Tricarboxylic acids and derivatives

(1alpha,3alpha,5alpha)-1,3,5-Cyclohexanetricarboxylic Acid 98.0+%, TCI America™

CAS: 16526-68-4 Molecular Formula: C9H12O6 Molecular Weight (g/mol): 216.189 MDL Number: MFCD00075294 InChI Key: FTHDNRBKSLBLDA-UHFFFAOYSA-N PubChem CID: 349732 IUPAC Name: cyclohexane-1,3,5-tricarboxylic acid SMILES: C1C(CC(CC1C(=O)O)C(=O)O)C(=O)O

Medchemexpress LLC MRTX9768 | 2629314-68-5 | 99.48% | 424.43 | 50 MG

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MRTX9768 is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor. It inhibits SDMA and cell proliferation in HCT116 MTAP-del cells with marked selectivity over HCT116 MTAP-WT cells. This compound selectively targets MTAP/CDKN2A-deleted tumors, such as glioblastoma, and exhibits a favorable ADME profile.

• Potent and selective PRMT5-MTA complex inhibitor
• Inhibits SDMA and cell proliferation in MTAP-del cells
• Demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors
• Selectively targets MTAP/CDKN2A-deleted tumors, including glioblastoma
• Favorable ADME profile with high bioavailability and moderate to high clearance

Medchemexpress LLC Bragsin1 | 369631-68-5 | 99.9% | 273.16 | 10 MG

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Bragsin1 is a potent, selective, and noncompetitive inhibitor of the ArfGEF BRAG2, which inhibits Arf GTPase activation with an IC50 of 3 μM. It functions as a noncompetitive interfacial inhibitor by binding to the PH domain of BRAG2 and does not affect the Sec7 domain of human ArfGEFs. Bragsin1 also exhibits anti-cancer activity.

• Potent, selective, and noncompetitive inhibitor of ArfGEF BRAG2.
• Inhibits Arf GTPase activation with an IC50 of 3 μM.
• Binds to the PH domain of BRAG2.
• No effect on the Sec7 domain of human ArfGEFs.
• Exhibits anti-cancer activity.

Medchemexpress LLC Methyl 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate | 544450-68-2 | 99.9% | C16H16ClNO3S | 10MG

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COR659 (methyl 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate; CAS 544450-68-2) is a small-molecule positive allosteric modulator of the GABAB receptor used in preclinical neuroscience and addiction research. It has been reported to reduce alcohol- and chocolate-seeking behavior in rodent models and is supplied as a high-purity research chemical for in vitro and in vivo pharmacology studies.

• Potent GABAB positive allosteric modulator with demonstrated in vivo activity.
• High purity suitable for research applications.
• Well characterized chemical identifiers and molecular formula.
• Off-white solid form compatible with standard solvents such as DMSO.
• Storage and handling guidance provided for refrigerated and cryogenic conditions.

Medchemexpress LLC 3-Thiophenecarboxylic acid, 2-[(4-chlorobenzoyl)amino]-4-ethyl-5-methyl-, methyl ester | 544450-68-2 | 99.94% | 337.82 | 100 MG

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COR659 is a potent and effective GABAB positive allosteric modulator (PAM) that suppresses alcohol and chocolate self-administration in rats. Its effects are exerted through a composite mechanism, involving positive allosteric modulation of the GABAB receptor and an action at the cannabinoid CB1 receptor.

• Potent and effective GABAB positive allosteric modulator (PAM).
• Suppresses alcohol and chocolate self-administration in rats.
• Exerts effects through a composite mechanism.
• Involves positive allosteric modulation of the GABAB receptor.
• Acts at the cannabinoid CB1 receptor.
• Has shown cytotoxicity against mouse NIH/3T3 cells with an IC50 of 59 μM.
• Relevant to research in neurological, eye or ear disease, neurodegenerative disease, depression, Alzheimer's disease, and Parkinson's disease.

eMolecules​ Ambeed / (3aS3aS8aR8aR)-22-(13-diphenylpropane-22-diyl)bis(3a8a-dihydro-8H-indeno[12-d]oxazole) / 100mg / 600827831 / A1147876 / / 195703-68-5 / [null] / 510.637 / C35H30N2O2

Ambeed / (3aS3aS8aR8aR)-22-(13-diphenylpropane-22-diyl)bis(3a8a-dihydro-8H-indeno[12-d]oxazole) / 100mg / 600827831 / A1147876 / / 195703-68-5 / [null] / 510.637 / C35H30N2O2