Phenylhydrazines
Medchemexpress LLC Bendamustine (hydrochloride) | 3543-75-7 | 99.89% | C16H22Cl3N3O2 | 100 MG
Bendamustine hydrochloride is a purine analogue and a DNA cross-linking agent that activates DNA-damage stress response and apoptosis. It possesses potent alkylating, anticancer, and antimetabolite properties.
- A purine analogue.
- Acts as a DNA cross-linking agent.
- Activates DNA-damage stress response.
- Induces apoptosis.
- Exhibits potent alkylating properties.
- Demonstrates anticancer effects.
- Possesses antimetabolite characteristics.
- Induces p21 (Cip1/Waf1) and NOXA genes.
- Increases the expression of p53 in SU-DHL-1 cells.
- Blocks mitotic checkpoints and causes mitotic catastrophe.
- Reduces the viability of multiple myeloma cell lines.
- Induces specific caspase-dependent multiple myeloma cell death.
- Inhibits the spindle-assembly checkpoint.
Medchemexpress LLC Almonertinib (hydrochloride) | 2134096-03-8 | 98.9% | 562.11 | 50 MG
Almonertinib hydrochloride is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor. It exhibits high selectivity for EGFR-sensitizing and T790M resistance mutations and is utilized in non-small cell lung cancer research. It can also inhibit other EGFR sensitive mutations, including G719X, del19, L858R, and L861Q.
- Orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor
- High selectivity for EGFR-sensitizing and T790M resistance mutations
- Potent inhibitory activity against T790M (IC50: 0.37 nM), T790M/L858R (IC50: 0.29 nM), and T790M/Del19 (IC50: 0.21 nM)
- Less effective against wild-type EGFR (IC50: 3.39 nM)
- Used for research in non-small cell lung cancer (NSCLC)
- Inhibits other EGFR sensitive mutations such as G719X, del19, L858R, and L861Q
Medchemexpress LLC Itacnosertib hydrochloride (TP-0184 hydrochloride) | 2409543-84-4 | 99.4% | 505.01 | 1 ML
Itacnosertib hydrochloride (TP-0184 hydrochloride) is an inhibitor for FLT3, ACVR1 (ALK2, IC50=8 nM), and JAK2 (IC50=8540 nM) that exhibits anti-leukemic activity.
- Inhibits FLT3, ACVR1 (ALK2), and JAK2.
- Exhibits anti-leukemic activity.
- Arrests the cell cycle of MOLM-13, MOLM-14, and MV4-11 at G1/G0 phase.
- Inhibits the proliferation of acute myeloid leukemia (AML) cells.
- Inhibits the activation of FLT3 and ACVR1 downstream signaling pathways.
- Inhibits serine biosynthesis and amino acid transport pathways.
- Exhibits antitumor activity against MOLM-13 in mouse models.
Medchemexpress LLC Omadacycline hydrochloride | 1196800-39-1 | 99.47% | 593.11 | 1 ML
Omadacycline hydrochloride | 1196800-39-1 | 99.47% | 593.11 | 1 ML
Medchemexpress LLC Neticonazole hydrochloride | 130773-02-3 | 99.9% | 1 ML
Neticonazole hydrochloride is an imidazole derivative that acts as a potent and long-acting antifungal agent, also exhibiting anti-infection and anti-cancer effects. In vitro, it decreases Alix, Rab27a, and nSMase2 levels, and inhibits p-ERK. It demonstrates potent, dose-dependent inhibition of exosome release from C4-2B cells, functioning as an orally active exosome biogenesis and secretion inhibitor. In vivo, it improved survival in intestinal dysbacteriosis mice with colorectal cancer xenograft tumors by increasing apoptosis.
- Potent and long-acting antifungal agent
- Exhibits anti-infection and anti-cancer effects
- Decreases Alix, Rab27a, and nSMase2 levels
- Inhibits p-ERK levels
- Potent exosome release inhibitor
- Orally active exosome biogenesis and secretion inhibitor
- Improves survival in colorectal cancer xenograft models
Aobchem Ethyl 2-(3-fluoro-5-methylphenyl)-2-oxoacetate | ≥95% | CAS 951888-58-7 | C11H11FO3 | 10g
Ethyl 2-(3-fluoro-5-methylphenyl)-2-oxoacetate | ≥95% | CAS 951888-58-7 | C11H11FO3 | 10g
Aobchem Ethyl 2-(4-chloro-3-methylphenyl)-2-oxoacetate | ≥95% | CAS 250642-57-0 | C11H11ClO3 | 10g
Ethyl 2-(4-chloro-3-methylphenyl)-2-oxoacetate | ≥95% | CAS 250642-57-0 | C11H11ClO3 | 10g
Aobchem 3 5-Difluorophenylhydrazine hydrochloride | ≥97% | CAS 502496-27-7 | C6H7ClF2N2 | 100g
3 5-Difluorophenylhydrazine hydrochloride | ≥97% | CAS 502496-27-7 | C6H7ClF2N2 | 100g
Aobchem (5-Bromo-2-fluoro-3-methylphenyl)(cyclohexyl)methanol | 95% | CAS 2969443-60-3 | C14H18BrFO | 5g
(5-Bromo-2-fluoro-3-methylphenyl)(cyclohexyl)methanol | 95% | CAS 2969443-60-3 | C14H18BrFO | 5g
Aobchem (3-Bromo-2-formyl-5-methylphenyl)boronic acid | 97% | C8H8BBrO3 | 5g
(3-Bromo-2-formyl-5-methylphenyl)boronic acid | 97% | C8H8BBrO3 | 5g
Aobchem (6-Bromo-2-fluoro-3-methylphenyl)(m-tolyl)methanol | 97% | CAS 3002520-50-2 | C15H14BrFO | 1g
(6-Bromo-2-fluoro-3-methylphenyl)(m-tolyl)methanol | 97% | CAS 3002520-50-2 | C15H14BrFO | 1g
Aobchem 2-Chloro-5-fluoro-4-methylphenylboronic acid | ≥97% | CAS 1612184-35-6 | C7H7BClFO2 | 250mg
2-Chloro-5-fluoro-4-methylphenylboronic acid | ≥97% | CAS 1612184-35-6 | C7H7BClFO2 | 250mg
Accela Chembio Inc 4-cyanophenylhydrazine Hydrochloride | 25g | 2863-98-1 | MFCD00673994 | 97+% | Shelf Life: 1800 Days | Moisture Sensitive
4-cyanophenylhydrazine Hydrochloride | 25g | 2863-98-1 | MFCD00673994 | 97+% | Shelf Life: 1800 Days | Moisture Sensitive
Aobchem 2-Chloro-5-fluoro-4-methylphenol | 97% | CAS 1803588-57-9 | C7H6ClFO | 250mg
2-Chloro-5-fluoro-4-methylphenol | 97% | CAS 1803588-57-9 | C7H6ClFO | 250mg
Aobchem 4-Chloro-2-fluoro-5-methylphenylboronic acid pinacol ester | ≥97% | CAS 1126320-27-1 | C13H17BClFO2 | 500mg
4-Chloro-2-fluoro-5-methylphenylboronic acid pinacol ester | ≥97% | CAS 1126320-27-1 | C13H17BClFO2 | 500mg