Thiazoles
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Medchemexpress LLC Isobutyl-deoxynyboquinone | 1430798-22-3 | 99.7% | 326.35 | C18H18N2O4 | 5MG
Isobutyl-deoxynyboquinone (IB-DNQ) is a small-molecule quinone used as a selective substrate for NAD(P)H:quinone oxidoreductase 1 (NQO1) in preclinical research. It is employed to probe NQO1-dependent cytotoxicity and has demonstrated in vitro potency across cancer cell lines, with documented in vivo exposure in pharmacokinetic studies.
- Selective substrate for NQO1.
- Used to study NQO1-mediated cytotoxicity in cell-based assays.
- Demonstrates in vitro activity in SCCF cell lines.
- Molecular formula C18H18N2O4; molecular weight 326.35.
- Purity 99.7%.
- Appearance brown to red solid.
- Solubility DMSO 10 mg/mL; may require warming or sonication.
- Powder storage: -20°C (up to 3 years) or 4°C (up to 2 years); stock solutions: -80°C (6 months).
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Medchemexpress LLC Yl-5092 | 3056857-07-6 | 99.83% | 441.43 | 50 MG
YL-5092 is a selective YT521-B homology (YTH) domain-containing protein 1 (YTHDC1) inhibitor with an IC50 of 7.4 nM and a KD of 29.6 nM. It can suppress cancer cell proliferation and induce cell G0/G1 phase arrest and apoptosis. YL-5092 can be used for the research of cancer, such as acute myeloid leukemia (AML).
- Selective YTHDC1 inhibitor with IC50 of 7.4 nM and KD of 29.6 nM.
- Suppresses cancer cell proliferation.
- Induces cell G0/G1 phase arrest and apoptosis.
- Applicable for cancer research, including acute myeloid leukemia (AML).
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