Phenylhydrazines
Sigma Aldrich (1-Isopropyl-1H-imidazol-5-yl)methanol hydrochloride
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Medchemexpress LLC JBSNF-000028 hydrochloride | C11H14ClN3 | 25 MG
JBSNF-000028 hydrochloride is an orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT). It demonstrates anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model, suitable for research into metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
- Orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT)
- Reduces endogenous MNA levels in U2OS osteosarcoma cells with an EC50 of 2.5 μM
- Exhibits anti-obesity and anti-diabetic activities in diet-induced obesity (DIO) model
- Useful for studying metabolic diseases (obesity, type 2 diabetes, non-alcoholic fatty liver disease)
- IC50 values for NNMT: 33 nM (human), 210 nM (mouse), 190 nM (monkey)
Medchemexpress LLC JBSNF-000028 hydrochloride | C11H14ClN3 | 10 MM * 1 ML
JBSNF-000028 hydrochloride is an orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT). It shows anti-obesity and anti-diabetic activities and can be used for the study of metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
- Orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT)
- Reduces endogenous MNA levels in U2OS osteosarcoma cells
- Shows significant anti-obesity and anti-diabetic activities
- Used for the study of metabolic diseases
- Improves glucose and lipid handling in mice with diet-induced obesity (DIO)
- Improves glucose tolerance in NNMT knockout mice with diet-induced obesity
Medchemexpress LLC 2-Methyl-1,2,5,6-tetrahydro-3H-pyrrolo[3,2,1-ij]quinazolin-3-imine hydrochloride | C11H14ClN3 | 5 MG
JBSNF-000028 hydrochloride is an orally active, small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values of 33 nM for human NNMT. It effectively reduces endogenous MNA levels in U2OS osteosarcoma cells with an EC50 of 2.5 μM. This compound has demonstrated significant anti-obesity and anti-diabetic activities in diet-induced obesity models.
- Inhibits NNMT activity with an EC50 of 2.5 μM in U2OS cells
- Shows no cytotoxicity against HepG2 cells at 10-100 μM
- Improves glucose and lipid handling in mice with diet-induced obesity
- Improves glucose tolerance in NNMT knockout mice with diet-induced obesity
- Used for studying metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease
Medchemexpress LLC JBSNF-000028 hydrochloride | C11H14ClN3 | 100 MG
JBSNF-000028 hydrochloride is an orally active small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT), with IC50 values for human, mouse, and monkey NNMT of 33, 210, and 190 nM, respectively. It reduces endogenous MNA levels in U2OS cells (EC50 2.5 μM) and shows significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. It is suitable for studying metabolic diseases like obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
- Inhibits NNMT activity in U2OS cells (EC50 2.5 μM).
- Shows no cytotoxicity against HepG2 cells at 10-100 μM.
- Binds below a hairpin structural motif at the nicotinamide pocket.
- Inactive against a broad panel of metabolism-related targets.
- Improves glucose and lipid handling in mice with diet-induced obesity.
- Enhances glucose tolerance in NNMT knockout DIO mice.