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Filtered Search Results
Selleck Chemical LLC acalisib
Acalisib (GS-9820 CAL-120) is a highly selective and potent p110 inhibitor (IC50 14 nM) with 114- to 400-fold selectivity over the other class I PI3K enzymes and no activity against Class II and III PI3K family members or other PI3K-related proteins including mTOR and DNA-PK
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Chemscene ChemScene | 2-(2,3,6-Trifluorophenyl)acetic acid | 5G | CS-W015908 | 0.97 | 114152-23-7| MFCD00061217 | 190.12
ChemScene | 2-(2,3,6-Trifluorophenyl)acetic acid | 5G | CS-W015908 | 0.97 | 114152-23-7| MFCD00061217 | 190.12
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eMolecules 53209-19-1 | 4-Nitro-1,2-phenylenediamine monohydrochloride | Combi-Blocks | MFCD00043273 | 189.600 | C6H8ClN3O2 | 95.000 | Cl.Nc1ccc(cc1N)[N+]([O-])=O | 5g | 495746633
4-Nitro-1,2-phenylenediamine monohydrochloride | Combi-Blocks | 53209-19-1 | MFCD00043273 | 189.600 | C6H8ClN3O2 | 95.000 | Cl.Nc1ccc(cc1N)[N+]([O-])=O | 5g | 495746633
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Medchemexpress LLC 1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]- | 2259624-71-8 | 98.3% | 490.88 | 100 MG
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STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM. It exhibits excellent pan-polymorph activity across a panel of STING proteins in HEK293T cells, specifically 92%, 107%, and 92% against R232, H232, and HAQ, respectively. Notably, it is not active at mouse STING. In vivo, the compound is well-absorbed with a short terminal half-life.
- Potent, orally active human STING activator
- Shows excellent pan-polymorph activity across STING proteins in HEK293T cells
- Not active at mouse STING
- Well-absorbed with a short terminal half-life in vivo
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eMolecules 582323-16-8 | Medchem Express | ICA-069673 | 5mg | 446256746 | HY-101396 | MFCD20926351 | 269.64 | C11H6ClF2N3O
Medchem Express | ICA-069673 | 5mg | 446256746 | HY-101396 | 582323-16-8 | MFCD20926351 | 269.640 | C11H6ClF2N3O
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eMolecules 135748-33-3 | 2,4-Dichloro-5-fluorobenzamide | Apollo Scientific | MFCD01631478 | 208.010 | C7H4Cl2FNO | 97.000 | NC(=O)c1cc(F)c(Cl)cc1Cl | 10g | 562455253
2,4-Dichloro-5-fluorobenzamide | Apollo Scientific | 135748-33-3 | MFCD01631478 | 208.010 | C7H4Cl2FNO | 97.000 | NC(=O)c1cc(F)c(Cl)cc1Cl | 10g | 562455253
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eMolecules 1143502-70-8 | AstaTech | 3-BROMO-45-DIFLUOROBENZALDEHYDE | 0.25g | 302797714 | CL9630 | 95 | MFCD22056748 | 221.001 | C7H3BrF2O
ChemScene | 5-Ethynyl-1H-pyrazolo[34-b]pyridine | 100mg | 712836116 | CS-0371726 | 1207351-15-2 | MFCD22187975 | 143.149 | C8H5N3
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Medchemexpress LLC Ds45500853 | 2735803-28-6 | 99.2% | 284.35 g·mol⁻1 | C18H20O3 | 5 MG
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DS45500853 is a small-molecule agonist of estrogen-related receptor alpha (ERRα) used in preclinical research to investigate metabolic pathways and disorders such as type 2 diabetes. It inhibits the interaction between RIP140 corepressor peptide and the ERRα ligand-binding domain with reported activity in the submicromolar to micromolar range and is supplied as a high-purity research compound.
- Agonist of estrogen-related receptor alpha (ERRα).
- Inhibits RIP140-ERRα corepressor binding with reported activity (IC50 ~0.80 μM).
- High purity suitable for biochemical and cellular assays.
- Soluble in DMSO for typical assay preparations.
- Available in small milligram quantities for preclinical studies.
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Medchemexpress LLC Ccr2 antagonist 3 | 1380100-86-6 | 99.9% | 308.39 g·mol⁻1 | C17H25FN2O2 | 100 MG
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CCR2 antagonist 3 is a small-molecule chemokine receptor 2 (CCR2) antagonist supplied for laboratory research. It is intended for in vitro and cellular studies to probe CCR2-mediated signaling and inflammation pathways. For research use only; not for human or clinical use.
- High purity (99.9%) suitable for biochemical and cell-based assays.
- Molecular weight 308.39 g·mol⁻1 and formula C17H25FN2O2.
- Available as solid quantities and as a 10 mM solution in DMSO for convenient dosing.
- Recommended storage conditions provided to preserve compound stability.
- Useful tool compound for studying CCR2-related inflammatory responses.
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Selleck Chemical LLC Bulleyaconi cine A S3907-25mg
Bulleyaconi cine A (Bulleyaconitine A BLA) is an active ingredient of Aconitum bulleyanum plants and classified as an aconitine-like alkaloid It is a potent use-dependent blocker for both Nav1 7 and Nav1 8 Na currents
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eMolecules 918505-61-0 | Medchem Express | BRAF inhibitor | 10mg | 446257766 | HY-10247 | MFCD16659048 | 456.47 | C22H18F2N4O3S
Medchem Express | BRAF inhibitor | 10mg | 446257766 | HY-10247 | 918505-61-0 | MFCD16659048 | 456.470 | C22H18F2N4O3S
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eMolecules 1883431-67-1 | OF-02 (solution in ethanol) | Broadpharm1314.162 | C84H152N4O6 | 0.000 | CCCCC\C=C/C\C=C/CCCCCCC(O)CN(CCCCC1NC(=O)C(CCCCN(CC(O)CCCCCC\C=C/C\C=C/CCCCC)CC(O)CCCCCC\C=C/C\C=C/CCCCC)NC1=O)CC(O)CCCCCC\C=C/C\C=C/CCCCC | 5mg | 779524078
OF-02 (solution in ethanol) | Broadpharm | 1883431-67-11314.162 | C84H152N4O6 | 0.000 | CCCCC\C=C/C\C=C/CCCCCCC(O)CN(CCCCC1NC(=O)C(CCCCN(CC(O)CCCCCC\C=C/C\C=C/CCCCC)CC(O)CCCCCC\C=C/C\C=C/CCCCC)NC1=O)CC(O)CCCCCC\C=C/C\C=C/CCCCC | 5mg | 779524078
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Enzo Life Sciences Rucaparib phosphate (10mg). CAS: 459868-92-9
Rucaparib is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
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Enzo Life Sciences A1874 (10mg). CAS: 2064292-12-0
A1874 is a nutlin-based PROTAC targeting on BRD4, consist of a BRD4-ligand JQ1 linked to a MDM2 E3 ligase ligand RG7388. A1874 possesses dual function as it dose-dependently degraded its target BRD4, accompanied with the downregulation of c-MYC, as well as stabilization of P53 and upregulated P21 due to the efficient engagement of MDM2 by RG7388. Purity: ≥98%. Long Term Storage: -20°C.
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eMolecules 1315449-72-9 | Medchem Express | Osilodrostat (phosphate) | 5mg | 752823256 | HY-16276A | 325.236 | C13H13FN3O4P
ChemScene | tert-Butyl (5-amino-3-methylpyridin-2-yl)carbamate | 100mg | 788448995 | CS-0637392 | 1566524-62-6 | MFCD26032867 | 223.276 | C11H17N3O2
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