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide | 1211866-85-1 | MFCD22123242 | 99.7% | 516.52 g/mol | C25H27F3N6O3 | 25 MG
TC-N 1752 is a small-molecule research compound that inhibits Nav1.7 (voltage-gated sodium) channels and is used in pharmacology and electrophysiology studies of sodium channel function and pain signaling. The substance is identified by CAS 1211866-85-1, has molecular formula C25H27F3N6O3 and a molecular weight of about 516.5 g/mol. It is supplied as a solid with DMSO solubility and is accompanied by analytical data supporting its stated purity.
- Potent Nav1.7 inhibitory activity useful for sodium channel research.
- High reported purity suitable for biochemical assays.
- Characterized chemical identity with CAS and molecular formula available.
- Soluble in DMSO for preparation of experimental solutions.
- Available in multiple pack sizes to accommodate different study scales.