Aminophenols
Medchemexpress LLC AP14145 hydrochloride | 2387505-59-9 | 98.3% | 5 MG
AP14145 hydrochloride is a hydrochloride salt of a small-molecule negative allosteric modulator of KCa2 (SK) channels. It shows in vitro potency near 1.1 μM for KCa2.2 (SK2) and KCa2.3 (SK3) and has demonstrated prolongation of atrial effective refractory period and antiarrhythmic effects in preclinical models. Supplied as a 5 MG vial with reported purity of 98.3%.
- Negative allosteric modulator of KCa2 (SK) channels
- In vitro potency around 1.1 μM for SK2 and SK3
- Demonstrated atrial electrophysiology effects in vivo
- Hydrochloride salt form for improved handling
- High reported purity (98.3%)
Medchemexpress LLC R 59-022 (hydrochloride) | 93076-98-3 | MFCD34676749 | 98.9% | 496.04 | C27H27ClFN3OS | 5 MG
R 59-022 (hydrochloride) is a research-grade small-molecule inhibitor used to probe diacylglycerol kinase (DGK) activity and downstream lipid signaling pathways in biochemical and cellular studies. The compound is supplied as a hydrochloride salt with reported molecular weight 496.04 and high analytical purity appropriate for laboratory research applications.
- Selective diacylglycerol kinase inhibitor activity.
- Potentiates protein kinase C activation in cellular assays.
- High purity suitable for biochemical and cell-based studies.
- Supplied as a hydrochloride salt to aid solubility in polar solvents.
- Provided in small research pack sizes for laboratory use.
Medchemexpress LLC R 59-022 hydrochlori 10mg | 93076-98-3 | 10MG
R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC50 2 8 M) R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA R 59-022 hydrochloride is a 5-HT Receptor antagonist and activates protein kinase C (PKC) R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils[1 [2 [3 [4
Medchemexpress LLC R 59-022 (hydrochloride) | 93076-98-3 | MFCD34676749 | 98.9% | 496.04 g·mol⁻¹ | C27H27ClFN3OS | 50 MG
R 59-022 hydrochloride is the hydrochloride salt of R 59-022, a research compound that acts as a diacylglycerol kinase (DGK) inhibitor (reported IC50 ≈ 2.8 μM). It is used in cellular and biochemical assays to modulate diacylglycerol/protein kinase C signaling and to probe 5-HT receptor-related pathways. The material is supplied as an off-white solid (CAS 93076-98-3) with formula C27H27ClFN3OS and molecular weight 496.04 g·mol⁻¹.
- DGK inhibitor with reported IC50 ≈ 2.8 μM.
- Modulates protein kinase C and diacylglycerol signaling in cells.
- Hydrochloride salt form for improved handling and solubility in polar solvents.
- High purity suitable for research applications.
- Soluble in DMSO for preparation of stock solutions.