Trifluoromethylbenzenes
Medchemexpress LLC Flutamide | 13311-84-7 | 99.9% | C11H11F3N2O3 | 500 MG
Flutamide is an Androgen Receptor antagonist with a Ki of 55 nM. It inhibits prostate cancer progression and has shown potential in protecting against hyperthermia-induced multiple organ dysfunction syndrome. The active metabolite, Flutamide-OH, directly binds to the rat anterior pituitary androgen receptor. Flutamide has cytotoxic activity against PC3 and LNCap cells, inducing apoptosis and reducing cell migration and colonization. It downregulates the expression of KLK2 and EMT pathway genes in cells.
- Androgen receptor antagonist
- Inhibits prostate cancer progression
- Protects against hyperthermia-induced multiple organ dysfunction syndrome
- Exhibits cytotoxic activity against PC3 and LNCap cells
- Induces apoptosis and reduces cell migration
- Downregulates KLK2 and EMT pathway genes
- Significantly reduces rat ventral prostate weight in vivo
Medchemexpress LLC Adenosine, N-benzoyl-, cyclic 3',5'-(hydrogen phosphate), sodium salt | 1135306-29-4 | 98.5% | 455.29 | C17H15N5NaO7P | 1 MG
6-Bnz-cAMP sodium salt is a cell-permeable cyclic AMP (cAMP) analog that selectively activates cAMP-dependent protein kinase A (PKA) without activating Epac-mediated signaling. It is supplied as the sodium salt solid for use in cell-based and biochemical assays to probe PKA-specific responses.
- Cell-permeable cAMP analog for cellular and biochemical studies.
- Selectively activates PKA but not Epac signaling pathways.
- High purity (98.5%), suitable for sensitive assays.
- Molecular weight approximately 455.29 g/mol.
- Solid sodium salt form for enhanced solubility and handling.
- Store sealed, away from moisture; recommended -20°C. In solvent: -80°C up to 6 months, -20°C up to 1 month.
Apexbio Technology LLC Ivacaftor benzenesulfonate 1134822-09-5 25mg
Ivacaftor benzenesulfonate (CAS 1134822-09-5) is a small molecule modulator of the cystic fibrosis transmembrane conductance regulator (CFTR) protein It acts as a potentiator enhancing CFTR channel open probability and facilitating chloride ion transport in cells carrying gating (G551D) or processing (F508del) mutations In vitro ivacaftor benzenesulfonate demonstrates IC50 values of 25 nM for F508del-CFTR and 100 nM for G551D-CFTR mutations and increases chloride secretion in human cystic fibrosis bronchial epithelial cells This compound is valuable in studies of CFTR function and in the investigation of therapeutic approaches for cystic fibrosis-related mutations
Apexbio Technology LLC Ivacaftor benzenesulfonate 1134822-09-5 100mg
Ivacaftor benzenesulfonate (CAS 1134822-09-5) is a small molecule modulator of the cystic fibrosis transmembrane conductance regulator (CFTR) protein It acts as a potentiator enhancing CFTR channel open probability and facilitating chloride ion transport in cells carrying gating (G551D) or processing (F508del) mutations In vitro ivacaftor benzenesulfonate demonstrates IC50 values of 25 nM for F508del-CFTR and 100 nM for G551D-CFTR mutations and increases chloride secretion in human cystic fibrosis bronchial epithelial cells This compound is valuable in studies of CFTR function and in the investigation of therapeutic approaches for cystic fibrosis-related mutations
Apexbio Technology LLC 6-Bnz-cAMP sodium salt(Synonyms: N6-Benzoyl-cAMP sodium salt, 6-Benzoyladenosine-3',5'-cyclic monophosphate sodium salt), 5mg, CAS: 1135306-29-4.
6-Bnz-cAMP sodium salt (CAS 1135306-29-4) is a selective cAMP analogue that functions as an activator of protein kinase A (PKA)-dependent signaling pathways It specifically targets the conserved cAMP-binding domains on PKA triggering downstream phosphorylation events Activation of PKA subsequently impacts signaling proteins such as CREB whose phosphorylation state mediates processes like osteoblast differentiation Experimental studies indicate 6-Bnz-cAMP promotes differentiation mineralization and early cell adhesion notably it drives osteogenic differentiation in MC3T3-E1 cells Its potential for controlled release further suggests utility as a molecule for regenerative strategies in bone tissue engineering
Apexbio Technology LLC 6-Bnz-cAMP sodium salt(Synonyms: N6-Benzoyl-cAMP sodium salt, 6-Benzoyladenosine-3',5'-cyclic monophosphate sodium salt), 10mg, CAS: 1135306-29-4.
6-Bnz-cAMP sodium salt (CAS 1135306-29-4) is a selective cAMP analogue that functions as an activator of protein kinase A (PKA)-dependent signaling pathways It specifically targets the conserved cAMP-binding domains on PKA triggering downstream phosphorylation events Activation of PKA subsequently impacts signaling proteins such as CREB whose phosphorylation state mediates processes like osteoblast differentiation Experimental studies indicate 6-Bnz-cAMP promotes differentiation mineralization and early cell adhesion notably it drives osteogenic differentiation in MC3T3-E1 cells Its potential for controlled release further suggests utility as a molecule for regenerative strategies in bone tissue engineering