Aminophenols
Medchemexpress LLC Imiloxan hydrochloride | 81167-22-8 | MFCD01074788 | >98.0% | 280.75 | C14H17ClN2O2 | 25 MG
Imiloxan hydrochloride is the hydrochloride salt of imiloxan, a potent and selective α2B-adrenoceptor antagonist used in pharmacology research. Supplied as a solid reagent, it is intended for distinguishing α2 receptor subtypes and for probing adrenergic signaling in both in vitro and in vivo studies.
- Potent, selective α2B-adrenoceptor antagonist for receptor pharmacology.
- Suitable for both in vitro and in vivo pharmacodynamic studies.
- High purity (≥98% HPLC) supporting reproducible results.
- Hydrochloride salt form improves aqueous solubility for dosing.
- Available in small research pack sizes appropriate for screening and dosing.
- Molecular formula C14H17ClN2O2; molecular weight 280.75 g/mol.
Medchemexpress LLC Rhosin hydrochloride | 1281870-42-5 | 99.9% | 394.86 | 100 MG
Rhosin hydrochloride is a potent and specific inhibitor of the RhoA subfamily of Rho GTPases. It specifically binds to RhoA to inhibit RhoA-GEF interaction and does not interact with Cdc42 or Rac1. This compound induces cell apoptosis and promotes stress resiliency by enhancing D1-MSN plasticity and reducing hyperexcitability.
- Potent and specific RhoA subfamily Rho GTPases inhibitor
- Induces cell apoptosis
- Promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability
- Dose-dependently reduces RhoA and p-MLC1 activities of mammospheres
- Decreases size and reduces number of mammospheres in cells
- Prevents social avoidance and blocks sucrose preference deficits in mice
- Attenuates stress-induced social avoidance
- Blocks stress-induced hyperexcitability in NAc dopamine 1 receptor medium spiny neurons (D1-MSNs)
Medchemexpress LLC AC-099 hydrochloride | 849335-07-5 | C9H9Cl2F3N4 | 50 MG
AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). It has been shown to attenuate spinal nerve ligation-induced hypersensitivity in rats. This product is for research use only.
- Storage for powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- Appearance: Solid, white to off-white
- Purity: 99.92%
- Molecular weight: 301.10
Medchemexpress LLC AM-92016 hydrochloride | 133229-11-5 | MFCD00673947 | 99.3% | 483.84 | C19H25Cl3N2O4S | 1 ML
AM-92016 hydrochloride is a small-molecule blocker of delayed rectifier potassium currents (IK), commonly used in electrophysiology and cardiovascular research to modulate action potential duration. It is supplied both as a solid and as a ready-to-use solution to support in vitro pharmacology and ion-channel assays.
- Blocks delayed rectifier potassium channels (IK) and shortens action potential duration.
- Supplied as a 10 mM solution in DMSO or as a dry solid for custom preparation.
- High purity suitable for research use (reported ~99.3%).
- Molecular weight 483.84 and CAS 133229-11-5 for clear identification.
- Available in small-quantity formats compatible with pharmacological assays.
Medchemexpress LLC RS 67333 hydrochloride | 168986-60-5 | 99.7% | 389.36 g/mol | C19H30Cl2N2O2 | 50 MG
RS 67333 hydrochloride is the hydrochloride salt of a selective partial agonist of the 5-HT4 (serotonin) receptor. Supplied as a solid research reagent, it is used in neuroscience studies of 5-HT4 receptor pharmacology, neuroprotection, and related pathways. For research use only.
- Selective partial agonist of 5-HT4 receptor.
- High purity (99.7%).
- Supplied as a solid suitable for in vitro and in vivo studies.
- Stable when stored sealed at 4°C, away from moisture.
- Available in small laboratory quantities for research applications.
Medchemexpress LLC Sotorasib-d7 | 2296729-00-3 | 98.9% | 567.64 | 10 MG
Sotorasib-d7 is a deuterium-labeled Sotorasib and a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. It irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state, leading to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Deuterium-labeled Sotorasib.
- First-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor.
- Irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state.
- Leads to the regression of KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Hlcl-61 hydrochloride | 1158279-20-9 | MFCD09446681 | 99.9% | 380.91 g·mol⁻¹ | C23H25ClN2O | 100 MG
HLCL-61 hydrochloride is a research-grade small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5), intended for in vitro and preclinical studies. It is supplied with analytical data and handling guidance and is not for human or clinical use.
- Potent and selective PRMT5 inhibition for cellular studies.
- High chemical purity suitable for research applications.
- Available in multiple pack sizes and ready-to-use DMSO solutions.
- Supplied with supporting datasheet and analytical information.
- Intended for controlled laboratory use with recommended storage conditions.
Medchemexpress LLC Rhosin hydrochloride | 1281870-42-5 | 99.94% | 394.86 | 1 ML
Rhosin hydrochloride is a potent and specific inhibitor of the RhoA subfamily Rho GTPases. It works by binding to RhoA, inhibiting its interaction with GEF proteins. This compound does not interact with Cdc42, Rac1, or LARG. It promotes stress resiliency and induces cell apoptosis, making it suitable for various research applications.
- Specifically inhibits RhoA subfamily Rho GTPases
- Induces cell apoptosis
- Promotes stress resiliency by enhancing D1-MSN plasticity
- Reduces hyperexcitability
- Does not interact with Cdc42, Rac1, or LARG
Medchemexpress LLC LY294002 (hydrochloride) | 934389-88-5 | 99.9% | 369.8 g/mol | C19H17NO3·HCl | 5 MG
LY294002 hydrochloride is the hydrochloride salt of LY294002, a cell-permeable small-molecule inhibitor of phosphoinositide 3-kinase (PI3K) and casein kinase 2 (CK2) used in in vitro studies of cell signaling, apoptosis, and autophagy. Supplied for research use with supporting documentation.
- Inhibits PI3K and CK2 signaling pathways.
- Suitable for in vitro cell signaling and apoptosis research.
- High purity (99.9%).
- Chemical formula C19H17NO3·HCl; molecular weight 369.8 g/mol.
- Supplied in small research quantities (e.g., 5 mg).
- Comes with SDS and certificate of analysis.
Medchemexpress LLC FTI-277 hydrochloride | 180977-34-8 | 98.0% | 484.07 | 5 MG
FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase). It is a highly potent Ras CAAX peptidomimetic that antagonizes both H- and K-Ras oncogenic signaling and can inhibit hepatitis delta virus (HDV) infection.
- Inhibits farnesyl transferase (FTase)
- Antagonizes H- and K-Ras oncogenic signaling
- Can inhibit hepatitis delta virus (HDV) infection
- Significantly decreases survival of radioresistant cells expressing the 24-kDa isoform
- Stimulates postmitotic cell death in HeLa 3A cells
- Reduces G(2)/M-phase arrest in both cell types (HeLa 3A and HeLa PINA)
- Inhibits migration and invasion in PC-3 cells
- Prevents increased PTP-1B and PTEN protein expression in burned mice