Benzenesulfonamides

Medchemexpress LLC 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide | 287403-39-8 | 99.6% | 398.50 | C17H22N2O5S2 | 10 MG

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TMI-1 is a small-molecule inhibitor of TNF-α converting enzyme (TACE/ADAM17) with activity against several ADAM and matrix metalloproteinase (MMP) family proteases. It has demonstrated antiproliferative and pro-apoptotic effects in cancer cell models and can suppress TNF-α secretion and inflammatory responses in preclinical studies. Supplied as a high-purity solid for research use.

• Inhibits TACE (ADAM17) and multiple MMPs with low-nanomolar potency.
• Demonstrates antiproliferative and apoptosis-inducing activity in cellular models.
• Reduces TNF-α secretion and inflammatory markers in preclinical studies.
• High purity solid suitable for biochemical and cellular assays.
• Available in small mass packs for research applications.

Medchemexpress LLC 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide | 287403-39-8 | 99.6% | 398.50 g/mol | C17H22N2O5S2 | 100 MG

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TMI-1 (WAY-171318) is a small-molecule inhibitor of TNF-α converting enzyme (TACE) with reported activity against ADAM-17, ADAMTS-4, and multiple MMPs. Supplied for research use, it has demonstrated oral activity and induces apoptosis in cancer cell models, and is provided with analytical documentation for laboratory studies.

• Purity 99.57%.
• Molecular formula C17H22N2O5S2.
• Molecular weight 398.50 g/mol.
• Available as solid (5 mg, 10 mg, 25 mg, 50 mg, 100 mg) and solution (10 mM in DMSO).
• Includes datasheet, COA, and SDS documentation.
• Suitable for biochemical, cell-based, and in vivo oral dosing research (research use only).

Medchemexpress LLC 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide | 287403-39-8 | 99.6% | 398.50 g/mol | C17H22N2O5S2 | 50 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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TMI-1 (WAY-171318) is a small-molecule research tool that potently inhibits TNF-α converting enzyme (TACE/ADAM17) and multiple matrix metalloproteinases, induces apoptosis via caspase-dependent pathways, and has demonstrated activity in cell-based assays and animal models of inflammation and cancer.

• Potent TACE inhibition (reported IC50 ≈ 8.4 nM)
• Induces apoptosis in cancer cell lines via caspase-dependent mechanisms
• Reduces TNF-α secretion and alleviates inflammatory symptoms in animal models
• Available as solid and solution forms for in vitro and in vivo use
• High purity suitable for research applications

eMolecules​ 4-Chloro-1-(phenylsulfonyl)-5-(trifluoromethyl)-1h-pyrrolo[2,3-b]pyridine-2-carboxylic acid | 1299607-39-8 | MFCD18803508 | 1g

Combi-Blocks | 4-Chloro-1-(phenylsulfonyl)-5-(trifluoromethyl)-1h-pyrrolo[2,3-b]pyridine-2-carboxylic acid | 1g | 401043950 | QB-9131 | 95.000 | 1299607-39-8 | MFCD18803508 | 404.740 | C15H8ClF3N2O4S

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1-(2-Mesitylenesulfonyl)imidazole 97.0+%, TCI America™

CAS: 50257-39-1 Molecular Formula: C12H14N2O2S Molecular Weight (g/mol): 250.32 MDL Number: MFCD00005284 InChI Key: XFHVQSPNDDOABS-UHFFFAOYSA-N Synonym: 1-mesitylsulfonyl-1h-imidazole,1-2-mesitylenesulfonyl imidazole,n-mesitylenesulfonyl imidazole,n-mesitylenesulfonylimidazole,1-2,4,6-trimethylbenzenesulfonyl imidazole,1-2,4,6-trimethylphenyl sulphonyl-1h-imidazole,1h-imidazole, 1-2,4,6-trimethylphenyl sulfonyl,2,4,6-trimethylphenyl sulfonyl imidazole,acmc-209kkw,mesitylenesulfonylimidazole PubChem CID: 99556 IUPAC Name: 1-(2,4,6-trimethylbenzenesulfonyl)-1H-imidazole SMILES: CC1=CC(C)=C(C(C)=C1)S(=O)(=O)N1C=CN=C1