Aminophenols
Medchemexpress LLC Zzw-115 hydrochloride | 10122-45-9 | 98.1 % | 573.97 | 5 MG
ZZW-115 hydrochloride is a potent NUPR1 inhibitor with a Kd of 2.1 μM. It induces tumor cell death through necroptosis and apoptosis, demonstrating anticancer activity. It is efficient in killing various cancer cells with IC50 values ranging from 0.42 μM to 4.93 μM. This compound also induces a decrease in ATP production and a ROS overproduction.
- Efficient in killing cancer cells with IC50 values ranging from 0.42 μM to 7.75 μM
- Induces tumor cell death via necroptosis and apoptosis
- Decreases ATP production and induces ROS overproduction
- Inhibits the growth of pancreatic xenografted tumors in vivo
- Demonstrates potent anticancer activity
Medchemexpress LLC CX-6258 (hydrochloride) | 1353859-00-3 | 99.0% | 498.40 | 1 ML
CX-6258 hydrochloride is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively. It is for research use only and not sold to patients.
- Potent and kinase selective pan-Pim kinases inhibitor
- Inhibits Pim-1 with an IC50 of 5 nM, Pim-2 with an IC50 of 25 nM, and Pim-3 with an IC50 of 16 nM
- Causes dose-dependent inhibition of the phosphorylation of pro-survival proteins Bad and 4E-BP1 at specific Pim kinase sites (S112, S65, T37/46)
- Diminishes steady-state levels of ectopic NKX3.1 in PC3 cells and reduces NKX3.1 half-life
- Exhibits robust in vivo efficacy in two Pim kinases driven tumor models, with 50 mg/kg producing 45% tumor growth inhibition (TGI) and 100 mg/kg producing 75% TGI
Medchemexpress LLC CX-6258 hydrochloride hydrate | 1353858-99-7 | 99.2% | 516.42 | 25 MG
CX-6258 hydrochloride hydrate is a potent and selective pan-Pim kinases inhibitor. It effectively inhibits Pim-1, Pim-2, and Pim-3, making it suitable for research into cancer and metabolic diseases.
- Potent and kinase selective pan-Pim kinases inhibitor
- Inhibits Pim-1 (IC50: 5 nM), Pim-2 (IC50: 25 nM), and Pim-3 (IC50: 16 nM)
- Causes dose-dependent inhibition of phosphorylation of pro-survival proteins, Bad and 4E-BP1
- Diminishes steady-state levels of ectopic NKX3.1 in PC3 cells
- Exhibits robust in vivo efficacy in Pim kinases driven tumor models
- Achieves 45% tumor growth inhibition at 50 mg/kg and 75% at 100 mg/kg in vivo
Medchemexpress LLC CX-6258 hydrochloride | 1353859-00-3 | 99.0% | 498.40 | 50 MG
CX-6258 hydrochloride is a potent and kinase-selective pan-Pim kinases inhibitor, demonstrating IC50s of 5 nM for Pim-1, 25 nM for Pim-2, and 16 nM for Pim-3.
- Causes dose-dependent inhibition of the phosphorylation of pro-survival proteins, bad and 4e-bp1, at specific pim kinase sites.
- Treatment diminishes steady-state levels of ectopic nkx3.1 in pc3 cells.
- Treatment results in a significant reduction in nkx3.1 half-life.
- Exhibits robust in vivo efficacy in two pim kinase-driven tumor models.
- Demonstrates dose-dependent efficacy, producing 45% tumor growth inhibition at 50 mg/kg and 75% tumor growth inhibition at 100 mg/kg.
Medchemexpress LLC CX-6258 hydrochloride hydrate | 1353858-99-7 | 99.23% | 516.42 | 100 MG
CX-6258 hydrochloride hydrate is a potent and kinase-selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM, and 16 nM for Pim-1, Pim-2, and Pim-3, respectively. It is intended for research use only and not for sale to patients.
- Potent and kinase selective pan-Pim kinases inhibitor.
- Inhibits the phosphorylation of pro-survival proteins Bad and 4E-BP1 at specific Pim kinase sites (S112, S65, and T37/46 respectively).
- Diminishes steady-state levels of ectopic NKX3.1 in PC3 cells.
- Reduces NKX3.1 half-life.
- Exhibits robust in vivo efficacy in two Pim kinases driven tumor models, showing dose-dependent tumor growth inhibition (TGI) of 45% at 50 mg/kg and 75% at 100 mg/kg in MV-4-11 xenograft models in nude mice.