BAY 11-7082 (BAY 11-7821) is a NF-?B inhibitor, inhibits TNF?-induced I?B? phosphorylation with IC50 of 10 ?M in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 ?M and 0.96 ?M, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells. *For Research & Development use only. Product is not intended for drug, household, or human consumption.