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Filtered Search Results
Medchemexpress LLC INCB059872 dihydrochloride | 3062683-32-0 | 97.9% | C23H34N2O3 • 2HCl | 50 MG
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INCB059872 dihydrochloride is a potent, selective, and irreversible inhibitor of Lysine-Specific Demethylase 1 (LSD1). It exhibits potential antineoplastic activity and can be used in acute myeloid leukemia (AML) research. It has been shown to decrease proliferation in THP-1 acute monocytic and MV4-11 acute myeloid leukemia cells, and to increase the levels of CD11B in THP-1 cells when used at a concentration of 100 nM.
- Potent, selective, and irreversible LSD1 inhibitor
- Potential antineoplastic activity
- Useful in acute myeloid leukemia (AML) research
- Decreases proliferation in acute monocytic and myeloid leukemia cells
- Increases levels of CD11B in THP-1 cells
- Cited in Nature Medicine
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Medchemexpress LLC Bis-aminooxy-PEG2 | 98627-71-5 | MFCD00519242 | 95% | C6H16N2O4 | 100 MG
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Bis-aminooxy-PEG2 is a PEG-based PROTAC linker used in the synthesis of PROTACs.
- PROTACs contain two different ligands connected by a linker
- One ligand is for an E3 ubiquitin ligase
- The other ligand is for the target protein
- PROTACs exploit the intracellular ubiquitin-proteasome system
- Selectively degrade target proteins
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Medchemexpress LLC Volanesorsen sodium | 1573402-50-2 | 98.5% | C230H301N63Na19O125P19S19 | 1 MG
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Volanesorsen sodium is an antisense oligonucleotide inhibitor of apolipoprotein CIII (apo-CIII) mRNA. It works by reducing triglyceride levels and improving insulin resistance.
- Reduces triglyceride levels
- Improves insulin resistance
- Being investigated for the treatment of hypertriglyceridemia
- Being investigated for familial chylosiderosis syndrome
- Being investigated for type 2 diabetes
- Antisense oligonucleotide inhibitor of apolipoprotein CIII (apo-CIII) mRNA
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Medchemexpress LLC Monobenzone | 103-16-2 | 99.9% | 200.24 | 500 G
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Monobenzone is a potent skin depigmenting agent that induces depigmentation and shows good potential for vitiligo research. It is also a potent inhibitor of RNR enzyme activity by targeting the RRM2 protein, demonstrating significant anti-leukemia efficacy. It inhibits the proliferation and DNA synthesis of acute myeloid leukemia cells, and induces cell cycle arrest and apoptosis.
- Potent skin depigmenting agent
- Induces depigmentation
- Exhibits good potential for vitiligo research
- Potent inhibitor of RNR enzyme activity
- Targets RRM2 protein
- Significant anti-leukemia efficacy in vitro and in vivo
- Inhibits acute myeloid leukemia cells proliferation and DNA synthesis
- Induces cell cycle arrest and apoptosis
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Medchemexpress LLC Fluorenone | 486-25-9 | 99.98% | 180.20 | 500 G
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Fluorenone (9H-fluoren-9-one) is a biochemical reagent used as a biological material or organic compound for life science-related research. It is intended for research use only and can serve as an intermediate for organic synthesis.
- Biochemical reagent
- Organic compound for life science research
- Suitable for organic synthesis
- Solid appearance
- Light yellow to yellow color
- Soluble in DMSO
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Medchemexpress LLC Pilocarpine hydrochloride | 54-71-7 | 99.98% | 5 G
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Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist. It is intended for research use only.
- Potent M3-type muscarinic acetylcholine receptor agonist
- Unstable in solutions, freshly prepared is recommended
- Suitable for laboratory centrifugation and storage
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Medchemexpress LLC Cyclobenzaprine hydrochloride | 6202-23-9 | 100 MG
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Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist that acts centrally to provide skeletal muscle relaxation, alleviate muscle spasms, and reduce pain. It also possesses antiparasitic activity. Cyclobenzaprine hydrochloride shows promise for research in acute, painful skeletal muscle disorders and infectious diseases.
- Acts centrally to provide skeletal muscle relaxation
- Alleviates muscle spasms and reduces pain
- Possesses antiparasitic activity
- Shows promise for research in acute, painful skeletal muscle disorders
- Shows promise for research in infectious diseases
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Medchemexpress LLC Benserazide hydrochloride | 14919-77-8 | 99.7% | 10 MM 1 ML
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Benserazide hydrochloride (Serazide) is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. It also acts as a PKM2 inhibitor by directly binding to and blocking PKM2 enzyme activity, leading to inhibition of aerobic glycolysis and concurrent up-regulation of OXPHOS. This compound is suitable for research related to Parkinson's disease and melanoma.
- Acts as an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor.
- Inhibits PKM2 enzyme activity.
- Inhibits aerobic glycolysis and up-regulates OXPHOS.
- Supports research in Parkinson's disease and melanoma.
- Inhibits protein aggregation and minimizes amyloid-induced cytotoxicity in human neuroblastoma cell line SH-SY5Y.
- Increases exogenous L-DOPA-derived extracellular DA levels in 6-OHDA-lesioned male Wistar rats.
- Reduces central AADC activity in the striatum of rats with nigrostriatal denervation.
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Medchemexpress LLC Ethylparaben | 120-47-8 | 99.5% | 25 G
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Ethylparaben is the ethyl ester of paraben and is used as an antifungal preservative and food additive. It exhibits antibacteria and antifungal activities against various microbes.
- Used as an antifungal preservative
- Used as a food additive
- Shows antibacteria and antifungal activities
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Apexbio Technology LLC HyperChrom SP HP Agarose 100ml
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HyperChrom SP HP Agarose is a strong cation-exchange chromatography resin designed for bioseparation applications based on differences in molecular charge properties Employing a highly cross-linked agarose matrix this resin enables efficient separation of biological molecules such as recombinant proteins antibodies nucleic acids viruses virus-like particles and polysaccharides The chemically modified agarose backbone enhances rigidity allowing high flow rates under reduced backpressure facilitating streamlined scalable purification processes suitable for biomedical research and biopharmaceutical production
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Apexbio Technology LLC GM 6001 142880-36-2 5mg
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GM 6001 (Ilomastat Galardin CAS 142880-36-2) is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) including MMP-1 -2 -3 -8 and -9 with reported Ki values of 0 4 nM 0 5 nM 27 nM 0 1 nM and 0 2 nM respectively MMPs participate in extracellular matrix remodeling and mediate signaling events induced by GPCR agonists through EGFR transactivation GM 6001 suppresses EGFR phosphorylation ERK activation and subsequent DNA synthesis induced by stimuli such as bombesin and lysophosphatidic acid (LPA) Additionally this compound has potential applications in cartilage research facilitating meniscal repair under inflammatory conditions by dampening IL-1-mediated MMP activity
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000284222 BIS 2 3-DIBROMOPROPY 25MG
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Medchemexpress LLC Palbociclib hydrochloride | 571189-11-2 | 99.96% | C24H30ClN7O2 | 50 MG
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Palbociclib hydrochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. It exhibits potent anti-proliferative activity and induces cell cycle arrest in cancer cells, making it suitable for research in HR-positive and HER2-negative breast cancer and hepatocellular carcinoma.
- Orally active selective CDK4 and CDK6 inhibitor
- Exhibits potent anti-proliferative activity
- Induces cell cycle arrest in cancer cells
- Suitable for research in HR-positive and HER2-negative breast cancer
- Suitable for research in hepatocellular carcinoma
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Medchemexpress LLC Milnacipran hydrochloride | 101152-94-7 | 99.7% | 5 MG
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Milnacipran hydrochloride is an orally active serotonin and norepinephrine reuptake inhibitor. It specifically inhibits monoamine transporters with Ki values of 31 nM for the norepinephrine transporter and 8.5 nM for the serotonin transporter. This compound also inhibits pERK1/2 activation and exhibits antidepressant, anxiolytic, and analgesic properties. It is used in the study of major depressive disorder, anxiety disorders, and neuropathic pain, including fibromyalgia.
- Inhibits norepinephrine and serotonin transporters.
- Inhibits pERK1/2 activation.
- Possesses antidepressant, anxiolytic, and analgesic properties.
- Used in studies of major depressive disorder, anxiety disorders, and neuropathic pain.
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Medchemexpress LLC N-Isobutyrylguanosine | 64350-24-9 | 99.7% | 353.33 | 500 G
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iBu-rG (N-Isobutyrylguanosine) is a nucleoside compound that can be used to synthesize oligoribonucleotides. It is for research use only.
- Can be used to synthesize oligoribonucleotides.
- High purity (99.74%).
- Provided with data sheet, COA, SDS, and handling instructions.
- Available in both solid and pre-dissolved solution forms.
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