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Filtered Search Results
Apexbio Technology LLC Clomipramine HCl 17321-77-6 10mM (in 1mL DMSO)
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Clomipramine hydrochloride (CAS 17321-77-6) is a tricyclic compound that inhibits monoamine transporters acting as a potent blocker of the serotonin transporter (SERT Ki 0 14 nM) with additional inhibitory activity at the dopamine (DAT Ki 3 nM) and norepinephrine (NET Ki 54 nM) transporters By impeding the reuptake of these neurotransmitters clomipramine HCl modulates synaptic concentrations and neurotransmission This compound is utilized in neuropharmacological research to investigate monoaminergic signaling transporter pharmacology and the molecular mechanisms underlying psychiatric and neurological disorders
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Medchemexpress LLC Ethylenediaminetetraacetic acid disodium dihydrate | 6381-92-6 | MFCD00150037 | 99.9% | 372.24 g/mol | C10H18N2Na2O10 | 25g
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Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations including calcium) Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial anti-inflammatory antioxidant anti-hypercalcemia and anticoagulant activities Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins and allows maintenance of reducing environment during protein purification Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research[1][2][3][4][5][6][7]
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Medchemexpress LLC N-hydroxyisonicotinamidine | 1594-57-6 | MFCD00125873 | 99.9% | 137.14 g/mol | C6H7N3O | 5 G
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N-hydroxyisonicotinamidine is an amidoxime-based collector and chemical intermediate used in organic synthesis. It is commonly employed as a precursor in the preparation of substituted α-1,2,4-oxadiazole esters and related heterocycles. Supplied for research use only, consult the product datasheet for handling and storage details.
- Amidoxime-based collector for organic synthesis.
- Useful precursor for substituted α-1,2,4-oxadiazole esters.
- Molecular formula C6H7N3O; molecular weight 137.14 g/mol.
- Stable as a powder under low-temperature storage; follow datasheet storage conditions.
- For research use only; not validated for clinical or therapeutic use.
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Medchemexpress LLC Betacellulin/BTC Mo 5ug
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Probetacellulin Protein Mouse induces differentiation of pancreatic -cells and promotes regeneration of -cells in experimental diabetes
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Medchemexpress LLC Clopyralid | 1702-17-6 | MFCD00078655 | 98.5% | 192.00 | C6H3Cl2NO2 | 100 G
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Clopyralid is a selective pyridine-carboxylic herbicide (CAS 1702-17-6) supplied as a research-grade chemical for study and formulation development. It is used to control broadleaf weeds, including thistles and clovers, and is noted for its persistence in soils; users should follow handling and safety guidance in the SDS.
- Selective control of broadleaf weeds.
- High purity suitable for research (98.5%).
- Defined chemical identity: C6H3Cl2NO2, MW 192.00.
- Available in multiple laboratory pack sizes.
- Documentation available including SDS, COA, and datasheet.
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Apexbio Technology LLC Sodium Monofluorophosphate 10163-15-2 10mM (in 1mL H20)
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Sodium Monofluorophosphate is a small-molecule inhibitor targeting enzymes including pyruvate kinase alkaline phosphatase and phosphorylase phosphatase It is designed to competitively and irreversibly inhibit these enzymes thereby modulating enzyme-mediated phosphorylation processes and impacting glycogen metabolism pathways Sodium Monofluorophosphate exerts its biological activity primarily through competitive inhibition of pyruvate kinase and alkaline phosphatase by interfering with endogenous phosphate substrates and irreversible inhibition of phosphorylase phosphatase Based on these pharmacological properties Sodium Monofluorophosphate holds research potential in the study of enzymatic mechanisms involving phosphate-transfer reactions and in investigations of metabolic regulations dependent on pyruvate kinase alkaline phosphatase and phosphorylase phosphatase pathways
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Apexbio Technology LLC Eletriptan HBr 177834-92-3 10mM (in 1mL DMSO)
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Eletriptan hydrobromide (CAS 177834-92-3) is an orally bioavailable small molecule that acts as a selective agonist for the 5-hydroxytryptamine (serotonin) 5-HT1B and 5-HT1D receptors By activating these receptor subtypes eletriptan hydrobromide modulates cranial blood vessel tone and neuronal signaling implicated in migraine pathophysiology This compound is commonly utilized in preclinical and clinical research to investigate serotonergic modulation of neurovascular function and to explore therapeutic mechanisms relevant to migraine and related neurovascular disorders
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Medchemexpress LLC Bis-Tos-PEG7 | 69502-27-8 | C28H42O12S2 | 25 MG
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Bis-Tos-PEG7 is a PEG-based PROTAC linker utilized in the synthesis of PROTACs, which exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. It is characterized by the following features:
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC 1H-Indole, 2,3-bis(1H-indol-3-ylmethyl)- | 138250-72-3 | 375.47 | 100 MG
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2,3-Bis(3-indolylmethyl)indole significantly suppresses RANKL-induced osteoclast formation, actin ring formation, and bone resorption in a concentration-dependent manner. This product is for research use only.
- Significantly suppresses RANKL-induced osteoclast formation, actin ring formation, and bone resorption in a concentration-dependent manner.
- For research use only.
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Medchemexpress LLC κ-Carrageenan | 11114-20-8 | 25 G
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κ-Carrageenan is a natural polymer predominantly found in red seaweeds. It functions as an effective agent carrier for delivering curcumin into cancer cells to induce apoptosis. Additionally, κ-carrageenan can act as a potential inflammatory agent that exacerbates existing intestinal inflammation.
- Natural polymer predominantly available in red seaweeds.
- Effective agent carrier to deliver curcumin in cancer cells and to induce apoptosis.
- Serves as a potential inflammatory agent that magnifies existing intestinal inflammation.
- Used in animal modeling to create paw edema, colitis, and thrombosis models.
- Exhibits oral activity with rapid absorption, slow elimination, and prolonged retention in the body in mice.
- Accumulates in the liver and kidneys.
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Medchemexpress LLC Slingshot inhibitor D3 | 1715076-35-9 | 99.5% | 461.55 g·mol⁻¹ | C25H19NO4S2 | 10MM 1ML
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Slingshot inhibitor D3 is a potent, selective, reversible, and competitive inhibitor of Slingshot phosphatases (SSH family) used in biochemical and cell-based assays to probe SSH function. It is supplied as a ready-to-use 10 mM solution in DMSO and is intended for inhibition studies, mechanistic assays, and compound screening.
- Potent inhibition of Slingshot 1 (IC50 = 3 μM) and activity against Slingshot 2 (Ki = 3.9 μM).
- Supplied as a 10 mM solution in DMSO, 1 mL vial ready for use.
- High purity (~99.5%) suitable for research applications.
- Molecular weight 461.55 g·mol⁻¹ and formula C25H19NO4S2.
- Useful for biochemical and cell-based assays to study Slingshot-mediated dephosphorylation pathways.
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Medchemexpress LLC E3 ligase Ligand 63 | 2304754-51-4 | 99.8% | C13H12BrN3O3 | 10 G
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E3 ligase Ligand 63 is an E3 ligase ligand used for synthesizing CDK2 degrader 2. It functions as part of PROTACs, which are molecules designed to harness the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Utilized for synthesizing CDK2 degrader 2
- Part of PROTACs, which incorporate two distinct ligands
- Operates by harnessing the intracellular ubiquitin-proteasome system
- Achieves selective degradation of target proteins
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Apexbio Technology LLC Butenafine HCl 101827-46-7 10mM (in 1mL DMSO)
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Butenafine HCl (CAS 101827-46-7) is a small-molecule inhibitor targeting squalene epoxidase It is designed to inhibit this enzyme thereby disrupting fungal sterol biosynthesis Butenafine HCl exerts its biological activity primarily through inhibition of squalene epoxidase leading to impaired ergosterol synthesis and accumulation of squalene which disrupts fungal cell membrane integrity and results in cell death In biochemical studies Butenafine HCl demonstrates inhibitory activity with reported IC50 values ranging from approximately 0 03 M to 0 1 M depending on fungal species and experimental conditions Based on these pharmacological properties Butenafine HCl holds research potential in biomedical antifungal studies including investigations into fungal physiology antifungal efficacy and drug resistance mechanisms
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Medchemexpress LLC Bromo-peg3-azide | 1446282-43-4 | 98.2% | C8H16BrN3O3 | 50 MG
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Bromo-PEG3-azide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It also functions as a click chemistry reagent containing an azide group. PROTACs are utilized for the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- Can be used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups
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Medchemexpress LLC Daclatasvir dihydrochloride | 1009119-65-6 | MFCD25541736 | 99.7% | 811.80 g·mol⁻¹ | C40H52Cl2N8O6 | 25 MG
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Daclatasvir dihydrochloride is the dihydrochloride salt of daclatasvir, a potent HCV NS5A inhibitor supplied as a research-grade reference standard in a 25 mg sample. It is intended for in vitro screening, mechanistic studies of NS5A, and analytical reference work. Key identifiers include CAS 1009119-65-6, molecular formula C40H52Cl2N8O6, molecular weight 811.80 g·mol⁻1, and typical stated purity of 99.65%.
- High stated purity suitable for analytical reference.
- Provided as a 25 mg research sample.
- Identified by CAS 1009119-65-6 and molecular formula C40H52Cl2N8O6.
- Molecular weight 811.80 g·mol⁻1.
- Intended for in vitro and analytical applications.
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