Benzophenones
Apexbio Technology LLC Mebendazole 31431-39-7 25g
Mebendazole (CAS 31431-39-7) is a small-molecule inhibitor targeting tubulin It is designed to disrupt microtubule polymerization thereby impairing cellular structural integrity in parasites and tumor cells Mebendazole exerts its biological activity primarily by binding to tubulin and inhibiting microtubule assembly In cell-based studies mebendazole demonstrates activity against Giardia isolates with a 24-h IC50 of 0 19 M and induces apoptosis in melanoma cell lines (average IC50 0 32 mol/L) associated with Bcl-2 phosphorylation and mitochondrial pathway activation In lung cancer cellular studies mebendazole induces G2-M arrest prior to apoptosis in vivo it suppresses growth of lung cancer xenografts in mice Based on these pharmacological properties mebendazole holds research potential in parasitic infections melanoma and lung cancer
Medchemexpress LLC Oxybenzone | 131-57-7 | 99.9% | C14H12O3 | 500 MG
Oxybenzone (Benzophenone 3) is a widely used UV filter found in sun tans and skin protectants. It functions as an endocrine-disrupting chemical (EDC) and is capable of crossing both placental and blood-brain barriers. Research indicates that this compound impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.
- Acts as a UV filter in sunscreens and skin protectants
- Functions as an endocrine disrupting chemical (EDC)
- Capable of crossing both placental and blood-brain barriers
- Impairs autophagy
- Alters epigenetic status
- Disrupts retinoid X receptor signaling in apoptotic neuronal cells
- For research use only
Apexbio Technology LLC Nepafenac 78281-72-8 25mg
Nepafenac (CAS 78281-72-8) is a small-molecule inhibitor targeting cyclooxygenase enzymes COX-1 and COX-2 It is designed to inhibit these enzymes thereby reducing prostaglandin E2 (PGE2) biosynthesis and modulating ocular inflammatory pathways Nepafenac exerts its biological activity primarily through COX-1 and COX-2 inhibition In cell-based studies nepafenac demonstrates inhibitory activity with IC50 values of approximately 250 nM for COX-1 and 150 nM for COX-2 In LPS-induced inflammation models topical application reduces retinal PGE2 concentrations Additionally it has been studied as an inhibitor of cellular proliferation in human uveal melanoma cell lines (SP6 5 92 1 OCM-1 MKT-BR UW-1) Based on these pharmacological properties nepafenac holds research potential in ophthalmologic studies involving inflammatory pathways and ocular malignancies
Medchemexpress LLC Fenofibric acid | 42017-89-0 | 99.9% | 500 MG
Fenofibric acid is an active metabolite of fenofibrate and acts as a PPAR activator. It has EC50 values of 22.4 μM for PPARα, 1.47 μM for PPARγ, and 1.06 μM for PPARδ. It also inhibits COX-2 enzyme activity with an IC50 of 48 nM. This product is for research use only.
- Inhibits COX-2 enzyme dose-dependently with an IC50 of 48 nM.
- Reduces abundance of AOX1 protein in HepG2 cells at 500 nM.
- Decreases JNK1/2, c-Jun, and p38 MAPK phosphorylation at 100 μM.
- Prevents reactive oxygen species accumulation, ER stress, and blood retinal barrier disruption.
- Activates IGF-IR/Akt/ERK1/2-mediated survival signaling pathways.
- Demonstrates anti-inflammatory activity in Wistar rats at doses of 1, 5, 10 mg/kg (p.o.).