Aminophenols
Medchemexpress LLC dTAGV-1 hydrochloride | 2624313-16-0 | 99.9% | C68H91ClN6O14S | 1 MG
dTAGV-1 hydrochloride is a potent and selective PROTAC degrader designed for FKBP12F36V-tagged proteins. This compound is capable of inducing the degradation of FKBP12F36V-Nluc both in vitro and in vivo, offering a valuable tool for targeted protein degradation research.
- Potent and selective degrader of FKBP12F36V-tagged proteins
- Induces degradation of FKBP12F36V-Nluc in vivo
- Composed of a Target Protein Ligand, Linker, and VHL Ligand
- Shows potent degradation of FKBP12F36V-Nluc in 293FT cells with no effects on FKBP12WT-Nluc
Medchemexpress LLC YIL781 hydrochloride | 1640226-17-0 | 99.5% | 445.96 g/mol | C24H29ClFN3O2 | 5 MG
YIL781 hydrochloride is the hydrochloride salt of a potent, orally active ghrelin receptor (GHSR) antagonist used in preclinical research to study ghrelin signaling, metabolic regulation, and insulin secretion. The compound is provided with solubility guidance and storage recommendations for reliable use in experimental workflows.
- Potent ghrelin receptor (GHSR) antagonist suitable for pharmacological studies.
- Usable in vitro and in vivo applications.
- High purity (~99.5%) for reliable experimental results.
- Soluble in DMSO; formulation guidance provided for aqueous preparations.
- Stable when stored sealed at -20°C; solvent stability recommendations available.
- Available in small research pack sizes for early-stage studies.
Medchemexpress LLC GSK 690 Hydrochlorid 25mg | 2436760-79-9 | 405.92 | C24H24ClN3O | 25 MG
GSK 690 hydrochloride is a reversible inhibitor of lysine-specific demethylase 1 (LSD1) used as a research reagent in biochemical and cellular studies. It exhibits low nanomolar binding and biochemical potency and is supplied as a small-scale package for laboratory use.
- Reversible LSD1 inhibitor with Kd 9 nM and biochemical IC50 37 nM.
- High chemical purity (98.6%) for in vitro applications.
- Well characterized molecular properties (MW 405.92 g/mol, formula C24H24ClN3O).
- Intended for biochemical and cellular research use.
Medchemexpress LLC CWI1-2 hydrochloride | 2408590-37-2 | C22H18Cl4N6O3 | 100 MG
CWI1-2 hydrochloride | 2408590-37-2 | C22H18Cl4N6O3 | 100 MG
Medchemexpress LLC CX-6258 hydrochloride hydrate | 1353858-99-7 | 99.2% | 516.42 | 1 ML
CX-6258 hydrochloride hydrate is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively.
- Potent and kinase selective pan-Pim kinases inhibitor
- IC50s of 5 nM (Pim-1), 25 nM (Pim-2), 16 nM (Pim-3)
- Causes dose-dependent inhibition of the phosphorylation of pro-survival proteins Bad and 4E-BP1 at specific Pim kinase sites (S112, S65, T37/46)
- Diminishes steady-state levels and reduces half-life of ectopic NKX3.1 in PC3 cells
- Exhibits robust in vivo efficacy in two Pim kinases driven tumor models (e.g., MV-4-11 xenograft models in nude mice)
Medchemexpress LLC RGX-104 hydrochloride | 610318-03-1 | 99.9% | 632.54 | 25 MG
RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene. This compound is for research use only and not sold to patients. Studies show it significantly suppresses the growth of multiple cancer types in animals, even in large tumors, with instances of partial or complete tumor regression.
- Acts as a small-molecule LXR agonist
- Modulates innate immunity through ApoE gene activation
- Significantly suppresses various cancer types in animal models
- Effective against large tumors, with potential for regression
- Applicable across a wide spectrum of malignancies
Medchemexpress LLC CSRM617 hydrochloride | 1353749-74-2 | 100.0% | 5MG
CSRM617 hydrochloride | 1353749-74-2 | 100.0% | 5MG
Medchemexpress LLC 4-Piperidinecarboxamide, N-hydroxy-1-(2-methoxyethyl)-4-[[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-, hydrochloride (1:1) | 226395-93-3 | 99.4% | 554.96 | 10 MG
SD-2590 hydrochloride is a potent MMP inhibitor with IC50 values of <0.1, <0.1, 0.18, and 1.7 nM for MMP2, MMP13, MMP9, and MMP8, respectively. It inhibits dilation of the left ventricle in rats. This product is for research use only.
- Potent MMP inhibitor
- Inhibits dilation of the left ventricle in rats
- Solid appearance
- White to off-white color
- Ships at room temperature
- Store at -20°C, sealed, away from moisture
- Soluble in DMSO at 55.5 mg/mL
Medchemexpress LLC Tacrine hydrochloride | 1684-40-8 | 99.9% | 1 ML
Tacrine hydrochloride is a potent brain-penetrant inhibitor of both AChE and BChE. It also acts as an NMDAR inhibitor. This compound can be utilized in research related to Alzheimer's disease.
- Potent brain-penetrant inhibitor of AChE and BChE.
- NMDAR inhibitor.
- Used for Alzheimer's disease research.
- Appearance: Solid, white to light yellow.
- Shipping: Room temperature in continental US.
- Storage: 4°C, stored under nitrogen, away from moisture.
- In solvent storage: -80°C for 6 months; -20°C for 1 month (stored under nitrogen, away from moisture).
- Solubility in H2O: 33.33 mg/mL (141.99 mM; needs ultrasonic).
Medchemexpress LLC RS 67333 hydrochloride | 168986-60-5 | 99.7% | 389.36 g/mol | C19H30Cl2N2O2 | 50 MG
RS 67333 hydrochloride is the hydrochloride salt of a selective partial agonist of the 5-HT4 (serotonin) receptor. Supplied as a solid research reagent, it is used in neuroscience studies of 5-HT4 receptor pharmacology, neuroprotection, and related pathways. For research use only.
- Selective partial agonist of 5-HT4 receptor.
- High purity (99.7%).
- Supplied as a solid suitable for in vitro and in vivo studies.
- Stable when stored sealed at 4°C, away from moisture.
- Available in small laboratory quantities for research applications.
Medchemexpress LLC AT7519 Hydrochloride | 902135-91-5 | 98.6% | C16H18Cl3N5O2 | 25 MG
AT7519 Hydrochloride is a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively. It is for research use only.
- Potent inhibitor of CDKs.
- Induces dose-dependent cytotoxicity and apoptosis in multiple myeloma cells.
- Inhibits cell cycle progression and induces apoptosis in human tumor cell lines.
- Inhibits transcription and RNA polymerase II in leukemia cell lines.
- Inhibits tumor growth in human xenograft mouse models.
- Investigated in clinical trials for various cancers.
Medchemexpress LLC CBB1007 hydrochloride | 2070014-96-7 | C27H39Cl5N8O4 | 50 MG
CBB1007 hydrochloride is a reversible and selective LSD1 inhibitor. It significantly blocks the demethylase activity of LSD1 on H3K4Me2 and H3K4Me, showing selectivity for LSD1 over LSD2 or JARID1A. This compound induces differentiation-related genes in pluripotent cells and is studied in non-pluripotent cancer research, targeting teratocarcinoma, embryonic carcinoma, and seminoma.
- Reversible and selective LSD1 inhibitor
- Blocks demethylase activity of LSD1 on H3K4Me2 and H3K4Me
- Induces differentiation-related genes in pluripotent cells
- Targeted in non-pluripotent cancer research
Medchemexpress LLC CWI1-2 hydrochloride | 2408590-37-2 | C22H18Cl4N6O3 | 25 MG
CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts. It induces apoptosis and differentiation, and demonstrates promising anti-leukemic effects. It is intended for research use only.
- Binds IGF2BP2
- Inhibits interaction with m6A-modified target transcripts
- Induces apoptosis
- Induces differentiation
- Demonstrates anti-leukemic effects
- For research use only
Medchemexpress LLC AC-099 hydrochloride | 849335-07-5 | C9H9Cl2F3N4 | 50 MG
AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). It has been shown to attenuate spinal nerve ligation-induced hypersensitivity in rats. This product is for research use only.
- Storage for powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- Appearance: Solid, white to off-white
- Purity: 99.92%
- Molecular weight: 301.10
Medchemexpress LLC MRT-83 (hydrochloride) | 1359944-60-7 | 99.6% | 575.05 | 25 MG
MRT-83 (hydrochloride) is a potent antagonist of the Smoothened (Smo) receptor. It inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has potential for researching cancer disease.
- Potent antagonist of Smoothened (Smo) receptor.
- Inhibits the Hedgehog (Hh) signaling pathway.
- Inhibits BODIPY-cyclopamine binding to human Smo.
- Potential for researching cancer disease.