Aminophenols
![Medchemexpress LLC 2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid hydrochloride | 200006-08-2 | MFCD09971056 | 98.2% | 429.91 | C24H25ClFNO3 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000239773.png-250.jpg)
Medchemexpress LLC 2-[[(3R)-3-(4-fluorophenyl)-3-(4-phenylphenoxy)propyl]-methylamino]acetic acid hydrochloride | 200006-08-2 | MFCD09971056 | 98.2% | 429.91 | C24H25ClFNO3 | 1 MG
ALX-5407 hydrochloride is the hydrochloride salt of a selective glycine transporter 1 (GlyT1) inhibitor used in preclinical research to increase extracellular glycine and probe GlyT1 biology. It is provided as a high-purity research chemical for in vitro and in vivo studies.
- Selective glycine transporter 1 inhibitor with high potency (IC50 ≈ 3 nM).
- Hydrochloride salt form for improved solubility.
- High purity (98.2%) suitable for research applications.
- Available in small quantities for dose-response and pilot studies.
- Molecular weight 429.91 and formula C24H25ClFNO3 for precise calculations.
Medchemexpress LLC Afm-30a hydrochloride | 99.8% | 502.97 | 50 MG
AFM-30a hydrochloride is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor with an EC50 value of 9.5 μM for PAD2. It also inhibits H3 citrullination with an EC50 value of 0.4 μM. This compound is intended for research related to certain cancers and various autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis. It exhibits low cytotoxicity in HEK293T/PAD2 cells and can suppress NLRP3 signaling and decrease airway remodeling in PAD2-/- transgenic mice.
- Potent protein arginine deiminase 2 (PAD2) inhibitor.
- Excellent PAD2-selectivity.
- Inhibits H3 citrullination.
- Can be used for research of certain cancers and autoimmune diseases (rheumatoid arthritis, multiple sclerosis, lupus, ulcerative colitis).
- Low cytotoxicity in HEK293T/PAD2 cells.
- Suppresses NLRP3 signaling and decreases airway remodeling in PAD2-/- transgenic mice.
Medchemexpress LLC RGX-104 hydrochloride | 610318-03-1 | 99.9% | 632.54 | 10 MG
RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity through the transcriptional activation of the ApoE gene. It is intended for research use only.
- Modulates innate immunity via transcriptional activation of the ApoE gene.
- Potential anti-cancer activity through suppression of various cancer types, including lung cancer, melanoma, glioblastoma, ovarian, renal cell, triple-negative breast, and colon cancer.
- Induces tumor regression in some cases.
- Available in various quantities.
Medchemexpress LLC L-NAME (hydrochloride) | 51298-62-5 | 99.9% | 269.69 | 5 G
L-NAME hydrochloride is an inhibitor of nitric oxide synthase (NOS) with an IC50 of 70 μM. It acts as a precursor to the NOS inhibitor L-NOARG, which has an IC50 value of 1.4 μM. It is used for research purposes only and is not sold to patients.
- Inhibits NOS with an IC50 of 70 μM.
- Precursor to the more potent NOS inhibitor L-NOARG (IC50 = 1.4 μM).
- Can be used to induce hypertension models in animals.
- Can be used to induce preeclampsia models in animals.
Medchemexpress LLC SKI-178 | 1259484-97-3 | 99.3% | 50 MG
SKI-178 is a potent inhibitor of both sphingosine kinase-1 (SphK1) and sphingosine kinase-2 (SphK2). It demonstrates cytotoxicity in various cancer cell lines, including agent-sensitive and multi-agent resistant types, with IC50 concentrations ranging from 0.1 to 1.8 μM. This compound has been shown to induce apoptosis in human acute myeloid leukemia cell lines in a CDK1-dependent manner and correlates with prolonged Bcl-2 phosphorylation. In in-vivo studies, SKI-178 inhibited leukemic progression in the MLL-AF9 mouse model, leading to a decrease in white blood cell counts.
- Potent SphK1 and SphK2 inhibitor
- Exhibits cytotoxicity in various cancer cell lines
- Induces apoptosis in human acute myeloid leukemia cells
- Correlates with prolonged Bcl-2 phosphorylation
- Inhibits leukemic progression in MLL-AF9 mouse model
Medchemexpress LLC Harmane hydrochloride | 21655-84-5 | 99.4% | 218.68 g/mol | C12H11ClN2 | 5 MG
Harmane hydrochloride is the hydrochloride salt of a β-carboline alkaloid used in neuropharmacology research. It modulates imidazoline receptors and monoamine oxidase and is supplied as a high-purity analytical reagent for assays, receptor profiling, and mechanistic studies.
- High purity (99.35%) suitable for analytical use.
- Molecular formula C12H11ClN2 and molecular weight 218.68 g/mol.
- Provided in small vials for assay and analytical workflows.
- Active compound for studies of imidazoline receptors and MAO-related pathways.
- Certificate of analysis and safety data sheet available for quality and safety information.
Medchemexpress LLC Zilpaterol-d7 | 1217818-36-4 | C14H12D7N3O2 | 1 MG
Zilpaterol-d7 is a deuterium Zilpaterol. Zilpaterol is a β-adrenergic agonist that has been widely used to feed cattle.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC R 59-022 (hydrochloride) | 93076-98-3 | MFCD34676749 | 98.9% | 496.04 | C27H27ClFN3OS | 5 MG
R 59-022 (hydrochloride) is a research-grade small-molecule inhibitor used to probe diacylglycerol kinase (DGK) activity and downstream lipid signaling pathways in biochemical and cellular studies. The compound is supplied as a hydrochloride salt with reported molecular weight 496.04 and high analytical purity appropriate for laboratory research applications.
- Selective diacylglycerol kinase inhibitor activity.
- Potentiates protein kinase C activation in cellular assays.
- High purity suitable for biochemical and cell-based studies.
- Supplied as a hydrochloride salt to aid solubility in polar solvents.
- Provided in small research pack sizes for laboratory use.
Medchemexpress LLC Guvacine hydrochloride | 6027-91-4 | MFCD00055191 | 99.9% | 163.60 g/mol | C6H10ClNO2 | 25 MG
Guvacine hydrochloride is the hydrochloride salt of guvacine, a pyridine alkaloid that acts as a GABA uptake inhibitor. Supplied as a high-purity research reagent, it is used in biochemical and neuropharmacological studies to probe GABA transporter activity. The substance is intended for laboratory research use only and is not for human or veterinary use.
- High purity (99.93%) for reliable experimental results.
- Molecular weight 163.60 g/mol.
- Molecular formula C6H10ClNO2.
- CAS number 6027-91-4 for unambiguous identification.
- Available in multiple pack sizes and solution formats for flexible use.
- Suitable for in vitro biochemical and pharmacology research.
Medchemexpress LLC RS100329 hydrochloride | 1215654-26-4 | 99.6% | 462.89 g/mol | C20H26ClF3N4O3 | 25 MG
RS100329 hydrochloride is the hydrochloride salt of RS100329, a potent and selective α1A-adrenoceptor antagonist used in pharmacological research, including studies of urethral reflex contractions and benign prostatic hyperplasia. It is supplied as a solid research chemical with high reported purity and defined storage recommendations.
- Potent, selective α1A-adrenoceptor antagonist (pKi 9.6 for α1A).
- High purity (≈99.6% by HPLC), suitable for biochemical assays.
- Well-characterized small molecule: molecular weight 462.89 g/mol, formula C20H26ClF3N4O3.
- Provided as a solid hydrochloride salt for accurate dosing in experiments.
- Recommended storage: 4°C protected from light; in solvent, -80°C (6 months) or -20°C (1 month).
eMolecules 86347-15-1 | Medetomidine Hydrochloride | Key Organics/BIONET236.740 | C13H17ClN2 | 99.000 | Cl.CC(c1cnc[nH]1)c1cccc(C)c1C | 40mg | 564356423
Medetomidine Hydrochloride | Key Organics/BIONET | 86347-15-1236.740 | C13H17ClN2 | 99.000 | Cl.CC(c1cnc[nH]1)c1cccc(C)c1C | 40mg | 564356423
Medchemexpress LLC Bi-9627 (hydrochloride) | 1422252-46-7 | 98.01% | 392.80 | 1 ML
BI-9627 hydrochloride is a potent inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1), exhibiting high selectivity over NHE2 and no measurable activity against NHE3. This compound shows low agent-agent interaction potential, excellent pharmacokinetics, and potent activity in isolated heart models of ischemia-reperfusion injury. It is intended for research use only.
- Decreases autophagy in HTR-8/SVneo cells.
- Significantly reduces the pHi of human sperm and partially reverses the effect of DMA.
- Prolongs Ca2+ recovery time in KO hiPSC-CMs.
- Shows low DDI potential.
- Excellent pharmacokinetics in rat and dog.
- Potent activity in isolated heart models of ischemia-reperfusion injury.
Medchemexpress LLC His-pro (hydrochloride) | 2415727-78-3 | 99.8% | 288.73 | 10 MG
His-Pro hydrochloride, also known as Histidyl-proline hydrochloride, is a dipeptide composed of histidyl and proline. This compound is commonly used in laboratory research.
- Dipeptide
- Solid appearance
- White to off-white color
Medchemexpress LLC AZD9056 hydrochloride | 345303-91-5 | MFCD30533694 | 98.2% | 455.46 | 1 ML
AZD9056 hydrochloride is a selective, orally active inhibitor of P2X7, a receptor involved in inflammation and pain-causing diseases. It is for research use only.
- Selectively inhibits P2X7 receptors.
- Exhibits pain-relieving and anti-inflammatory effects.
- Blocks P2X7 receptors with an IC50 of 11.2 nM in HEK-hP2X7 cell line.
- Shows inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells.
- Reverses upregulated expression of IL-1β, IL-6, TNF-α, MMP-13, SP, and PGE2 induced by MIA in cartilage tissues.
- Investigated in clinical trials for conditions like rheumatoid arthritis.