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N-phenylureas

Organic compounds that consist of a urea molecule with a phenyl functional group substitution on one of the two nitrogen atoms on the urea molecule.

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1

Medchemexpress LLC Urea, N-(2-bromophenyl)-N'-[2-[ethyl(3-methylphenyl)amino]ethyl]- | 459429-39-1 | 99.1% | 376.29 | 100 MG
SDP

SB 452533 is a potent and selective TRPV1 antagonist with a pKb of 7.8. It is intended for research use only.

  • Acts as a potent antagonist at the cloned recombinant rat TRPV1 receptor in HEK293 cells, with a pKb of 7.7 and a pIC50 of 7.0.
  • Reduces the phosphorylation of CAMKK2 and AMPK in skeletal muscle (C2C12) cells.
  • Abolishes Capsaicin's effect of reducing Bleomycin-induced pulmonary fibrosis in BALB/c mice.

ENCOMPASS_PREFERRED
2

Medchemexpress LLC SB-265610 | 211096-49-0 | 98.98% | C14H9BrN6O | 50 MG
SDP

SB-265610 is a selective, competitive, nonpeptide, and allosteric CXCR2 antagonist. It blocks rat CINC-1-induced calcium mobilization (IC50 of 3.7 nM) and neutrophil chemotaxis (IC50 of 70 nM). In animal models, it significantly inhibits Gr-1+CD11b+ cell recruitment to mammary adenocarcinoma.

  • Selective, competitive, nonpeptide, and allosteric CXCR2 antagonist.
  • Blocks rat CINC-1-induced calcium mobilization (IC50 of 3.7 nM).
  • Blocks neutrophil chemotaxis (IC50 of 70 nM).
  • Reduces CINC-1's antiapoptotic effect.
  • Inhibits Gr-1+CD11b+ cell recruitment to mammary adenocarcinoma in animal models.

ENCOMPASS_PREFERRED
3

Medchemexpress LLC SB 452533 | 459429-39-1 | 99.1% | 376.29 | 1 ML
SDP

SB 452533 is a potent and selective TRPV1 antagonist with a pKb of 7.8. It is for research use only and not sold to patients.

  • Potent antagonist at the cloned recombinant rat TRPV1 receptor in HEK293 cells.
  • Reduces phosphorylation of CAMKK2 and AMPK.
  • Abolishes the effects of small dose Capsaicin in reducing Bleomycin-induced pulmonary fibrosis in mice.

ENCOMPASS_PREFERRED
4

Medchemexpress LLC SB 452533 | 459429-39-1 | 99.11% | 376.29 | 50 MG
SDP

SB 452533 is a potent and selective TRPV1 antagonist with a pKb of 7.8. It functions by acting as a potent antagonist at the cloned recombinant rat TRPV1 receptor in HEK293 cells. This compound has been shown to reduce phosphorylation of CAMKK2 and AMPK, and to abolish the effects of Capsaicin in reducing Bleomycin-induced pulmonary fibrosis in mice.

  • Potent and selective TRPV1 antagonist
  • Reduces phosphorylation of CAMKK2 and AMPK
  • Abolishes the effects of capsaicin in reducing bleomycin-induced pulmonary fibrosis in mice

ENCOMPASS_PREFERRED